6.3.4.21: nicotinate phosphoribosyltransferase

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For detailed information about nicotinate phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

EC 2.4.2.11, LOC_Os03g62110, More, NA phosphoribosyltransferase, NAPRT, NaPRT1, NAPRTase, niacin ribonucleotidase, nicotinate phosphoribosyltransferase, nicotinate phosphoribosyltransferases, nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase, nicotinic acid mononucleotide glycohydrolase, nicotinic acid mononucleotide pyrophosphorylase, nicotinic acid phosphoribosyltransferase, NPRTase, pncB

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.21 nicotinate phosphoribosyltransferase

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11	Activating Compound
35699	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
46	Cofactor
3	Crystallization (Commentary)
88	Disease/ Diagnostics
1	Expression
1	General Information
9	General Stability
1	IC50 Value
60	Inhibitors
4	kcat/KM [mM/s]
41	KM Value [mM]
5	Localization
31	Metals/Ions
22	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
49	Organism
7	Pathway
2	PDB ID
8	pH Optimum
5	pH Range
3	pH Stability
13	Protein Variants
17	Purification (Commentary)
5	Reaction
5	Reaction Type
42	Reference
54	Source Tissue
24	Specific Activity [micromol/min/mg]
8	Storage Stability
62	Substrates and Products (Substrate)
11	Subunits
57	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
3	Temperature Stability [°C]
5	Turnover Number [1/s]

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Application on EC 6.3.4.21 - nicotinate phosphoribosyltransferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

Q6XQN6

NAPRT is amplified and overexpressed in a subset of common types of cancer, including ovarian cancer, where NAPRT expression correlates with a BRCAness gene expression signature. Both NAPRT and nicotinamide phosphoribosyltransferase NAMPT increase intracellular NAD+ levels. NAPRT silencing reduces energy status, protein synthesis, and cell size in ovarian and pancreatic cancer cells. NAPRT silencing sensitizes cells to NAMPT inhibitors both in vitro and in vivo. Reducing NAPRT levels in a BRCA2-deficient cancer cell line exacerbates DNA damage in response to chemotherapeutics

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