Inhibitors | Comment | Organism | Structure |
---|---|---|---|
F(4-fluoro)VAE | HMG-CoA competitive inhibitor | Rattus norvegicus | |
FVAE | HMG-CoA competitive inhibitor | Rattus norvegicus | |
GFPDGG | designed on the basis of the rigid peptide backbone, increases the inhibitory potency more than 300 times compared to the first isolated LPYP from soybean, overview | Rattus norvegicus | |
GFPEGG | HMG-CoA competitive inhibitor | Rattus norvegicus | |
GFPTGG | HMG-CoA competitive inhibitor; NADPH and HMG-CoA competitive inhibitor | Rattus norvegicus | |
GLPDGG | NADPH and HMG-CoA competitive inhibitor | Rattus norvegicus | |
GLPEGG | NADPH and HMG-CoA competitive inhibitor | Rattus norvegicus | |
GLPTGG | NADPH and HMG-CoA competitive inhibitor | Rattus norvegicus | |
IAVE | HMG-CoA competitive inhibitor | Rattus norvegicus | |
IAVP | NADPH competitive inhibitor | Rattus norvegicus | |
IAVPGEVA | isolated from soybean by pepsin | Rattus norvegicus | |
IVAE | HMG-CoA competitive inhibitor | Rattus norvegicus | |
LPYP | from soybean | Rattus norvegicus | |
YAVE | HMG-CoA competitive inhibitor | Rattus norvegicus | |
YVAE | HMG-CoA competitive inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hydroxymethylglutaryl-CoA + NADPH + H+ | Rattus norvegicus | - |
mevalonate + NADP+ + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hydroxymethylglutaryl-CoA + NADPH + H+ | - |
Rattus norvegicus | mevalonate + NADP+ + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HMG-CoA reductase | - |
Rattus norvegicus |
HMGR | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0015 | - |
- |
Rattus norvegicus | GFPDGG | |
0.0017 | - |
- |
Rattus norvegicus | GFPEGG | |
0.0038 | - |
- |
Rattus norvegicus | F(4-fluoro)VAE | |
0.0169 | - |
- |
Rattus norvegicus | GFPTGG | |
0.0194 | - |
- |
Rattus norvegicus | GLPTGG | |
0.0223 | - |
- |
Rattus norvegicus | GLPDGG | |
0.0272 | - |
- |
Rattus norvegicus | GLPEGG | |
0.0418 | - |
- |
Rattus norvegicus | YVAE | |
0.0438 | - |
- |
Rattus norvegicus | FVAE | |
0.0441 | - |
- |
Rattus norvegicus | IVAE | |
0.0526 | - |
- |
Rattus norvegicus | YAVE | |
0.0752 | - |
- |
Rattus norvegicus | IAVE | |
0.097 | - |
- |
Rattus norvegicus | IAVP | |
0.152 | - |
- |
Rattus norvegicus | IAVPGEVA | |
0.484 | - |
- |
Rattus norvegicus | LPYP |