6.3.4.4: adenylosuccinate synthase
This is an abbreviated version!
For detailed information about adenylosuccinate synthase, go to the full flat file.
Word Map on EC 6.3.4.4
-
6.3.4.4
-
purine
-
gtp
-
inosine
-
hadacidin
-
hypoxanthine
-
formycin
-
adenylosuccinase
-
alanosine
-
medicine
-
saicar
-
synthesis
-
agriculture
- 6.3.4.4
- purine
- gtp
- inosine
- hadacidin
- hypoxanthine
- formycin
- adenylosuccinase
-
alanosine
- medicine
-
saicar
- synthesis
- agriculture
Reaction
Synonyms
adenosylsuccinate synthase, adenosylsuccinate synthetase, adenylo-succinate synthetase, Adenylosuccinate synthase, Adenylosuccinate synthetase, adenylosuccinate synthetase 1, AdSS, AdSS1, AdSS2, AdSSL1, AMPSase, AMPsS, Arabdss, AS-synthetase, ASS, IMP--aspartate ligase, IMP-aspartate ligase, mouse muscle synthetase, PfAdSS, purA, Succino-AMP synthetase, Succinoadenylic kinosynthetase, Wheatadss
ECTree
6.3.4.4 adenylosuccinate synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 6.3.4.4 - adenylosuccinate synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-dGTP + IMP + L-aspartate
2'-dGDP + phosphate + adenylosuccinate
-
-
-
?
ddGTP + IMP + L-aspartate
ddGDP + phosphate + adenylosuccinate
-
-
-
?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
GTP + IMP + Ala-3-nitronate
GDP + phosphate + N6-(L-1-carboxy-2-nitroethyl)AMP
-
-
-
?
ITP + IMP + L-aspartate
IDP + phosphate + adenylosuccinate
-
-
-
?
GTP + 2'-dIMP + L-Asp
GDP + phosphate + 2'-deoxysuccinoAMP
-
61% of the efficiency of IMP as substrate, V/Km
-
-
?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
-
-
-
-
?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
-
-
-
-
?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
-
i.e. allopurinol ribonucleotide
-
?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
-
-
-
-
?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
-
-
-
-
?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
-
-
-
?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
-
-
-
-
?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
-
8.8% of the efficiency of IMP as substrate , V/Km
-
-
?
GTP + beta-D-arabinosylIMP + L-Asp
GDP + phosphate + arabinosylsuccinoAMP
-
-
-
-
?
GTP + IMP + L-Asp
?
-
penultimate step in pathway of AMP biosynthesis
-
-
?
GTP + IMP + L-Asp
?
-
plays an important role in the interconversion of purines
-
-
?
GTP + IMP + L-Asp
?
-
plays an important role in the interconversion of purines
-
-
?
GTP + IMP + L-Asp
?
-
first committed step towards the de novo biosynthesis of AMP
-
-
?
GTP + IMP + L-Asp
?
-
first committed step towards the de novo biosynthesis of AMP
-
-
?
GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
catalyzing the first step in the de novo synthesis of adenylmonophosphate
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
catalyzes the first step in the conversion of IMP to AMP in de novo purine nucleotide metabolism
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
catalyzing the first committed step in de novo biosynthesis of AMP
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
catalyzing the first committed step in the biosynthesis of AMP
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from L-aspartate and IMP
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
governs the first committed step in de novo biosynthesis of AMP plays a significant role in de novo purine nucleotide biosynthesis, the purine nucleotide cycle, and/or salvage pathway for nucleotides
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
first committed step in AMP synthesis. Isoenzyme AdSS1 has a potential role in muscle metabolism
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
acidic and basic isozymes, which participates in the first committed step of de novo AMP biosynthesis and/or the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
catalyzes the first committed step in the de novo biosynthesis of AMP
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
governs the committed step of AMP biosynthesis
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
salvage pathway
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
salvage pathway, catalyzing the first committed step in the synthesis of AMP from IMP
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
function in adenine nucleotide biosynthesis
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
key enzyme for the synthesis of adenosine de novo, first committed step in synythesis of adenosine, located at the branchpoint of AMP and GMP synthesis
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
catalyzing the first step in the de novo sythesis of adenylmonophosphate
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + adenylosuccinate
-
first committed step in the de novo biosynthesis of adenosine monophosphate and component of the purine nucleotide cycle
-
?
GTP + IMP + L-aspartate
GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
i.e. adenylosuccinate
-
?
GTP + IMP + L-aspartate
GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
i.e. adenylosuccinate
-
?
GTP + IMP + L-aspartate
GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
-
-
?
GTP + IMP + L-aspartate
GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
function in adenine nucleotide biosynthesis
-
?
ITP + IMP + L-Asp
IDP + phosphate + adenylosuccinate
-
-
ITP can be used for ATP biosynthesis via adenylosuccinate synthase in place of guanosine triphosphate
-
?
additional information
?
-
-
vertebrates possess two isozymes, the acidic is similar to the synthetase from bacteria and plants, the basic isozyme participates in the purine nucleotide cycle
-
?
additional information
?
-
-
ATP cannot be used as substrate instead of GTP
-
?
