6.3.5.4: asparagine synthase (glutamine-hydrolysing)

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For detailed information about asparagine synthase (glutamine-hydrolysing), go to the full flat file.

Word Map on EC 6.3.5.4

6.3.5.4

leukemia

lymphoblastic

children

remission

vincristine

lymphoma

methotrexate

l-asparagine

prednisone

cyclophosphamide

marrow

erwinia

daunorubicin

doxorubicin

relapsed

cr

dexamethasone

consolidation

thrombosis

l-aspartic

chrysanthemi

etoposide

pegylated

reinduction

thromboembolism

cytarabine

antileukemic

glutaminase

intrathecal

prophylaxis

non-hodgkin

ifosfamide

event-free

arabinoside

antithrombin

carotovora

6-mercaptopurine

extranodal

philadelphia

agriculture

lymphosarcoma

smile

medicine

multiagent

myelosuppression

hypofibrinogenemia

standard-risk

pseudocysts

nutrition

teniposide

drug development

analysis

daunomycin

epipodophyllotoxins

idarubicin

Reaction

Synonyms

AS, AS-A, AS-B, AS1, ASN3, AsnA, ASNase, AsnB, ASNS, AsnS1, AsnS2, AsnS3, AsnS4, asparagine amidotransferase, Asparagine synthetase, Asparagine synthetase (glutamine hydrolyzing), Asparagine synthetase (glutamine), Asparagine synthetase (glutamine-hydrolysing), asparagine synthetase 1, asparagine synthetase 2, Asparagine synthetase A, Asparagine synthetase B, asparagine synthetase, glutamine-dependent, asparagine synthetase1, asparagine synthetase2, At5g10240, bacterial type asparagine synthetase A, CaAS1, glutamine-dependent amidotransferase, Glutamine-dependent asparagine synthetase, HvAS1 protein, HvAS2 protein, HvASN1, HvASN2, HvASN3, HvASN4, HvASN5, L-asparaginase, L-Asparagine synthetase, LDBPK_300470, LiAS-A, MLOC_37219, MLOC_44080, MLOC_63089, MLOC_72774, MLOC_75057, More, NAS2, Os03g0291500, Os06g0265000, OsAS1, OsAS2, PVAS1 protein, PVAS2, Ste10, Synthetase, Asn (glutamine), TaASN1, TaASN2, TaASN4, TaSN1, TaSN2, TS11 cell cycle control protein, type -II asparagine synthetase, type I asparagine synthetase, type II asparagine synthetase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

6.3.5.4 asparagine synthase (glutamine-hydrolysing)

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Results	in table
8	Activating Compound
20517	AA Sequence
12	Application
1	CAS Registry Number
60	Cloned(Commentary)
14	Cofactor
3	Crystallization (Commentary)
5649	Disease/ Diagnostics
7	Expression
46	General Information
7	General Stability
16	IC50 Value
176	Inhibitors
28	kcat/KM [mM/s]
28	Ki Value [mM]
165	KM Value [mM]
18	Localization
45	Metals/Ions
31	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
260	Organism
6	Pathway
6	PDB ID
23	pH Optimum
4	pH Range
1	pH Stability
6	pI Value
2	Posttranslational Modification
55	Protein Variants
34	Purification (Commentary)
12	Reaction
1	Reaction Type
148	Reference
3	Renatured (Commentary)
249	Source Tissue
11	Specific Activity [micromol/min/mg]
5	Storage Stability
206	Substrates and Products (Substrate)
32	Subunits
157	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
6	Temperature Stability [°C]
87	Turnover Number [1/s]

KI Value

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KI Value on EC 6.3.5.4 - asparagine synthase (glutamine-hydrolysing)

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1.1 - 3.7

alpha,beta-methylene-ATP

4 entries

2.5

AMP

Lupinus albus

1709

0.91

AMP-PNP

Escherichia coli

649836

0.023

Asn

Vibrio cholerae serotype O1

Kis, versus Gln

661315

0.25

asparagine

Zea mays

B4FFJ0, B5U8J7, B5U8J8, B5U8J9

pH 7.6, 22°C

716573

beta-methylaspartate

Escherichia coli

649836

0.021 - 0.85

diphosphate

4 entries

150

Glu

Lupinus albus

1709

0.3

glutamate

Zea mays

B4FFJ0, B5U8J7, B5U8J8, B5U8J9

pH 7.6, 22°C

716573

0.25

L-asparagine

Zea mays

B4FFJ0, B5U8J7, B5U8J8, B5U8J9

pH 7.6, temperature not specified in the publication, recombinant nontagged soluble isozyme ZmAsn2

716573

1.1 - 7.2

L-cysteine sulfinic acid

5 entries

0.3

L-glutamate

Zea mays

B4FFJ0, B5U8J7, B5U8J8, B5U8J9

pH 7.6, temperature not specified in the publication, recombinant nontagged soluble isozyme ZmAsn2

716573

6.5 - 29

L-glutamic acid gamma-methyl ester

4 entries

6.6

L-glutamic acid gamma-methylester

Escherichia coli

649836

0.000285

sulfoximine adenylate

Homo sapiens

671350