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6.3.4.4: adenylosuccinate synthase

This is an abbreviated version!
For detailed information about adenylosuccinate synthase, go to the full flat file.

Word Map on EC 6.3.4.4

Reaction

GTP
+
IMP
 +
L-aspartate
=
GDP
 +
phosphate
 +
N6-(1,2-dicarboxyethyl)-AMP

Synonyms

adenosylsuccinate synthase, adenosylsuccinate synthetase, adenylo-succinate synthetase, Adenylosuccinate synthase, Adenylosuccinate synthetase, adenylosuccinate synthetase 1, AdSS, AdSS1, AdSS2, AdSSL1, AMPSase, AMPsS, Arabdss, AS-synthetase, ASS, IMP--aspartate ligase, IMP-aspartate ligase, mouse muscle synthetase, PfAdSS, purA, Succino-AMP synthetase, Succinoadenylic kinosynthetase, Wheatadss

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.4 adenylosuccinate synthase

Inhibitors

Inhibitors on EC 6.3.4.4 - adenylosuccinate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-Hydantocidin
-
-
(NH4)2SO4
-
25 mM
2,4-dihydro-4-(beta-D-ribofuranosyl)-1,2,4(3H)-triazol-3-one
2-mercaptosuccinate
-
-
3',5'-cyclic GMP
4-Oxo-2-aminopentanoic acid
-
i.e. 2-oxonorvaline, poor
5,5'-dithiobis(2-nitrobenzoate)
-
-
5-amino-4-(N-succinocarboxamide)imidazole ribonucleotide
-
-
5-amino-4-carbamoyl-imidazole ribonucleotide
-
-
6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate
-
-
6-mercaptopurine ribonucleotide
-
-
6-mercaptopurine riboside 5'-phosphate
-
-
6-Thio-GMP
6-thio-IMP
-
-
8-Aza-7-deaza-GMP
8-aza-GMP
8-Aza-IMP
-
-
acyclo-GMP
-
-
adenosine 3',5'-AMP
-
-
adenylosuccinate
allopurinol nucleotide
-
-
arabinosyl-GMP
argininosuccinate
aspartate analogs
-
-
beta,gamma-5'-Guanylylmethylene diphosphate
-
-
Ca2+
-
in presence of Mg2+
Carbamoylphosphate
-
-
Cd2+
-
in presence of Mg2+
CDP
-
-
CMP
-
-
cyanoalanine
-
poor
cyclic GMP
-
-
cysteine
-
poor
cysteine sulfonate
-
poor
D-fructose 1,6 bisphosphate
competitive with IMP and noncompetitive against GTP
D-fructose 1,6-bisphosphate
-
inhibits both isozymes competitively
dAMP
-
-
dCMP
-
-
dGDP
-
-
Formycin B monophosphate
-
-
fructose 1,6-diphosphate
fumarate
guanosine
-
-
guanosine 5'-(beta,gamma-imino)triphosphate
-
-
guanosine 5'-diphosphate
-
Guanosine 5'-diphosphate-3'-diphosphate
-
competitive with respect to GTP and noncompetitive with respect to L-Asp and IMP
Guanosine 5'-O-[S-(4-bromo-2,3-dioxobutyl)thio]phosphate
-
-
Hadacidin
Hg2+
-
reversed by addition of DTT
homocysteine
-
poor
Hydantocidin 5'-phosphate
hydroxylamine
-
-
Maleate
methionine sulfone
-
poor
Mn2+
-
in presence of Mg2+
N-(Thiocarboxy)-L-aspartic anhydride
-
5 mM, 27.5% inhibition
N-Acetyl-5'-phosphohydantocidin
N-Acetyl-N-hydroxyglycine
-
5 mM, 72.9% inhibition
N-acetylglycine
-
5 mM, 51.2% inhibition
N-benzoylglycine
-
5 mM, 6% inhibition
N-formyl-N-hydroxyglycine
i.e. hadacidin. competitive inhibitor of aspartate, showed uncompetitive inhibition with IMP and GTP
N-formylglycine
-
5 mM, 61.1% inhibition
N-Hydroxyaspartate
-
poor
N-hydroxyglycine
-
5 mM, 49.3% inhibition
N-methylaspartate
-
poor
nucleotides
-
acidic type L isozyme more strongly inhibited than basic type M isozyme
-
oligonucleotides
-
inhibition by single-stranded autonomously replicating sequences, highly specific inhibition by a 44-base DNA oligonucleotide carrying the autonomously replicating sequences core consensus sequence
oxaloacetate
-
-
Pb2+
-
in presence of Mg2+
Phenylglyoxal
-
GTP or IMP partially protect
phosphate
phosphoenolpyruvate
-
-
ppGpp
SCN-
-
i.e. thiocyanate
SO42-
succinate
TDP
-
-
TMP
-
-
UDP
-
-
UMP
-
-
Zn2+
-
in presence of Mg2+
additional information
-