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6.3.4.21: nicotinate phosphoribosyltransferase

This is an abbreviated version!
For detailed information about nicotinate phosphoribosyltransferase, go to the full flat file.

Word Map on EC 6.3.4.21

Reaction

nicotinate
+
5-phospho-alpha-D-ribose 1-diphosphate
 +
ATP
 +
H2O
=
beta-nicotinate D-ribonucleotide
 +
diphosphate
 +
ADP
 +
phosphate

Synonyms

EC 2.4.2.11, LOC_Os03g62110, More, NA phosphoribosyltransferase, NAPRT, NaPRT1, NAPRTase, niacin ribonucleotidase, nicotinate phosphoribosyltransferase, nicotinate phosphoribosyltransferases, nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase, nicotinic acid mononucleotide glycohydrolase, nicotinic acid mononucleotide pyrophosphorylase, nicotinic acid phosphoribosyltransferase, NPRTase, pncB

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.21 nicotinate phosphoribosyltransferase

Engineering

Engineering on EC 6.3.4.21 - nicotinate phosphoribosyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D19A
activity completely abolished
D288A
about 10% of wild type activity
G169A
about 40% of wild type activity
G209A
about 20% of wild type activity
G379A
activity completely abolished
H213A
N357A
about 80% of wild type activity
R318A
activity strictly dependent on the presence of ATP
S381A
about 40% of wild type activity
T380A
about 50% of wild type activity
Y21A
activity strictly dependent on the presence of ATP
P21L
mutation identified in a strain with early leaf sensescence, mutation causes the expression of the gene at the transcriptional level to decline by 40% in fully expanded leaves. Leaf nicotinate and nicotinamide contents are elevated, while NAD levels are reduced. Leaf tissue of P21L exhibits significant DNA fragmentation and H2O2 accumulation, along with up-regulation of genes associated with senescence. The mutant also shows reduced expression of SIR2-like genes SRT1 and SRT2 and increased acetylation of histone H3K9