Information on EC 6.3.4.4 - Adenylosuccinate synthase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
6.3.4.4
-
RECOMMENDED NAME
GeneOntology No.
Adenylosuccinate synthase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
amination
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-
-
-
PATHWAY
KEGG Link
MetaCyc Link
adenosine ribonucleotides de novo biosynthesis
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Alanine, aspartate and glutamate metabolism
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Metabolic pathways
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Purine metabolism
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SYSTEMATIC NAME
IUBMB Comments
IMP:L-aspartate ligase (GDP-forming)
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SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
adenosylsuccinate synthase
-
-
adenosylsuccinate synthetase
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adenosylsuccinate synthetase
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adenosylsuccinate synthetase
-
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adenylo-succinate synthetase
-
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adenylo-succinate synthetase
Emericella nidulans pabaA1
-
-
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Adenylosuccinate synthase
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-
-
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Adenylosuccinate synthetase
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-
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
-
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Adenylosuccinate synthetase
-
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Adenylosuccinate synthetase
-
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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-
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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Adenylosuccinate synthetase
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adenylosuccinate synthetase 1
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AdSS
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-
-
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AdSS
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AdSS
Pyrococcus horikoshii OT-3
O58187
-
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AdSS1
-
; gene name
AdSS1
-
basic isozyme
AdSS1
A4Z6H0
-
AdSS2
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acidic isozyme
AdSS2
A4Z6H1
-
AdSSL1
Q8N142
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AMPSase
-
-
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AMPSase
-
-
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AS-synthetase
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ASS
Emericella nidulans pabaA1
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-
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IMP--aspartate ligase
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-
-
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IMP-aspartate ligase
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-
-
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mouse muscle synthetase
-
-
purA
Q59726
gene name
purA
Q59726
gene name
-
Succino-AMP synthetase
-
-
-
-
Succinoadenylic kinosynthetase
-
-
-
-
Wheatadss
-
-
CAS REGISTRY NUMBER
COMMENTARY
9023-57-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain pabaA1
-
-
Manually annotated by BRENDA team
Emericella nidulans pabaA1
strain pabaA1
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-
Manually annotated by BRENDA team
cloned into the temperature-inducible, high-copy-number plasmid vector, pMOB45. Upon temperature induction, cells containing this plasmid produce adenylosuccinate synthetase at approximately 40times the wild-type level
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-
Manually annotated by BRENDA team
strains BW25113 and MP101
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-
Manually annotated by BRENDA team
wild-type and mutant enzymes
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-
Manually annotated by BRENDA team
wild-type and mutant enzymes D13A, E14A, H41N, and K16Q
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-
Manually annotated by BRENDA team
wild-type and mutant enzymes D333N, D333E, and D333Q
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Manually annotated by BRENDA team
wild-type and mutant enzymes L228A, S240A, and Q224E
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Manually annotated by BRENDA team
wild-type and mutant enzymes R143L and D13A
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-
Manually annotated by BRENDA team
wild-type and mutant enzymes R303L, R304L, and R305L
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-
Manually annotated by BRENDA team
wild-type and mutant enzymes, R132K, R143L, and D231A
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-
Manually annotated by BRENDA team
wild-type and mutant enzymes: G15V, K331L, and K331R
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-
Manually annotated by BRENDA team
wild-type and mutant R143L
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-
Manually annotated by BRENDA team
wild-type and mutant R147L
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-
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
human
-
-
Manually annotated by BRENDA team
mouse
Uniprot
Manually annotated by BRENDA team
Pyrococcus horikoshii OT-3
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SwissProt
Manually annotated by BRENDA team
strain ST700
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-
Manually annotated by BRENDA team
strain ST700
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-
Manually annotated by BRENDA team
2 isozymic forms: acidic type L, and basic type M
-
-
Manually annotated by BRENDA team
maize
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-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
65
90
-
thermal unfolding of AdSS exhibits a melting temperature of 85°C with the process being only partially reversible, the half life of inactivation is 340 min, 150 min, 110 min, 60 min, 30 min and 15 min at 65, 70, 75, 80, 85 and 90°C, respectively
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
guanidine-HCl
-
dramatic loss in secondary structure above 4 M guanidine-HCl with complete loss in secondary structure at 5 M guanidine-HCl