6.3.4.21: nicotinate phosphoribosyltransferase
This is an abbreviated version!
For detailed information about nicotinate phosphoribosyltransferase, go to the full flat file.
Word Map on EC 6.3.4.21
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6.3.4.21
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salvage
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nampt
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2.4.2.11
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quinolinate
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nicotinamidase
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deamidase
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preiss-handler
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nmnat
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medicine
- 6.3.4.21
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salvage
- nampt
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2.4.2.11
- quinolinate
- nicotinamidase
- deamidase
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preiss-handler
- nmnat
- medicine
Reaction
Synonyms
EC 2.4.2.11, LOC_Os03g62110, More, NA phosphoribosyltransferase, NAPRT, NaPRT1, NAPRTase, niacin ribonucleotidase, nicotinate phosphoribosyltransferase, nicotinate phosphoribosyltransferases, nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase, nicotinic acid mononucleotide glycohydrolase, nicotinic acid mononucleotide pyrophosphorylase, nicotinic acid phosphoribosyltransferase, NPRTase, pncB
ECTree
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Source Tissue
Source Tissue on EC 6.3.4.21 - nicotinate phosphoribosyltransferase
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very low protein expression level (mouse polyclonal anti-human NAPRT antibody) and enzymatic activity (TLC)
additional information
1.9 kb mRNA detected by Northern blot analysis, moderate expression
exogenously added nicotinic acid (1-10 microM) leads to increase in basal total NAD++ level (revealed by ESI-MS) in a dose-dependent manner and to NaAD+ accumulation which are reduced by siRNA-based knock-down of endogenous NAPRT, knock-down does not affect basal NAD++ levels (503 +/-104 microM) in absence of exogenous nicotinic acid, exogenously added nicotinic acid decreases oxidative cytotoxicity (by 30-50 microM hydrogen peroxide) through elevated NAD+ levels mediated by NAPRT activity as revealed by siRNA-based knock-down of NAPRT
detected by Western blot using mouse polyclonal anti-human NAPRT antibody, robust endogenous activity
detected by Western blot using mouse polyclonal anti-human NAPRT antibody, robust endogenous activity
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gene is ubiquitously expressed at the mRNA level in all normal human tissues tested. No expression MKN-28 cell
additional information
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distribution in rat tissues: trace activities in brain, lung or stomach, not in thigh muscle, testis or serum