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6.3.5.4: asparagine synthase (glutamine-hydrolysing)

This is an abbreviated version!
For detailed information about asparagine synthase (glutamine-hydrolysing), go to the full flat file.

Word Map on EC 6.3.5.4

Reaction

ATP
+
L-aspartate
+
L-glutamine
+
H2O
=
AMP
+
diphosphate
+
L-asparagine
+
L-glutamate

Synonyms

AS, AS-A, AS-B, AS1, ASN3, AsnA, ASNase, AsnB, ASNS, AsnS1, AsnS2, AsnS3, AsnS4, asparagine amidotransferase, Asparagine synthetase, Asparagine synthetase (glutamine hydrolyzing), Asparagine synthetase (glutamine), Asparagine synthetase (glutamine-hydrolysing), asparagine synthetase 1, asparagine synthetase 2, Asparagine synthetase A, Asparagine synthetase B, asparagine synthetase, glutamine-dependent, asparagine synthetase1, asparagine synthetase2, At5g10240, bacterial type asparagine synthetase A, CaAS1, glutamine-dependent amidotransferase, Glutamine-dependent asparagine synthetase, HvAS1 protein, HvAS2 protein, HvASN1, HvASN2, HvASN3, HvASN4, HvASN5, L-asparaginase, L-Asparagine synthetase, LDBPK_300470, LiAS-A, MLOC_37219, MLOC_44080, MLOC_63089, MLOC_72774, MLOC_75057, More, NAS2, Os03g0291500, Os06g0265000, OsAS1, OsAS2, PVAS1 protein, PVAS2, Ste10, Synthetase, Asn (glutamine), TaASN1, TaASN2, TaASN4, TaSN1, TaSN2, TS11 cell cycle control protein, type -II asparagine synthetase, type I asparagine synthetase, type II asparagine synthetase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
                6.3.5.4 asparagine synthase (glutamine-hydrolysing)

Expression

Expression on EC 6.3.5.4 - asparagine synthase (glutamine-hydrolysing)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
ASNS activity is highly responsive to cellular stress, primarily by increased transcription from the single gene located on chromosome 7. The transcription factor ATF4 binds to an enhancer element within the proximal promoter of the ASNS gene and activates transcription
gene PpAS1 expression is upregulated during drought, and in the dark in all organs. PpAS1 transcripts accumulate with seedlings that are grown under high concentrations of nitrate or ammonium. Ability of PtMYB1 to activate the transcription of PpAS1 in vivo, PtMYB1 negatively regulates PpAS1 promoter in pine protoplasts
human enzyme activity is highly regulated in response to cell stress, primarily by increased transcription from a single gene located on chromosome 7. Protein limitation or an imbalanced dietary amino acid composition activate the ASNS gene through the amino acid response, a process that is replicated in cell culture through limitation for any single essential amino acid. Endoplasmic reticulum stress also increases ASNS transcription through the PERK-eIF2-ATF4 arm of the unfolded protein response. Both the amino acid response and unfolded protein response lead to increased synthesis of ATF4, which binds to the C/EBP-ATF response element and induces ASNS transcription
-
infection with Xanthomonas campestris pv. vesicatoria induces early and strong CaAS1 expression in leaves. Significant induction of CaAS1 expression occurs in pepper leaves following treatment with salicylic acid, methyl jasmonate or wounding
-
infection with Xanthomonas campestris pv. vesicatoria induces early and strong CaAS1 expression in pepper leaves
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OsAS2 mRNA content decreases in roots when NH4+ is supplied
transcription factor ATF4 induces asparagine synthetase which results in glutamine-dependent asparagine synthesis from aspartate, in turn asparagine accumulation then suppresses GCN2 and reduces ATF4
-