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Literature summary for 6.4.1.2 extracted from

  • Kamata, M.; Yamashita, T.; Kina, A.; Funata, M.; Mizukami, A.; Sasaki, M.; Tani, A.; Funami, M.; Amano, N.; Fukatsu, K.
    Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors (2012), Bioorg. Med. Chem. Lett., 22, 3643-3647.
    View publication on PubMed
Search for more literature for 6.4.1.2

Inhibitors

Inhibitors Comment Organism Structure
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
-
 Homo sapiens
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
-
 Homo sapiens
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
-
 Homo sapiens
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
-
 Homo sapiens
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
-
 Homo sapiens
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
-
 Homo sapiens
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
-
 Homo sapiens
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
 Homo sapiens
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
-
 Homo sapiens
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
-
 Homo sapiens
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
-
 Homo sapiens
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
-
 Homo sapiens
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
-
 Homo sapiens
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00763
-
-
Homo sapiens Q13085
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
ACC1
-
 Homo sapiens
ACC2
-
 Homo sapiens
acetyl-CoA carboxylase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000044
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
0.0000085
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000009
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000013
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
0.000014
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000015
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000015
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000016
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000017
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000017
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000018
-
 pH and temperature not specified in the publication Homo sapiens 1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000022
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000023
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000027
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
0.000032
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000033
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000037
-
 pH and temperature not specified in the publication Homo sapiens 1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
0.00004
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000043
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000048
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
0.000049
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000051
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000063
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
0.000064
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000075
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000076
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000078
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000079
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00008
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000093
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.00011
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.00012
-
 pH and temperature not specified in the publication Homo sapiens 1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.00015
-
 pH and temperature not specified in the publication Homo sapiens 1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
0.00015
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
0.00015
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.00016
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.00016
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.00019
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00023
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00028
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00029
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.0003
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00035
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00035
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00036
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00041
-
 pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00051
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00065
-
 pH and temperature not specified in the publication Homo sapiens 1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea