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Literature summary for 1.1.1.34 extracted from
- Binding thermodynamics of statins to HMG-CoA reductase (2005), Biochemistry, 44, 11741-11748.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| atorvastatin | - |
Homo sapiens |  |
| cerivastatin | - |
Homo sapiens | |
| fluvastatin | - |
Homo sapiens | |
| pravastatin | - |
Homo sapiens | |
| rosuvastatin | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
NADPH | - |
Homo sapiens | |
| 0.07 | - |
3-hydroxy-3-methylglutaryl-CoA | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P04035 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Homo sapiens | mevalonate + CoA + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HMG-CoA reductase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000023 | - |
rosuvastatin | pH 6.8, 37°C | Homo sapiens | |
| 0.0000057 | - |
cerivastatin | pH 6.8, 37°C | Homo sapiens | |
| 0.000014 | - |
atorvastatin | pH 6.8, 37°C | Homo sapiens | |
| 0.000103 | - |
pravastatin | pH 6.8, 37°C | Homo sapiens | |
| 0.000256 | - |
fluvastatin | pH 6.8, 37°C | Homo sapiens | |
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