Literature summary for 1.1.1.34 extracted from

Garcia-Pelayo, M.C.; Garcia-Peregrin, E.; Martinez-Cayuela, M.
Differential translational effects of myristic acid and eicosapentaenoic acid on 3-hydroxy-3-methylglutaryl-CoA reductase from Reuber H35 hepatoma cells (2004), Exp. Biol. Med., 229, 781-786.

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Activating Compound

Activating Compound	Comment	Organism	Structure
myristic acid	stimulates translation of the enzyme about 1.8fold at 0.15 mM, upregulation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
cycloheximide	downregulation of protein synthesis, synergistic with eicosapentanoic acid and myristic acid	Homo sapiens
eicosapentaenoic acid	inhibits translation of the enzyme about 50% at 0.15 mM, downregulation, slightly increases downregulation of protein synthesis by cycloheximide	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
52000	56000	proteolytically cleaved soluble enzyme fragment	Homo sapiens
96000	-	intact membrane protein	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+	Homo sapiens	-	(R)-mevalonate + CoA + 2 NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	proteolysis releases a soluble, active fragment of 52-56 kDa	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
Reuber H-35 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+	-	Homo sapiens	(R)-mevalonate + CoA + 2 NADP+	-	r

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Release 2023.1 (January 2023)