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Literature summary for 6.3.4.4 extracted from

  • Honzatko, R.B.; Fromm, H.J.
    Structure-function studies of adenylosuccinate synthetase from Escherichia coli (1999), Arch. Biochem. Biophys., 370, 1-8.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Escherichia coli

Protein Variants

Protein Variants Comment Organism
H41N site-directed mutagenesis Escherichia coli
K16Q site-directed mutagenesis Escherichia coli
N38A site-directed mutagenesis Escherichia coli
R143L site-directed mutagenesis Escherichia coli
R303L site-directed mutagenesis Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Hadacidin
-
Escherichia coli
succinate poor inhibitor Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ active site Mg2+ Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + IMP + L-aspartate Escherichia coli
-
GDP + phosphate + adenylosuccinate
-
?
GTP + IMP + L-aspartate Escherichia coli first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from L-aspartate and IMP GDP + phosphate + adenylosuccinate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + IMP + L-aspartate
-
Escherichia coli GDP + phosphate + adenylosuccinate
-
?
GTP + IMP + L-aspartate first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from L-aspartate and IMP Escherichia coli GDP + phosphate + adenylosuccinate
-
?

Subunits

Subunits Comment Organism
dimer
-
Escherichia coli

Synonyms

Synonyms Comment Organism
adenosylsuccinate synthetase
-
Escherichia coli
Adenylosuccinate synthetase
-
Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7
-
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
Hadacidin
-
Escherichia coli
1
-
succinate
-
Escherichia coli