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Literature summary for 1.1.1.34 extracted from

  • Chen, X.; Wang, X.; Li, Z.; Kong, L.; Liu, G.; Fu, J.; Wang, A.
    Molecular cloning, tissue expression and protein structure prediction of the porcine 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) gene (2012), Gene, 495, 170-177.
    View publication on PubMed
Search for more literature for 1.1.1.34

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, sequence comparisons, RT-PCR and real-time PCR expression analysis Sus scrofa

Protein Variants

Protein Variants Comment Organism
L498I the naturally occuring mutation T1564C creates a c-Rel binding site Sus scrofa
M430T naturally occuring mutation T1392C Sus scrofa
additional information identification of five single nucleotide polymorphisms, three of them are synonymous mutations and the other two are missense mutations, the naturally occuring mutation T1541C causes a deletion of a CdxA element and a C/EBP binding site and created a c-Ets-binding site, and naturally occuring mutation G973T in exon 9, which is a synonymous mutation Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
97150
-
 x * 97150, sequence calculation Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Sus scrofa
-
 (R)-mevalonate + CoA + 2 NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa Q1W675
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein identification of five N-glycosylation sites Sus scrofa
lipoprotein identification of nineteen N-myristoylation sites and three characteristic sites Sus scrofa
phosphoprotein identification of a cAMP-and cGMP-dependent protein kinase phosphorylation site, thirteen Protein kinase C phosphorylation sites, and eleven Casein kinase II phosphorylation sites Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue subcutaneous, high expression level Sus scrofa
-
bladder high expression level Sus scrofa
-
cerebrum low expression level Sus scrofa
-
heart high expression level Sus scrofa
-
kidney high expression level Sus scrofa
-
large intestine medium expression level Sus scrofa
-
liver high expression level Sus scrofa
-
lung medium expression level Sus scrofa
-
ovary low expression level Sus scrofa
-
skeletal muscle longissimus, low expression level Sus scrofa
-
small intestine low expression level Sus scrofa
-
spinal cord low expression level Sus scrofa
-
spleen low expression level Sus scrofa
-
stomach low expression level Sus scrofa
-
uterus medium expression level Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Sus scrofa (R)-mevalonate + CoA + 2 NADP+
-
 ?

Subunits

Subunits Comment Organism
? x * 97150, sequence calculation Sus scrofa

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
 Sus scrofa
HMGR
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Sus scrofa

pI Value

Organism Comment pI Value Maximum pI Value
Sus scrofa sequence calculation
-
 6.14

General Information

General Information Comment Organism
additional information structure-function analysis, overview. Identification of three characteristic sites of hydroxymethylglutaryl-CoA reductase Sus scrofa
physiological function rate-limiting enzyme for cholesterol synthesis, regulated via a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate Sus scrofa