6.3.1.2: glutamine synthetase

This is an abbreviated version!
For detailed information about glutamine synthetase, go to the full flat file.

Reaction

Synonyms

AmGLN1, ATP glutamate-ammonia ligase, Chloroplast GS2, Clone lambda-GS28, Clone lambda-GS31, Clone lambda-GS8, Cytoplasmic GS3, Cytosolic GS1, gamma-glutamyl transferase, gamma-glutamyl:ammonia ligase, gamma-glutamylhydroxamate synthetase, Gln isozyme alpha, Gln isozyme beta, Gln isozyme gamma, Gln synthetase, GLN1,1, GLN1,2, GLN1,3, GLN1,4, GLN1-1, GLN1-2, Gln1;1, Gln1;2, Gln1;3, Gln1;4, Gln1;5, GLN2, GlnA, glnA-1, GlnA1, GlnA2, GlnA3, GlnA4, GlnN, GlnR, GluA, GLUL, Glutamate--ammonia ligase, glutamate-ammonia ligase, Glutamine synthetase, glutamine synthetase cytosolic isozyme 1, glutamine synthetase cytosolic isozyme 2, glutamine synthetase I, glutamine synthetase type II, glutamine synthetase type III, Glutamylhydroxamic synthetase, GS, GS type I, GS type-1, GS(1), GS-II, GS1, GS1 kinase, GS1-1, GS1-2, GS107, GS112, GS117, GS12, GS122, GS1a, GS1beta1, GS1gamma1, GS2, GS2a, GS3, GSI, GSII, GSIII, Isozyme delta, L-glutamate:ammonia ligase, L-glutamate:ammonia ligase (ADP-forming), L-Glutamine synthetase, LDBPK_060370, LdGS, MM_0964, MtGS, N47/N48, OsGLN1,1, OsGLN1,2, protein transacetylase, S2205/S2287, SSO0366, Synthetase, glutamine, TAase, type I glutamine synthetase, type III glutamine synthetase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

                6.3.1.2 glutamine synthetase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
66	Activating Compound
47140	AA Sequence
38	Application
1	CAS Registry Number
101	Cloned(Commentary)
98	Cofactor
15	Crystallization (Commentary)
4106	Disease/ Diagnostics
25	Expression
67	General Information
22	General Stability
139	IC50 Value
641	Inhibitors
20	kcat/KM [mM/s]
126	Ki Value [mM]
321	KM Value [mM]
103	Localization
242	Metals/Ions
162	Molecular Weight [Da]
181	Natural Substrates/ Products (Substrates)
770	Organism
8	Oxidation Stability
14	Pathway
630	PDB ID
102	pH Optimum
16	pH Range
9	pH Stability
23	pI Value
22	Posttranslational Modification
94	Protein Variants
100	Purification (Commentary)
30	Reaction
1	Reaction Type
387	Reference
3	Renatured (Commentary)
375	Source Tissue
60	Specific Activity [micromol/min/mg]
15	Storage Stability
566	Substrates and Products (Substrate)
161	Subunits
272	Synonyms
1	Systematic Name
48	Temperature Optimum [°C]
9	Temperature Range [°C]
45	Temperature Stability [°C]
46	Turnover Number [1/s]

Posttranslational Modification

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Posttranslational Modification on EC 6.3.1.2 - glutamine synthetase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Posttranslational Modification Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

adenylylation

7 entries

nitrosylation

Medicago truncatula

O04998, O04999

isozyme MtGS2a activity is inhibited by thiol residue nitrosylation

728509

phosphoprotein

5 entries

proteolytic modification

3 entries

side-chain modification

Medicago truncatula

O04998, O04999

the enzyme is regulated by tyrosine nitration. The enzyme is nitrated in planta and its nitration status changes in relation to active nitrogen fixation

728509

ubiquitinylation

4 entries

additional information

Corynebacterium glutamicum

-

GlnA1 is subject to posttranslational modification, while GlnA2 is not

692709

adenylylation

Mycobacterium tuberculosis

P9WN39

regulation via adenylation, the enzyme is substrate for Escherichia coli adenylyl transferase, but only low adenylylation states are accessible

662218

adenylylation

Mycobacterium tuberculosis H37Rv

-

regulation via adenylation, the enzyme is substrate for Escherichia coli adenylyl transferase, but only low adenylylation states are accessible

-

adenylylation

Mycobacterium tuberculosis variant bovis

-

regulation via adenylation, the enzyme is substrate for Escherichia coli adenylyl transferase, adenylylation state of Mycobacterium bovis enzyme is higher than with the enzyme of pathogenic Mycobacterium tuberculosis

662218

adenylylation

Pseudomonas aeruginosa

-

enzyme activity is regulated by adenylylation-deadenylylation

661971

adenylylation

Pseudomonas aeruginosa

-

the enzyme is regulated by adenylylation/deadenylylation. High levels of deadenyllylated biosynthetically active glutamine synthetase are observed in cultures growing with limiting amounts of nitrogen while synthesis of the enzyme is repressed and that present is adenylylated in cultures with excess nitrogen

391443

adenylylation

Pseudomonas fluorescens

-

enzyme activity is regulated by adenylylation-deadenylylation

661971

adenylylation

Pseudomonas putida

-

enzyme activity is regulated by adenylylation-deadenylylation

661971

phosphoprotein

Bos taurus

-

-

676918

phosphoprotein

Homo sapiens

-

-

676918

phosphoprotein

Medicago truncatula

-

phosphorylation in root nodules

675138

phosphoprotein

Mus musculus

-

-

676918

phosphoprotein

Rattus norvegicus

-

-

676918

proteolytic modification

Gallus gallus

-

the N-terminus of glutamine synthetase, which constitutes a weak mitochondrial targeting signal, is sufficient to direct a chimeric protein to the mitochondria in hepatocytes and to the cytoplasm in astrocytes

715711

proteolytic modification

Medicago truncatula

Q84UC1

deduced protein contains a target peptide and is predicted to be driven to the plastid

714625

proteolytic modification

Medicago truncatula

O04998

the first 49 amino acids of the N-terminus are predicted to be the transit peptide, the sorting signal for targeting nucleus-encoded proteins to the plastids, which is cleaved during the import. The protein can only assemble to its active form when this sorting signal is removed

746127

ubiquitinylation

Bos taurus

-

-

676918

ubiquitinylation

Homo sapiens

-

-

676918

ubiquitinylation

Mus musculus

-

-

676918

ubiquitinylation

Rattus norvegicus

-

-

676918