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Literature summary for 6.3.5.4 extracted from

  • Boehlein, S.K.; Stewart, J.D.; Walworth, E.S.; Thirumoorthy, R.; Richards, N.G.J.; Schuster, S.M.
    Kinetic mechanism of Escherichia coli asparagine synthetase B (1998), Biochemistry, 37, 13230-13238.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
AMP-PNP competitive vs. ATP, noncompetitive vs. aspartate, uncompetitive vs. glutamine Escherichia coli
asparagine noncompetitive vs. ATP and aspartate Escherichia coli
beta-methylaspartate noncompetitive vs. ATP, competitive vs. aspartate, noncompetitive vs. glutamine Escherichia coli
diphosphate noncompetitive vs. ATP Escherichia coli
L-glutamic acid gamma-methylester uncompetitive vs. ATP, competitive vs. glutamine Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-aspartate + L-glutamine Escherichia coli
-
AMP + diphosphate + L-asparagine + L-glutamate
-
?
ATP + L-aspartate + NH3 Escherichia coli asparagine biosynthesis proceeds by initial reaction of aspartate and ATP to yield a beta-aspartyl-AMP intermediate, in the presence of glutamine, ammonia released in the N-terminal active site reacts with beta-aspartyl-AMP to yield asparagine and AMP AMP + diphosphate + L-asparagine
-
?
L-glutamine Escherichia coli
-
L-glutamate + NH3
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-aspartate + L-glutamine
-
Escherichia coli AMP + diphosphate + L-asparagine + L-glutamate
-
?
ATP + L-aspartate + NH3 asparagine biosynthesis proceeds by initial reaction of aspartate and ATP to yield a beta-aspartyl-AMP intermediate, in the presence of glutamine, ammonia released in the N-terminal active site reacts with beta-aspartyl-AMP to yield asparagine and AMP Escherichia coli AMP + diphosphate + L-asparagine
-
?
L-glutamine
-
Escherichia coli L-glutamate + NH3
-
?

Synonyms

Synonyms Comment Organism
AS-B
-
Escherichia coli
Asparagine synthetase B
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.91
-
AMP-PNP
-
Escherichia coli
6.6
-
L-glutamic acid gamma-methylester
-
Escherichia coli
18
-
beta-methylaspartate
-
Escherichia coli