6.3.4.4: adenylosuccinate synthase
This is an abbreviated version!
For detailed information about adenylosuccinate synthase, go to the full flat file.
Word Map on EC 6.3.4.4
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6.3.4.4
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purine
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gtp
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inosine
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hadacidin
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hypoxanthine
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formycin
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adenylosuccinase
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alanosine
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medicine
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saicar
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synthesis
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agriculture
- 6.3.4.4
- purine
- gtp
- inosine
- hadacidin
- hypoxanthine
- formycin
- adenylosuccinase
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alanosine
- medicine
-
saicar
- synthesis
- agriculture
Reaction
Synonyms
adenosylsuccinate synthase, adenosylsuccinate synthetase, adenylo-succinate synthetase, Adenylosuccinate synthase, Adenylosuccinate synthetase, adenylosuccinate synthetase 1, AdSS, AdSS1, AdSS2, AdSSL1, AMPSase, AMPsS, Arabdss, AS-synthetase, ASS, IMP--aspartate ligase, IMP-aspartate ligase, mouse muscle synthetase, PfAdSS, purA, Succino-AMP synthetase, Succinoadenylic kinosynthetase, Wheatadss
ECTree
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Application
Application on EC 6.3.4.4 - adenylosuccinate synthase
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medicine
synthesis
enzymes of the salvage pathway are good targets for anti-parasitic drugs
medicine
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most parasitic protozoa lack the de novo purine biosynthetic pathway and rely exclusively on the salvage pathway for their purine biosynthetic pathway, enzymes of the salvage pathway are candidate drug targets
medicine
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the adenylosuccinate synthase gene is not associated with susceptibility for schizophrenia
medicine
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genetic variation of inosine triphosphatase causing an accumulation of inosine triphosphate protects patients against ribavirin-induced anemia during treatment for chronic hepatitis C infection. ITP can be used for ATP biosynthesis via adenylosuccinate synthase in place of guanosine triphosphate. With ribavirin challenge, erythrocyte ATP reduction is more severe in the wild-type inosine triphosphatase ITPA genotype than in the hemolysis protective ITPA genotype. The alleviation of ATP reduction by the hemolysis protective ITPA genotype is canceled by the adenylosuccinate synthase inhibitor 6-mercaptoethanol
expression of mutant P242N in an inosine-producing strain results in an approximately 4.66fold increase in inosine production, to 0.41 g/L, in minimal medium without hypoxanthine accumulation
synthesis
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expression of mutant P242N in an inosine-producing strain results in an approximately 4.66fold increase in inosine production, to 0.41 g/L, in minimal medium without hypoxanthine accumulation
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