6.3.5.4: asparagine synthase (glutamine-hydrolysing)

This is an abbreviated version!
For detailed information about asparagine synthase (glutamine-hydrolysing), go to the full flat file.

Word Map on EC 6.3.5.4

6.3.5.4

leukemia

lymphoblastic

children

remission

vincristine

lymphoma

methotrexate

l-asparagine

prednisone

cyclophosphamide

marrow

erwinia

daunorubicin

doxorubicin

relapsed

cr

dexamethasone

consolidation

thrombosis

l-aspartic

chrysanthemi

etoposide

pegylated

reinduction

thromboembolism

cytarabine

antileukemic

glutaminase

intrathecal

prophylaxis

non-hodgkin

ifosfamide

event-free

arabinoside

antithrombin

carotovora

6-mercaptopurine

extranodal

philadelphia

agriculture

lymphosarcoma

smile

medicine

multiagent

myelosuppression

hypofibrinogenemia

standard-risk

pseudocysts

nutrition

teniposide

drug development

analysis

daunomycin

epipodophyllotoxins

idarubicin

Reaction

Synonyms

AS, AS-A, AS-B, AS1, ASN3, AsnA, ASNase, AsnB, ASNS, AsnS1, AsnS2, AsnS3, AsnS4, asparagine amidotransferase, Asparagine synthetase, Asparagine synthetase (glutamine hydrolyzing), Asparagine synthetase (glutamine), Asparagine synthetase (glutamine-hydrolysing), asparagine synthetase 1, asparagine synthetase 2, Asparagine synthetase A, Asparagine synthetase B, asparagine synthetase, glutamine-dependent, asparagine synthetase1, asparagine synthetase2, At5g10240, bacterial type asparagine synthetase A, CaAS1, glutamine-dependent amidotransferase, Glutamine-dependent asparagine synthetase, HvAS1 protein, HvAS2 protein, HvASN1, HvASN2, HvASN3, HvASN4, HvASN5, L-asparaginase, L-Asparagine synthetase, LDBPK_300470, LiAS-A, MLOC_37219, MLOC_44080, MLOC_63089, MLOC_72774, MLOC_75057, More, NAS2, Os03g0291500, Os06g0265000, OsAS1, OsAS2, PVAS1 protein, PVAS2, Ste10, Synthetase, Asn (glutamine), TaASN1, TaASN2, TaASN4, TaSN1, TaSN2, TS11 cell cycle control protein, type -II asparagine synthetase, type I asparagine synthetase, type II asparagine synthetase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

6.3.5.4 asparagine synthase (glutamine-hydrolysing)

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Results	in table
8	Activating Compound
20517	AA Sequence
12	Application
1	CAS Registry Number
60	Cloned(Commentary)
14	Cofactor
3	Crystallization (Commentary)
5649	Disease/ Diagnostics
7	Expression
46	General Information
7	General Stability
16	IC50 Value
176	Inhibitors
28	kcat/KM [mM/s]
28	Ki Value [mM]
165	KM Value [mM]
18	Localization
45	Metals/Ions
31	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
260	Organism
6	Pathway
6	PDB ID
23	pH Optimum
4	pH Range
1	pH Stability
6	pI Value
2	Posttranslational Modification
55	Protein Variants
34	Purification (Commentary)
12	Reaction
1	Reaction Type
148	Reference
3	Renatured (Commentary)
249	Source Tissue
11	Specific Activity [micromol/min/mg]
5	Storage Stability
206	Substrates and Products (Substrate)
32	Subunits
157	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
6	Temperature Stability [°C]
87	Turnover Number [1/s]

Organism

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Organism on EC 6.3.5.4 - asparagine synthase (glutamine-hydrolysing)

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Arabidopsis thaliana

2 entries

Arabidopsis thaliana Col-0

743980

Q9LFU1

UniProt

Asparagus officinalis

1720

Bacillus subtilis

three glutamine-dependent AsnB-type asparagine snythetase genes: asnB, asnH and asnO, formerly yisO

651646

Bacillus subtilis 168

three glutamine-dependent AsnB-type asparagine snythetase genes: asnB, asnH and asnO, formerly yisO

UniProt

Canis lupus familiaris

Hordeum vulgare subsp. vulgare

cv. Golden Promise

745465

F2CQ60, F2CWZ7, F2DDF6, Q93XP9

UniProt

Klebsiella aerogenes

the organism contains both enzymes EC 6.3.1.1. and EC 6.3.4.5. The gene asnA codes for NH4+-dependent Asn synthetases, EC 6.3.1.1, and the gene asnB codes for Gln-dependent Asn synthetase, EC 6.3.5.4

861

UniProt

Leishmania donovani BPK282A1

UniProt

UniProt

Leishmania infantum JPCM5

UniProt

1678, 1711, 1714

858

858, 1680, 1681, 1682, 1687, 1712, 1713

Oryctolagus cuniculus

1712

Oryza sativa

2 entries

Oryza sativa Japonica Group

cv. Nipponbare

UniProt

UniProt

v. Little Marvel, dark-grown

858, 1673, 1677, 1685, 1688, 1710, 1715, 1718, 1719

Saccharomyces cerevisiae

isoforms StAs1 and StAs2

UniProt

Vibrio cholerae serotype O1