Information on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase (NADPH)

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
1.1.1.34
-
RECOMMENDED NAME
GeneOntology No.
hydroxymethylglutaryl-CoA reductase (NADPH)
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
isoprene biosynthesis II (engineered)
-
Metabolic pathways
-
mevalonate pathway I
-
mevalonate pathway II (archaea)
-
Terpenoid backbone biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
(R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3-hydroxy-3-methyl-glutaryl CoA reductase
-
-
3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1
-
-
3-hydroxy-3-methylglutaryl co-enzyme A reductase
-
-
3-hydroxy-3-methylglutaryl CoA reductase
-
-
3-hydroxy-3-methylglutaryl CoA reductase
-
-
3-hydroxy-3-methylglutaryl CoA reductase
Q7YT62
-
3-hydroxy-3-methylglutaryl CoA reductase
-
-
3-hydroxy-3-methylglutaryl CoA reductase
-
-
3-hydroxy-3-methylglutaryl CoA reductase
-
-
3-hydroxy-3-methylglutaryl CoA reductase
-
-
3-hydroxy-3-methylglutaryl CoA reductase
-
-
3-hydroxy-3-methylglutaryl coenzyme A reductase
Q5RZ62
-
3-hydroxy-3-methylglutaryl coenzyme A reductase
-
-
3-hydroxy-3-methylglutaryl coenzyme A reductase
-
-
3-hydroxy-3-methylglutaryl coenzyme A reductase
Lactococcus lactis NZ9000
-
-
-
3-hydroxy-3-methylglutaryl coenzyme A reductase
-
-
3-hydroxy-3-methylglutaryl coenzyme A reductase 1
-
-
3-hydroxy-3-methylglutaryl-CoA reductase
-
-
-
-
3-hydroxy-3-methylglutaryl-CoA reductase
-
-
3-hydroxy-3-methylglutaryl-CoA reductase
-
-
3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)
-
-
-
-
3-hydroxy-3-methylglutaryl-coenzyme A reductase
B2KX91
-
3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
-
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Q1W675
-
3-hydroxymethylglutaryl coenzyme A reductase
-
-
acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
-
beta-hydroxy-beta-methylglutaryl coenzyme A reductase
-
-
-
-
beta-hydroxy-beta-methylglutaryl-Co A reductase
-
-
-
-
EuHMGR
Q5RZ62
-
HMG CoA reductase
-
-
HMG-CoA reductase
-
-
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
Aureobasidium pullulans MZKI B802
-
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
Debaryomyces hansenii CBS 767
-
-
-
HMG-CoA reductase
A0N0D3
-
HMG-CoA reductase
-
-
HMG-CoA reductase
Eurotium amstelodami MZKI A561
-
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
Hortaea werneckii MZKI B736
-
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
Phaeotheca triangularis MZKI B741
-
-
-
HMG-CoA reductase
Rattus norvegicus Sprague-Dawley
-
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
P12683
-
HMG-CoA reductase
Saccharomyces cerevisiae MZKI K86
-
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
Trimmatostroma salinum MZKI B734
-
-
-
HMG-CoA reductase
-
-
HMG-CoA reductase
Wallemia ichthyophaga EXF 994
-
-
-
HMG-CoAR
-
-
HMG-CoAR
-
-
HMG-CoAR
Rattus norvegicus Sprague-Dawley
-
-
-
HMG1
-
-
HMG2
-
-
HMG2.2
-
-
-
-
HMG3.3
-
-
-
-
HMGCoA reductase
-
-
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating CoA)
-
-
-
-
HMGCR
-
-
HMGR
-
-
-
-
HMGR
Aureobasidium pullulans MZKI B802
-
-
-
HMGR
Debaryomyces hansenii CBS 767
-
-
-
HMGR
Eurotium amstelodami MZKI A561
-
-
-
HMGR
B2KX91
-
HMGR
Q7YT62
-
HMGR
Hortaea werneckii MZKI B736
-
-
-
HMGR
Lactococcus lactis NZ9000
-
-
-
HMGR
-
-
HMGR
Mus musculus C57BL/6J
-
-
-
HMGR
Phaeotheca triangularis MZKI B741
-
-
-
HMGR
Saccharomyces cerevisiae MZKI K86
-
-
-
HMGR
Q1W675
-
HMGR
Trimmatostroma salinum MZKI B734
-
-
-
HMGR
Wallemia ichthyophaga EXF 994
-
-
-
HMGR1
-
-
-
-
HMGR1
Q7YT63
-
HMGR2
-
-
-
-
HMGR2
Q7YT63
-
hydroxy-3-methylglutoryl-Coenzyme A reductase
A0N0D3
-
hydroxymethylglutaryl CoA reductase (NADPH)
-
-
-
-
hydroxymethylglutaryl-coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
-
-
-
-
mevalonate:NADP+ oxidoreductase (acetylating CoA)
-
-
-
-
microsomal HMG-CoA reductase
-
-
NADPH-hydroxymethylglutaryl-CoA reductase
-
-
-
-
S-3-hydroxy-3-methylglutaryl-CoA reductase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9028-35-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
2 genes hmg1 and hmg2 encode 2 isozymes HMG1 and HMG2
-
-
Manually annotated by BRENDA team
ecotype Columbia
-
-
Manually annotated by BRENDA team
Aureobasidium pullulans MZKI B802
MZKI B802
-
-
Manually annotated by BRENDA team
cauliflower
-
-
Manually annotated by BRENDA team
Debaryomyces hansenii CBS 767
CBS 767
-
-
Manually annotated by BRENDA team
dual-function enzyme with acetoacetyl-coenzyme A thiolase and 3-hydroxy-3-methylglutaryl-coenzyme A reductase activities
-
-
Manually annotated by BRENDA team
Oliver
SwissProt
Manually annotated by BRENDA team
Eurotium amstelodami MZKI A561
MZKI A561
-
-
Manually annotated by BRENDA team
a triterpene-producing fungus, strain HG
SwissProt
Manually annotated by BRENDA team
; gene hmgR
-
-
Manually annotated by BRENDA team
lobster, 2 enzyme forms: a soluble and a membrane-bound enzyme
SwissProt
Manually annotated by BRENDA team
lobster, 2 enzyme forms: a soluble isozyme HMGR1 and a membrane-bound isozyme HMGR2
SwissProt
Manually annotated by BRENDA team
MZKI B736
-
-
Manually annotated by BRENDA team
salt-tolerant black yeast, strain MZKI B736, isozymes Hmg1 and Hmg2
-
-
Manually annotated by BRENDA team
Hortaea werneckii MZKI B736
MZKI B736
-
-
Manually annotated by BRENDA team
cv. Norin 1
-
-
Manually annotated by BRENDA team
collected from Panzhihua, Sichuan province, China, gene hmgr
-
-
Manually annotated by BRENDA team
Lactococcus lactis NZ9000
-
-
-
Manually annotated by BRENDA team
genes LcHMG1 and LcHMG2
-
-
Manually annotated by BRENDA team
Syrian hamster
-
-
Manually annotated by BRENDA team
C57BL/6J mice
-
-
Manually annotated by BRENDA team
Mus musculus C57BL/6J
C57BL/6J mice
-
-
Manually annotated by BRENDA team
Phaeotheca triangularis MZKI B741
MZKI B741
-
-
Manually annotated by BRENDA team
class II enzyme
-
-
Manually annotated by BRENDA team
male Charles River Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
Sprague-Dawley
-
-
Manually annotated by BRENDA team
young male Sprague-Dawley
Uniprot
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae MZKI K86
MZKI K86
-
-
Manually annotated by BRENDA team
cv. Irish Cobbler
-
-
Manually annotated by BRENDA team
cv. Rishiri, interspecific hybrid
-
-
Manually annotated by BRENDA team
; enzyme is not regulated by phosphorylation
-
-
Manually annotated by BRENDA team
Trimmatostroma salinum MZKI B734
MZKI B734
-
-
Manually annotated by BRENDA team
Schizotrypanum
-
-
Manually annotated by BRENDA team
Wallemia ichthyophaga EXF 994
EXF 994
-
-
Manually annotated by BRENDA team
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Crystallization/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
enzyme in complex with inhibitor lovastatin, from 1.2 M ammonium sulfate, at 20°C, a few days, larger crystals by microseeding, complexing with the inhibitor by soaking in a KOH solution, pH 9.0, containing 2 mM lovastatin, X-ray diffraction structure determination and analysis at 2.6 A resolution
-