6.3.4.21: nicotinate phosphoribosyltransferase
This is an abbreviated version!
For detailed information about nicotinate phosphoribosyltransferase, go to the full flat file.
Word Map on EC 6.3.4.21
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6.3.4.21
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salvage
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nampt
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2.4.2.11
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quinolinate
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nicotinamidase
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deamidase
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preiss-handler
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nmnat
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medicine
- 6.3.4.21
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salvage
- nampt
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2.4.2.11
- quinolinate
- nicotinamidase
- deamidase
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preiss-handler
- nmnat
- medicine
Reaction
Synonyms
EC 2.4.2.11, LOC_Os03g62110, More, NA phosphoribosyltransferase, NAPRT, NaPRT1, NAPRTase, niacin ribonucleotidase, nicotinate phosphoribosyltransferase, nicotinate phosphoribosyltransferases, nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase, nicotinic acid mononucleotide glycohydrolase, nicotinic acid mononucleotide pyrophosphorylase, nicotinic acid phosphoribosyltransferase, NPRTase, pncB
ECTree
6.3.4.21 nicotinate phosphoribosyltransferaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 6.3.4.21 - nicotinate phosphoribosyltransferase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
acetyl-CoA
at 1 mM 40% inhibition of activity (concentrations of substrates 1 mM)
CoA
at 1 mM 70% inhibition of activity (concentrations of substrates 1 mM)
D-fructose 1,6-bisphosphate
at 1 mM 36% inhibition of activity (concentrations of substrates 1 mM)
glutaryl-CoA
at 1 mM 42% inhibition of activity (concentrations of substrates 1 mM)
glyceraldehyde 3-phosphate
at 1 mM 27% inhibition of activity (concentrations of substrates 1 mM)
phosphoenolpyruvate
at 1 mM 33% inhibition of activity (concentrations of substrates 1 mM)
succinyl-CoA
at 1 mM 53% inhibition of activity (concentrations of substrates 1 mM)
5-phospho-alpha-D-ribose 1-diphosphate
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at high concentrations, when Mg2+ below 0.03 mM
ATP
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3 mM, competitive inhibition of nicotinic acid mononucleotide formation in mutants enzymes
nicotinate mononucleotide
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competitive to MgATP2-; non-competitive to nicotinate
nicotinate mononucleotide
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competitive to nicotinate and noncompetitive to phosphoribobose diphosphate
additional information
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no inhibition by nicotinamide; no inhibition by quinolinic acid, AMP, GMP
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additional information
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no inhibition by nicotinamide; no inhibition by nicotinate, up to 10 mM
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additional information
not inhibited by up to 1 mM NAD+, lack of feedback inhibition by NAD+
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additional information
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not inhibited by up to 1 mM NAD+, lack of feedback inhibition by NAD+
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additional information
not inhibitory: FK866. NaPRTase acks a tunnel that, in nicotinamide phosphoribosiltransferase EC 2.4.2.12, represents the binding site of inhibitor FK866
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additional information
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not inhibitory: FK866. NaPRTase acks a tunnel that, in nicotinamide phosphoribosiltransferase EC 2.4.2.12, represents the binding site of inhibitor FK866
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additional information
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no inhibition by antibodies against pig kidney quinolinate phosphoribosyltransferase; no inhibition by nicotinamide mononucleotide, deamino-NAD+
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