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Disease on EC 6.3.1.2 - glutamine synthetase

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DISEASE
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Acidosis
Acid-base regulation of hepatic glutamine metabolism and ureagenesis: study with 15N.
Effect of collecting duct-specific deletion of both Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) on renal response to metabolic acidosis.
Glutamine is a potentially limiting amino acid for milk production in dairy cows: a hypothesis.
Glutamine synthetase activity of muscle in acidosis.
Glutamine synthetase and plasma glutamine in augmented ammoniagenesis in acidosis.
Glutamine-synthesizing activity in lungs of fed, starved, acidotic, diabetic, injured and septic rats.
Hyperchloremic metabolic acidosis due to deferasirox in a patient with beta thalassemia major.
Inhibition of glutamine synthetase in the mouse kidney: a novel mechanism of adaptation to metabolic acidosis.
Metabolic acidosis in sheep alters expression of renal and skeletal muscle amino acid enzymes and transporters.
Plasma amino acid concentrations and mRNA expression of components related to protein degradation in lambs with nutritionally induced metabolic acidosis.
Proximal tubule-specific glutamine synthetase deletion alters basal and acidosis-stimulated ammonia metabolism.
Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver.
Renal ammoniagenesis and acid excretion in the dogfish, Squalus acanthias.
Renal recovery from metabolic acidosis in the rat: no role for glutamine synthetase.
The kidney of chicken adapts to chronic metabolic acidosis: in vivo and in vitro studies.
Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa.
Acidosis, Lactic
Tubulointerstitial nephropathy persisting 20 months after discontinuation of chronic intake of germanium lactate citrate.
Acromegaly
Bone isoenzyme of serum alkaline phosphatase in acromegaly.
Acute Coronary Syndrome
Increased gamma-glutamyl transferase level is associated with absence of coronary collateral vessels in patients with acute coronary syndrome: an observational study.
Relation of Gamma-Glutamyl Transferase to Cardiovascular Events in Patients With Acute Coronary Syndromes.
Serum gamma-glutamyl transferase activity: new high-risk criteria in acute coronary syndrome patients?
The value of gamma glutamyltransferase in predicting myocardial infarction in patients with acute coronary syndrome.
Acute Kidney Injury
Clinical utility of urine kidney injury molecule-1 (KIM-1) and gamma-glutamyl transferase (GGT) in the diagnosis of canine acute kidney injury.
Specimen collection time for enzyme analysis in urine.
Validation of a spectrophotometric method for GGT measurement in canine urine and determination of the urine GGT-to-creatinine ratio reference interval and biological variation in 41 healthy dogs.
Acute-On-Chronic Liver Failure
Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity.
Prognostic factors of the short-term outcomes of patients with hepatitis B virus-associated acute-on-chronic liver failure.
Adenoma
A Limited Immunohistochemical Panel Can Subtype Hepatocellular Adenomas for Routine Practice.
Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers.
Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum.
Hepatocellular adenomas in a large community population, 2000 to 2010: reclassification per current World Health Organization classification and results of long-term follow-up.
Hepatocellular carcinoma arising in a pigmented telangiectatic adenoma with nuclear ?-catenin and glutamine synthetase positivity: case report and review of the literature.
Relationship between serum gamma-glutamyl transferase level and colorectal adenoma.
Adenoma, Liver Cell
Atypical hepatocellular adenoma-like neoplasms with ?-catenin activation show cytogenetic alterations similar to well-differentiated hepatocellular carcinomas.
Beta-catenin-activated hepatocellular adenoma in a male.
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
Correlation of exon 3 ?-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma.
Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques.
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma.
Diffuse glutamine synthetase overexpression restricted to areas of peliosis in a ?-catenin-activated hepatocellular adenoma: a potential pitfall in glutamine synthetase interpretation.
Glutamine synthetase interpretation in hepatocellular adenoma.
Glutamine synthetase staining and CTTNB1 mutation in hepatocellular adenomas.
Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis.
Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight/obesity, and inflammatory subtype.
Hepatocellular carcinoma arising in a pigmented telangiectatic adenoma with nuclear ?-catenin and glutamine synthetase positivity: case report and review of the literature.
Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor.
Hepatocellular tumors: immunohistochemical analyses for classification and prognostication.
Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers: a tricky aspect of a conditional knockout mouse model.
Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology.
Predictive Patterns of Glutamine Synthetase Immunohistochemical Staining in CTNNB1-mutated Hepatocellular Adenomas.
Unclassified hepatocellular adenoma expressing ASS1 associated with inflammatory hepatocellular adenomas.
Update on the pathology of liver neoplasms.
Utility of an Immunohistochemical Panel Consisting of Glypican-3, Heat-shock Protein-70, and Glutamine Synthetase in the Distinction of Low-grade Hepatocellular Carcinoma From Hepatocellular Adenoma.
Value and limits of routine histology alone or combined with glutamine synthetase immunostaining in the diagnosis of hepatocellular adenoma subtypes on surgical specimens.
Adrenal Insufficiency
A multicenter, phase 2 study to evaluate the efficacy and safety of osilodrostat, a new 11?-hydroxylase inhibitor, in Japanese patients with endogenous Cushing's syndrome other than Cushing's disease.
AIDS Dementia Complex
Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection?
Albuminuria
Elevated fasting glucose and albuminuria may be a marker for all-cause mortality in Indigenous adults in North Queensland - a follow up study, 1998-2006.
Obesity, albuminuria, and gamma-glutamyl transferase predict incidence of hypertension in indigenous Australians in rural and remote communities in northern Australia.
Alcohol-Related Disorders
Identification of alcohol abuse using laboratory tests and a history of trauma.
Serum beta-hexosaminidase in young university students.
Alkalosis
Acid-base regulation of hepatic glutamine metabolism and ureagenesis: study with 15N.
Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver.
Alzheimer Disease
Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission?
Astrocytes and glutamate homeostasis in Alzheimer's disease: a decrease in glutamine synthetase but not in glutamate transporter-1 in the prefrontal cortex.
Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation.
Changes in the cellular distribution of glutamine synthetase in Alzheimer's disease.
Glutamate metabolizing enzymes in prefrontal cortex of Alzheimer's disease patients.
Glutamine synthetase (GS) expression is reduced in senile dementia of the Alzheimer type.
Glutamine synthetase in astrocytes from entorhinal cortex of the triple transgenic animal model of Alzheimer's disease is not affected by pathological progression.
Glutamine synthetase in cerebrospinal fluid, serum, and brain: a diagnostic marker for Alzheimer disease?
Glutamine synthetase, hemoglobin alpha-chain, and macrophage migration inhibitory factor binding to amyloid beta-protein: their identification in rat brain by a novel affinity chromatography and in Alzheimer's disease brain by immunoprecipitation.
Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients.
Neuronal expression of glutamine synthetase in Alzheimer's disease indicates a profound impairment of metabolic interactions with astrocytes.
On the mechanism of the inhibition of glutamine synthetase and creatine phosphokinase by methionine sulfoxide.
Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease.
Redox Proteomics: A Key Tool for New Insights into Protein Modification with Relevance to Disease.
Serum glutamine synthetase has no value as a diagnostic biomarker for Alzheimer's disease.
The neuroprotective effect of two statins: simvastatin and pravastatin on a streptozotocin-induced model of Alzheimer's disease in rats.
Total glutamine synthetase levels in cerebrospinal fluid of Alzheimer's disease patients are unchanged.
[Impaired cerebral glutamate metabolism in mental diseases (Alzheimer's disease, schizophrenia]
Amyloidosis
Ursodeoxycholic acid for treatment of cholestasis in patients with hepatic amyloidosis.
Amyotrophic Lateral Sclerosis
Effect of sex on lifespan, disease progression, and the response to methionine sulfoximine in the SOD1 G93A mouse model for ALS.
Anemia
A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors.
Enfuvirtide: a fusion inhibitor for the treatment of HIV infection.
Independent Prognostic Value of Serum Markers in Diffuse Large B-Cell Lymphoma in the Era of the NCCN-IPI.
Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist.
Liver lobe torsion in three adult rabbits.
Phase 1 Open-Label, Multicenter Study of First-in-Class ROR? Agonist LYC-55716 (Cintirorgon): Safety, Tolerability, and Preliminary Evidence of Antitumor Activity.
Anemia, Hypochromic
Mode of Action of the Toxin from Pseudomonas phaseolicola: I. Toxin Specificity, Chlorosis, and Ornithine Accumulation.
Anhedonia
Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy.
Arthritis
Cholecystic adenocarcinoma and pancreatic insulinomas in a goat.
Arthritis, Experimental
Association between tissue gamma-glutamyl-transferase and clinical markers of adjuvant arthritis in Lewis rats.
Arthritis, Rheumatoid
Diagnostic value of brush border enzymes of the proximal renal tubules in rheumatoid arthritis.
Liver chemistry abnormalities and leg oedema in rheumatoid arthritis.
The source and significance of raised serum enzymes in rheumatoid arthritis.
[Localization of carbohydrate component in human synovial lining cells with fluorescent lectins and enzyme digestion]
Arthrogryposis
A novel mutation in VPS33B gene causing a milder ARC syndrome phenotype with prolonged survival.
Astrocytoma
Electrophysiological and biochemical characterization of a continuous human astrocytoma cell line with many properties of well-differentiated astrocytes.
Gamma-glutamyl transferase expression in higher-grade astrocytic glioma.
Immunocytochemistry of cerebellar astrocytomas: with a special note on Rosenthal fibres.
Immunohistochemical Characterization of Spontaneous and Acrylonitrile-induced Brain Tumors in the Rat.
Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas.
Subependymal giant cell astrocytoma: a lesion with activated mTOR pathway and constant expression of glutamine synthetase.
Ataxia Telangiectasia
Identification of Three Small Molecules That Can Selectively Influence Cellular Manganese Levels in a Mouse Striatal Cell Model.
Atherosclerosis
Association of gamma-glutamyl transferase with subclinical coronary atherosclerosis and cardiac outcomes in non-alcoholics.
Gamma-glutamyl transferase and the risk of atherosclerosis and coronary heart disease.
Gamma-glutamyl transferase variability and risk of dementia: A nationwide study.
Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: the STEATO Study.
Increased concentration of serum gamma-glutamyl transferase in ischemic stroke patients.
Serum gamma-glutamyl transferase activity increased in patients with coronary artery ectasia.
Serum gamma-glutamyl transferase is a predictor of mortality in patients with acute myocardial infarction.
Atrial Fibrillation
Effects of Gamma-Glutamyl Transferase on Stroke Occurrence Mediated by Atrial Fibrillation.
Gamma-glutamyl transferase and atrial fibrillation in patients with coronary artery disease.
Gamma-glutamyl transferase predicts recurrences of atrial fibrillation after catheter ablation.
Liver enzymes are not directly involved in atrial fibrillation: a prospective cohort study.
Avitaminosis
Detection and incidence of B and C vitamin deficiency in alcohol-related illness.
Bacteremia
Risk factors for symptomatic venous thromboembolism during therapy for childhood acute lymphoblastic leukemia.
beta-Thalassemia
Hyperchloremic metabolic acidosis due to deferasirox in a patient with beta thalassemia major.
Biliary Atresia
Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants.
Gamma-glutamyl transferase in the diagnosis of biliary atresia.
Gene Expression Signatures Associated With Survival Times of Pediatric Patients With Biliary Atresia Identify Potential Therapeutic Agents.
Improvement in accuracy of gamma-glutamyl transferase for differential diagnosis of biliary atresia by correlation with age.
Interleukin-33 overexpression is associated with gamma-glutamyl transferase in biliary atresia.
Neonatal cholestasis: development of a diagnostic decision algorithm from multivariate predictive models.
Normal Gamma Glutamyl Transferase Levels at Presentation Predict Poor Outcome in Biliary Atresia.
Role of percutaneous liver biopsy in infantile cholestasis: cohort from Arabs.
The impact of serum total bilirubin, alanine transaminase and gamma-glutamyl transferase on survival of biliary atresia patients following Kasai procedure.
Bone Diseases
Clinical usefulness of the simultaneous localisation of the isoenzymes of alkaline phosphate and gamma-glutamyl transferase.
Brain Diseases
Evaluation of [13N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain.
GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.
Possible treatment of end-stage hyperammonemic encephalopathy by inhibition of glutamine synthetase.
Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo.
Valproate-induced hyperammonemic encephalopathy in the presence of topiramate.
Brain Edema
A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure.
Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis.
Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures.
Control of brain glutamine synthesis by NMDA receptors.
Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats.
Brain Infarction
Serum gamma-glutamyl transferase is associated with silent brain infarcts in a healthy population.
Brain Injuries
Mechanical Brain Injury Increases Cells' Production of Cystathionine ?-Synthase and Glutamine Synthetase, but Reduces Pax2 Expression in the Telencephalon of Juvenile Chum Salmon, Oncorhynchus keta.
Role of endothelins as mediators of injury-induced alterations of glial glutamate turnover.
Role of oxygen free radicals in carcinogenesis and brain ischemia.
Brain Injuries, Traumatic
Focal Unilateral Traumatic brain injury Causes Delayed Neurodegenerative Changes in the Brain of Rats.
Brain Ischemia
Analysis of serum metabolites for the discovery of amino acid biomarkers and the effect of galangin on cerebral ischemia.
Brain glutamine synthetase increases following cerebral ischemia in the rat.
Neuroprotective effects of ischemic postconditioning on global brain ischemia in rats through upregulation of hippocampal glutamine synthetase.
Brain Neoplasms
The role of glutamine synthetase in the diagnosis of cerebral tumours.
Breast Neoplasms
A profile of serum CA 15-3, carcinoembryonic antigen, alkaline phosphatase, and gamma-glutamyl transferase levels in patients with breast cancer.
Aspects of glutamine metabolism in human tumour cells.
Circulating gamma-glutamyl transferase and development of specific breast cancer subtypes: findings from the Apolipoprotein Mortality Risk (AMORIS) cohort.
Complex biochemical analysis of human breast tumor tissue.
Correlation Between Gamma-Glutamyl Transferase Activity and Glutathione Levels in Molecular Subgroups of Breast Cancer.
Early diagnosis of breast cancer dissemination by tumor markers follow-up and method of prediction.
gamma-Glutamyl transferase and breast cancer risk.
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model.
Regulation of glutamine synthetase in human breast carcinoma cells and experimental tumors.
The correlation of antioxidant levels of breast cancer: A case controlled study.
The Predictive Value of Pre-therapeutic Serum Gamma-glutamyl transferase in Efficacy and Adverse Reactions to Neoadjuvant Chemotherapy among Breast Cancer Patients.
Bundle-Branch Block
[A patient with muscle pain after a journey to the tropics. Myocardial involvement in proximal myotonic myopathy]
Carcinogenesis
Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin.
Cell lineages and oval cell progenitors in rat liver development.
Glutamine synthetase promotes tumor invasion in hepatocellular carcinoma through mediating epithelial-mesenchymal transition.
Relationship between serum gamma-glutamyl transferase level and colorectal adenoma.
Relative merits of immunohistochemical demonstrations of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of gamma-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats.
Carcinoma
Differences in the enzymatic nature and the sugar-chain structure of gamma-glutamyl transferase between normal and carcinomatous human kidney and prostate.
Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol.
Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum.
Hepatic impairment during simultaneous administration of medroxyprogesterone acetate and tamoxifen in the treatment of endometrial and ovarian carcinoma.
Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers: a tricky aspect of a conditional knockout mouse model.
Peri-tumoral hyperintensity on hepatobiliary phase of gadoxetic acid-enhanced MRI in hepatocellular carcinomas: correlation with peri-tumoral hyperplasia and its pathological features.
Present and future possibilities for early diagnosis of hepatocellular carcinoma.
Roles of Combined Glypican-3 and Glutamine Synthetase in Differential Diagnosis of Hepatocellular Lesions.
Serum alkaline-stable acid thiol proteinase--a possible marker for primary liver carcinoma.
Serum gamma glutamyl-transferase is a sensitive but unspecific marker of metastatic renal cell carcinoma.
Stauffer's syndrome variant with cholestatic jaundice: a case report.
Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.
Update on the pathology of liver neoplasms.
[Specificity of glutamine metabolism in pre-tumorous diseases and cancer of the human stomach]
Carcinoma, Ehrlich Tumor
Changes in mRNAs for enzymes of glutamine metabolism in the tumor-bearing mouse.
Carcinoma, Endometrioid
Association of the immunohistochemical detection of gamma-glutamyl transferase expression with clinicopathological findings in postmenopausal women with endometrioid adenocarcinoma of the uterus.
Carcinoma, Hepatocellular
A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor.
A-G Score Associated With Outcomes in Solitary Hepatocellular Carcinoma Patients After Hepatectomy.
Abnormal dietary regulation of glutamine synthetase in Morris hepatomas.
Abnormal dietary regulation of glutamine synthetase in rat hepatomas.
Abnormal expression of hepatoma specific gamma-glutamyl transferase and alteration of gamma-glutamyl transferase gene methylation status in patients with hepatocellular carcinoma.
An examination of the relative resistances to aflatoxin B1 and susceptibilities to gamma-glutamyl p-phenylene diamine mustard of gamma-glutamyl transferase negative and positive cell lines.
Application of Immunohistochemistry in the Pathological Diagnosis of Liver Tumors.
Baseline gamma-glutamyl transferase levels strongly correlate with hepatocellular carcinoma development in non-cirrhotic patients with successful hepatitis C virus eradication.
Chemerin reverses the malignant phenotype and induces differentiation of human hepatoma SMMC7721 cells.
Clonal differences in glutamine synthetase activity of hepatoma cells. Effects of glutamine and dexamethasone.
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
Concomitant use of heat-shock protein 70, glutamine synthetase and glypican-3 is useful in diagnosis of HBV-related hepatocellular carcinoma with higher specificity and sensitivity.
Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma.
Correlation of exon 3 ?-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma.
Correlation of O4-ethyldeoxythymidine accumulation, hepatic initiation and hepatocellular carcinoma induction in rats continuously administered diethylnitrosamine.
Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet.
Diagnostic Value of Glypican3, Heat Shock Protein 70 and Glutamine Synthetase in Hepatocellular Carcinoma Arising in Cirrhotic and Non-Cirrhotic Livers.
Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein.
Diagnostic value of serum gamma-glutamyl transferase isoenzyme for hepatocellular carcinoma: a 10-year study.
Effect of glutamine on the degradation of glutamine synthetase in hepatoma tissue-culture cells.
Effects of glutamine, methionine sulfone and dexamethasone on rates of synthesis of glutamine synthetase in cultured hepatoma cells.
Electrophoretic studies of serum gamma-glutamyl transferase from patients with hepatoma.
Enhanced degradation of oxidized glutamine synthetase in vitro and after microinjection into hepatoma cells.
Evaluation of tumour necrosis factor-alpha, soluble P-selectin, gamma-glutamyl transferase, glutathione S-transferase-pi and alpha-fetoprotein in patients with hepatocellular carcinoma before and during chemotherapy.
Expression level of glutamine synthetase is increased in hepatocellular carcinoma and liver tissue with cirrhosis and chronic hepatitis B.
Functional activity of human hepatoma cells transfected with adenovirus-mediated hepatocyte nuclear factor (HNF)-4 gene.
Gamma-glutamyl transferase in ascitic fluid in primary hepatoma.
Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum.
Glucocorticoid induced expression of glutamine synthetase in hepatoma cells.
Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma.
Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts.
Glutamine synthetase and glutaminase activities in various hepatoma cells.
Glutamine synthetase as an early marker for hepatocellular carcinoma based on proteomic analysis of resected small hepatocellular carcinomas.
Glutamine synthetase immunostaining correlates with pathologic features of hepatocellular carcinoma and better survival after radiofrequency thermal ablation.
Glutamine synthetase mediates sorafenib sensitivity in ?-catenin-active hepatocellular carcinoma cells.
Glutamine synthetase predicts adjuvant TACE response in hepatocellular carcinoma.
Glutamine synthetase promotes tumor invasion in hepatocellular carcinoma through mediating epithelial-mesenchymal transition.
Glutamine Synthetase, Heat shock Protein-70, and Glypican-3 in Intrahepatic Cholangiocarcinoma and Tumors Metastatic to Liver.
Glutamine, insulin and glucocorticoids regulate glutamine synthetase expression in C2C12 myotubes, Hep G2 hepatoma cells and 3T3 L1 adipocytes.
Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells.
Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival.
Hepatocellular carcinoma arising in a pigmented telangiectatic adenoma with nuclear ?-catenin and glutamine synthetase positivity: case report and review of the literature.
Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor.
Hepatoma-related gamma-glutamyl transferase in laboratory or clinical diagnosis of hepatocellular carcinoma.
High Levels of Gamma-Glutamyl Transferase and Indocyanine Green Retention Rate at 15?min as Preoperative Predictors of Tumor Recurrence in Patients With Hepatocellular Carcinoma.
Histopathological characteristics of glutamine synthetase-positive hepatic tumor lesions in a mouse model of spontaneous metabolic syndrome (TSOD mouse).
Immunoexpression of Heat Shock Protein 70, Glypican 3, Glutamine Synthetase, and Beta-Catenin in Hepatocellular Carcinoma After Liver Transplantation: Association Between Positive Glypican 3 and Beta-Catenin With the Presence of Larger Nodules.
Improving pathological early diagnosis and differential biomarker value for hepatocellular carcinoma via RNAscope technology.
In situ determination of the molecular weight of hepatic gamma-glutamyl transferase and gamma-glutamyl hydrolase activities.
Increased expression and phosphorylation of liver glutamine synthetase in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.
Involvement of protein synthesis in the post-translational control of glutamine synthetase activity of cultured hepatoma cells.
L-Asparaginase and Inhibitors of Glutamine Synthetase Disclose Glutamine Addiction of ?-Catenin-Mutated Human Hepatocellular Carcinoma Cells.
Lipid peroxidation and activities of tyrosine aminotransferase and glutamine synthetase in hepatoma and glioma cells grown in bovine colostrum-supplemented medium.
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Modulation of the agonist activity of antisteroids by a novel cis-acting element.
Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells.
Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents.
Position Is Destiny: Metabolism and Cell Identity.
Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma.
Preoperative serum gamma-glutamyl transferase to alanine aminotransferase ratio is a convenient prognostic marker for Child-Pugh A hepatocellular carcinoma after operation.
Prognostic significance of glutamine synthetase expression in unifocal advanced hepatocellular carcinoma.
Prognostic significance of serum gamma-glutamyl transferase in patients with intermediate hepatocellular carcinoma treated with transcatheter arterial chemoembolization.
R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells.
Reappraisal of diagnostic significance of a hepatoma-specific band of serum gamma-glutamyl transferase.
Regulation of glutamine synthetase activity of hepatoma tissue culture cells by glutamine and dexamethasone.
Regulation of glutamine synthetase by dexamethasone in hepatoma tissue culture cells.
Regulation of the degradation of 125 I-labeled glutamine synthetase introduced into cultured hepatoma cells by erythrocyte ghost-mediated injection.
Role of the nucleus in the glutamine-dependent degradation of glutamine synthetase in cultured hepatoma cells.
Roles of Combined Glypican-3 and Glutamine Synthetase in Differential Diagnosis of Hepatocellular Lesions.
Specificity of the glutamine-binding site involved in the reguation of glutamine-synthetase activity in hepatoma tissue-culture cells.
The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma.
The turnover of hepatoma cell gamma-glutamyl transferase.
Tissue Biomarkers in Hepatocellular Tumors: Which, When, and How.
Transcriptomic and Proteomic Analysis of Steatohepatitic Hepatocellular Carcinoma Reveals Novel Distinct Biologic Features.
Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation.
Tumour-associated isoenzymes of gamma-glutamyl transferase in the serum of patients with hepatocellular carcinoma.
Utility of an Immunohistochemical Panel Consisting of Glypican-3, Heat-shock Protein-70, and Glutamine Synthetase in the Distinction of Low-grade Hepatocellular Carcinoma From Hepatocellular Adenoma.
[Effect of hydrocortisone on gamma-glutamyl transferase activity of the rat liver and hepatoma]
Carcinoma, Neuroendocrine
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of gamma-glutamyl transferase in patients with metastatic non-small cell lung cancer.
TRAP1 Inhibition Increases Glutamine Synthetase Activity in Glutamine Auxotrophic Non-small Cell Lung Cancer Cells.
Carcinoma, Renal Cell
Differences in the enzymatic nature and the sugar-chain structure of gamma-glutamyl transferase between normal and carcinomatous human kidney and prostate.
Serum gamma glutamyl-transferase is a sensitive but unspecific marker of metastatic renal cell carcinoma.
Stauffer's syndrome variant with cholestatic jaundice: a case report.
Carcinoma, Squamous Cell
Present and future possibilities for early diagnosis of hepatocellular carcinoma.
Carcinosarcoma
[The regulatory action of dipeptide "Deglutam" on the glutamine metabolized enzymes in the carcinosarcoma SM-1 cells]
Cardiovascular Diseases
Alcohol intake and variations in blood pressure by day of examination.
Association of coronary artery calcification and serum gamma-glutamyl transferase in Korean.
Elevated gamma-glutamyl transferase is associated with subclinical inflammation independent of cardiometabolic risk factors in an asymptomatic population: a cross-sectional study.
Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study.
Gamma-glutamyl transferase and cardiovascular disease.
Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease: The Gut and Obesity Asia initiative.
Gamma-glutamyl transferase and metabolic risk factors for cardiovascular disease.
Gamma-glutamyl transferase variability and the risk of hospitalisation for heart failure.
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
Multiple biomarkers and their relative contributions to identifying metabolic syndrome.
Prognostic value of long-term gamma-glutamyl transferase variability in individuals with diabetes: a nationwide population-based study.
Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study.
Serum gamma-glutamyl transferase activity is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome.
Serum gamma-glutamyl transferase activity predicts future development of metabolic syndrome defined by 2 different criteria.
Serum gamma-glutamyl transferase is associated with plasma total homocysteine in Japanese patients with type 2 diabetes.
Serum levels of gamma-glutamyl transferase are associated with cardiovascular disease in obstructive sleep apnea syndrome.
Vital capacity and selected metabolic diseases in middle-aged Japanese men.
Carotid Artery Diseases
Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: the STEATO Study.
Multifocal fatty liver disease, insulin resistance and carotid atherosclerosis: exploring the interrelated relationship.
Cataract
Effect of vanadyl sulfate feeding on susceptibility to peroxidative change in diabetic rats.
Cerebral Hemorrhage
Risk factors for spontaneous intracerebral hemorrhage.
Cerebral Infarction
Clinical aspects of early increase in serum gamma-glutamyl transferase in cerebral infarction.
Gamma-glutamyl transferase levels in patients with acute ischemic stroke.
L-NAME combats excitotoxicity and recuperates neurological deficits in MCAO/R rats.
Cerebrovascular Disorders
Serum gamma-glutamyl transferase is associated with silent brain infarcts in a healthy population.
Chagas Disease
L-Glutamine uptake is developmentally regulated and is involved in metacyclogenesis in Trypanosoma cruzi.
Chemical and Drug Induced Liver Injury
A Multiple Logistic Regression Model Based on Gamma-Glutamyl Transferase as a Biomarker for Early Prediction of Drug-Induced Liver Injury in Vietnamese Patients.
Cholangiocarcinoma
Glutamine Synthetase, Heat shock Protein-70, and Glypican-3 in Intrahepatic Cholangiocarcinoma and Tumors Metastatic to Liver.
Serum gamma-glutamyl transferase levels affect the prognosis of patients with intrahepatic cholangiocarcinoma who receive postoperative adjuvant transcatheter arterial chemoembolization: A propensity score matching study.
The Role of Genetic and Immune Factors for the Pathogenesis of Primary Sclerosing Cholangitis in Childhood.
Cholangitis
Consideration of endoscopic retrograde cholangiopancreatography in cases of acute biliary pancreatitis.
Cysteinyl leukotrienes in the bile of patients with obstructive jaundice.
Risk factors and prognostic effects of cholangitis after Kasai procedure in biliary atresia patients: A retrospective clinical study.
Cholangitis, Sclerosing
IgG4 subclass and gamma-glutamyl transferase in children with ulcerative colitis with primary sclerosing cholangitis and without sclerosing cholangitis.
[Treatment of cholestatic liver disease]
Cholecystitis, Acute
Consideration of endoscopic retrograde cholangiopancreatography in cases of acute biliary pancreatitis.
Choledochal Cyst
[Endoscopic transpapillary splitting of a choledochocele (author's transl)]
Cholelithiasis
Cholelithiasis, Cholecystectomy, and Liver Disease.
Cholestasis
A novel mutation in VPS33B gene causing a milder ARC syndrome phenotype with prolonged survival.
Byler-like familial cholestasis in an extended kindred.
Cholestasis After Pediatric Liver Transplantation-Recurrence of a Progressive Familial Intrahepatic Cholestasis Phenotype as a Rare Differential Diagnosis: A Case Report.
Cholestasis in a patient with gallstones and a normal gamma-glutamyl transferase.
Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19.
Epidemiological characteristics and clinical manifestations of hepatitis E virus infection in Bulgaria: A report on 20 patients.
Expression of intrahepatic CD3, CD4, and CD8 T cells in biliary atresia.
Favorable effect of 4-phenylacetate on liver functions attributable to enhanced bile salt export pump expression in ornithine transcarbamylase-deficient children.
High hepatic gamma-glutamyltransferase (gamma-GT) activity with normal serum gamma-GT in children with progressive idiopathic cholestasis.
Hyaluronic acid: Additional biochemical marker in the diagnosis of biliary atresia.
Influence of pre-, intra- and post-operative parameters of donor liver on the outcome of isolated human hepatocytes.
Lipoprotein-X in patients with cirrhosis: its relationship to cholestasis and hypercholesterolemia.
Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.
MYO5B mutations cause cholestasis with normal serum gamma-glutamyl transferase activity in children without microvillous inclusion disease.
Nutritional evaluation of children with chronic cholestatic disease.
Pleural effusion resulting from malignant hepatoblastoma in a horse.
Primary biliary cirrhosis.
Prognosis, with evaluation of general biochemistry, of liver disease in lymphoedema cholestasis syndrome 1 (LCS1/Aagenaes syndrome).
Progressive familial intrahepatic cholestasis in Malaysian patients--a report of five cases.
Recurrent acalculous cholecystitis and sclerosing cholangitis in a patient with X-linked hyper-immunoglobulin M syndrome.
Role of percutaneous liver biopsy in infantile cholestasis: cohort from Arabs.
Serum enzymes associated with cholestasis.
Small bowel dilation in children with short bowel syndrome is associated with mucosal damage, bowel-derived bloodstream infections, and hepatic injury.
The Mystery of Episodic Recurrent Jaundice in a Young Male: Cholestasis With a Normal Gamma-Glutamyl Transferase.
Value of serum alkaline phosphatase, aminotransferases, gamma-glutamyl transferase, leucine aminopeptidase, and bilirubin in the distinction between benign and malignant diseases causing jaundice and cholestasis: results from a prospective study.
[The electrophoretic pattern of gamma-glutamyl transferase in serum and its alteration by chylomicrons (author's transl)]
Cholestasis, Intrahepatic
ATP8B1 and ABCB11 analysis in 62 children with normal gamma-glutamyl transferase progressive familial intrahepatic cholestasis (PFIC): phenotypic differences between PFIC1 and PFIC2 and natural history.
Benign recurrent intrahepatic cholestasis.
Biallelic loss-of-function ZFYVE19 mutations are associated with congenital hepatic fibrosis, sclerosing cholangiopathy and high-GGT cholestasis.
MYO5B mutations cause cholestasis with normal serum gamma-glutamyl transferase activity in children without microvillous inclusion disease.
Colitis, Ulcerative
IgG4 subclass and gamma-glutamyl transferase in children with ulcerative colitis with primary sclerosing cholangitis and without sclerosing cholangitis.
Colonic Neoplasms
Analysis of differentially expressed genes in human hepatocellular carcinoma using suppression subtractive hybridization.
Increased gamma-glutamyl transferase activity in human colon cancer.
Colorectal Neoplasms
Locoregional therapy and systemic cetuximab to treat colorectal liver metastases.
Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.
Value of serum-5-nucleotidase, alkaline phosphatase and gamma-glutamyl transferase for prediction of liver metastases preoperatively in colorectal cancer.
Coma
Acute metabolic effects of ammonia on the enzymes of glutamate metabolism in isolated astroglial cells.
Serum gamma-glutamyl transferase activity in diabetic ketoacidosis and non-ketotic hyperosmolar coma.
Communicable Diseases
Elevated Values of Clinically Relevant Transferases Induced by Imported Infectious Diseases: A Controlled Cross-Sectional Study of 14,559 Diseased German Travelers Returning from the Tropics and Subtropics.
Tissue enzyme activities in the loggerhead sea turtle (Caretta caretta).
Communicable Diseases, Imported
Elevated Values of Clinically Relevant Transferases Induced by Imported Infectious Diseases: A Controlled Cross-Sectional Study of 14,559 Diseased German Travelers Returning from the Tropics and Subtropics.
Coronary Artery Disease
Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis.
Association of gamma-glutamyl transferase with subclinical coronary atherosclerosis and cardiac outcomes in non-alcoholics.
Gamma-glutamyl transferase and atrial fibrillation in patients with coronary artery disease.
Gamma-glutamyl transferase and prognosis in patients with coronary artery disease.
Gamma-glutamyl transferase to albumin ratio as a novel predictor of bleeding events and mortality in patients after percutaneous coronary intervention: A retrospective cohort study.
Gamma-glutamyl transferase to albumin ratio can predict severity of coronary artery disease detected by coronary computed tomography angiography.
Increased gamma-glutamyl transferase level is associated with absence of coronary collateral vessels in patients with acute coronary syndrome: an observational study.
Prognostic value of gamma-glutamyl transferase in patients with diabetes mellitus and coronary artery disease.
Risk stratification in stable coronary artery disease: superiority of N-terminal pro B-type natriuretic peptide over high-sensitivity C-reactive protein, gamma-glutamyl transferase, and traditional risk factors.
Role of gamma-glutamyl transferase (GGT) in diagnosis of impaired glucose tolerance and metabolic syndrome: a prospective cohort research from the Kerman Coronary Artery Disease Risk Study (KERCADRS).
Serum gamma-glutamyl transferase and mortality in persons undergoing coronary angiography-The Ludwigshafen Risk and Cardiovascular Health Study.
Serum gamma-glutamyl transferase: a novel biomarker for coronary artery disease.
Serum level of gamma-glutamyl transferase as a biomarker for predicting stenosis severity in patients with coronary artery disease.
The relation of serum gamma-glutamyl transferase levels with coronary lesion complexity and long-term outcome in patients with stable coronary artery disease.
The relationship between gamma-glutamyl transferase levels and coronary plaque burdens and plaque structures in young adults with coronary atherosclerosis.
Coronary Disease
A comparison of gamma-glutamyl transferase and alkaline phosphatase as prognostic markers in patients with coronary heart disease.
Gamma-glutamyl transferase and the risk of atherosclerosis and coronary heart disease.
Genetic variant at the GLUL locus predicts all-cause mortality in patients with type 2 diabetes.
Serum Gamma-glutamyl Transferase Concentration Within the Reference Range is Related to the Coronary Heart Disease Risk Prediction in Korean Men: Analysis of the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011).
COVID-19
Abnormal Liver Biochemistry Tests and Acute Liver Injury in COVID-19 Patients: Current Evidence and Potential Pathogenesis.
Clinical features and mechanism of liver injury in patients with mild or moderate coronavirus disease 2019.
Corona Virus Disease 2019 patients with different disease severity or age range: A single-center study of clinical features and prognosis.
Coronavirus disease (COVID-19) and the liver: a comprehensive systematic review and meta-analysis.
How Patients With Chronic Liver Diseases Succeed to Deal With COVID-19?
Relationship Between COVID-19 Infection and Liver Injury: A Review of Recent Data.
Cystitis
Risk of Renal Function Decline in Patients with Ketamine-Associated Uropathy.
Cysts
Carbohydrate antigen 19-9 is significantly elevated in autosomal dominant polycystic kidney disease.
Isolation and culture of rhesus monkey pancreatic ductules and ductule-like epithelium.
Occult cystobiliary communication presenting as postoperative biliary leakage after hydatid liver surgery: are there significant preoperative clinical predictors?
Plasticity of epithelial cells derived from human normal and ADPKD kidneys in primary cultures.
Results of alcohol and albendazole injections in hepatic hydatidosis: experimental study.
Cytomegalovirus Infections
MYO5B mutations cause cholestasis with normal serum gamma-glutamyl transferase activity in children without microvillous inclusion disease.
Dehydration
Amino acid pattern and glutamate metabolism during dehydration stress in the 'resurrection' plant Sporobolus stapfianus: a comparison between desiccation-sensitive and desiccation-tolerant leaves.
Ammonium metabolism in Selaginella bryopteris in response to dehydration-rehydration and characterisation of desiccation tolerant, thermostable, cytosolic glutamine synthetase from plant.
Combined effects of water stress and high temperature on photosynthesis, nitrogen metabolism and lipid peroxidation of a perennial grass Leymus chinensis.
Corrigendum to: Ammonium metabolism in Selaginella bryopteris in response to dehydration-rehydration and characterisation of desiccation tolerant, thermostable, cytosolic glutamine synthetase from plant.
Effects of water stress on the gas exchange, the activities of some enzymes of carbon and nitrogen metabolism, and on the pool sizes of some organic acids in maize leaves.
Ethanolic dehydration and its effect on membrane-bound enzymes of Chlorogloeopsis fritschii and Chlorella pyrenoidosa.
Nitric Oxide Signal, Nitrogen Metabolism, and Water Balance Affected by ?-Aminobutyric Acid (GABA) in Relation to Enhanced Tolerance to Water Stress in Creeping Bentgrass.
Nitrogen supply enhances the physiological resistance of Chinese fir plantlets under polyethylene glycol (PEG)-induced drought stress.
Proteomic analyses unraveling water stress response in two Eucalyptus species originating from contrasting environments for aridity.
Response of transgenic poplar overexpressing cytosolic glutamine synthetase to phosphinothricin.
Transgenic poplar characterized by ectopic expression of a pine cytosolic glutamine synthetase gene exhibits enhanced tolerance to water stress.
Dementia
Gamma-Glutamyl Transferase Variability and Risk of Dementia in Diabetes Mellitus: A Nationwide Population-Based Study.
Gamma-glutamyl transferase variability and risk of dementia: A nationwide study.
Immunoassay for serum glutamine synthetase in serum: development, reference values, and preliminary study in dementias.
Diabetes Mellitus
Combined associations of liver enzymes and obesity with diabetes mellitus prevalence: The Tohoku Medical Megabank Community-based Cohort Study.
Downregulation of MicroRNA 29a/b exacerbated diabetic retinopathy by impairing the function of Müller cells via Forkhead box protein O4.
Effects of hepatitis B virus infection, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase on prediabetes and diabetes mellitus: A cohort study.
Gamma-glutamyl transferase and risk of type II diabetes: an updated systematic review and dose-response meta-analysis.
Gamma-Glutamyl Transferase Variability and Risk of Dementia in Diabetes Mellitus: A Nationwide Population-Based Study.
High-Glucose and S100B Stimulate Glutamate Uptake in C6 Glioma Cells.
Non-linear relationship between gamma-glutamyl transferase and type 2 diabetes mellitus risk: secondary analysis of a prospective cohort study.
Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma.
Prognostic value of gamma-glutamyl transferase in patients with diabetes mellitus and coronary artery disease.
Role of gamma-glutamyl transferase (GGT) in diagnosis of impaired glucose tolerance and metabolic syndrome: a prospective cohort research from the Kerman Coronary Artery Disease Risk Study (KERCADRS).
Serum gamma-glutamyl transferase level and diabetes mellitus among US adults.
The association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow-up.
The Dose-Response Relationship between Gamma-Glutamyl Transferase and Risk of Diabetes Mellitus Using Publicly Available Data: A Longitudinal Study in Japan.
[Urinary enzymes as a marker of the preclinical stage of diabetic nephropathy]
Diabetes Mellitus, Experimental
[Glutamine synthetase and glutaminase activity in the brain and liver homogenates and subcellular fractions of rats with alloxan diabetes (3)]
[Rat brain and liver glutamine synthetase and gamma-glutamyltransferase activity in alloxan diabetes (IV)]
Diabetes Mellitus, Type 1
[Urinary enzymes in the assessment of the early stage of kidney involvement in psoriasis and diabetes mellitus]
Diabetes Mellitus, Type 2
Correlates of Insulin-Stimulated glucose Disposal in Recent Onset Type 1 and Type 2 Diabetes.
Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes.
Genetic variant at the GLUL locus predicts all-cause mortality in patients with type 2 diabetes.
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
Non-linear relationship between gamma-glutamyl transferase and type 2 diabetes mellitus risk: secondary analysis of a prospective cohort study.
Progression of Fatty Liver Disease in Children Receiving Standard of Care Lifestyle Advice.
Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study.
Relationship between gamma-glutamyl transferase and glucose intolerance in first degree relatives of type 2 diabetics patients.
Relationship between inflammatory parameters and cardiovascular and lifestyle factors in the Mugello study oldest old.
Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study.
Serum gamma-glutamyl transferase is associated with plasma total homocysteine in Japanese patients with type 2 diabetes.
Serum gamma-glutamyl transferase, ferritin and the risk of type 2 diabetes in women from a Chinese minority.
The association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow-up.
Diabetes, Gestational
Higher level of GGT during mid-pregnancy is associated with increased risk of gestational diabetes mellitus.
Influences of pregravid liver enzyme levels on the development of gestational diabetes mellitus.
Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.
The association of plasma levels of liver enzymes and risk of gestational diabetes mellitus: a systematic review and dose-response meta-analysis of observational studies.
Diabetic Ketoacidosis
Glutamine synthetase activity of muscle in acidosis.
Serum gamma-glutamyl transferase activity in diabetic ketoacidosis and non-ketotic hyperosmolar coma.
Diabetic Nephropathies
[Urinary enzymes as a marker of the preclinical stage of diabetic nephropathy]
Diabetic Retinopathy
Effect of pigment epithelium derived factor on the expression of glutamine synthetase in early phase of experimental diabetic retinopathy.
Digestive System Diseases
Biallelic loss-of-function ZFYVE19 mutations are associated with congenital hepatic fibrosis, sclerosing cholangiopathy and high-GGT cholestasis.
Can we use serum gamma-glutamyl transferase levels to predict early mortality in stroke?
Diagnostic value of serum gamma-glutamyl transferase and alkaline phosphatase activities in hepatobiliary disease in the cat.
Diagnostic values of fasting and postprandial concentrations in serum of 3 alpha-hydroxy-bile acids and gamma-glutamyl transferase in hepatobiliary disease.
Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortality.
Lack of value of serum gamma-glutamyl transferase in the diagnosis of hepatobiliary disease.
Tumour-associated isoenzymes of gamma-glutamyl transferase in the serum of patients with hepatocellular carcinoma.
Value of liver biopsy for the rapid diagnosis of infection in human immunodeficiency virus-infected patients who have unexplained fever and elevated serum levels of alkaline phosphatase or gamma-glutamyl transferase.
[Increased liver enzymes: what should be done?]
Diplopia
The tolerability and safety profile of eslicarbazepine acetate in neurological disorders.
Down Syndrome
Amniotic fluid gamma-glutamyl transferase activity in trisomy 21 and neural tube defects.
Dysarthria
The tolerability and safety profile of eslicarbazepine acetate in neurological disorders.
Dyslipidemias
Grape seed and skin extract as an adjunct to xenical therapy reduces obesity, brain lipotoxicity and oxidative stress in high fat diet fed rats.
Eczema
The association of milk-solid production during the current lactation with liver damage due to presumptive ingestion of spores from Pithomyces chatarum by dairy cattle.
Embolism
Elevated gamma glutamyl transferase levels are associated with the location of acute pulmonary embolism. Cross-sectional evaluation in hospital setting.
Encephalomyelitis, Autoimmune, Experimental
Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis.
End Stage Liver Disease
Hepatic encephalopathy: An update of pathophysiologic mechanisms.
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide.
Endotoxemia
Adaptive regulation in skeletal muscle glutamine metabolism in endotoxin-treated rats.
Glucocorticoids regulate intestinal glutamine synthetase gene expression in endotoxemia.
Induction of muscle glutamine synthetase gene expression during endotoxemia is adrenal gland dependent.
Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin.
Sepsis increases lung glutamine synthetase expression in the tumor-bearing host.
Eosinophilia
Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees.
Enfuvirtide: a fusion inhibitor for the treatment of HIV infection.
[Hepatobiliary System Diseases as the Predictors of Psoriasis Progression].
Epilepsies, Myoclonic
Two Siblings With Valproate-Related Hyperammonemia and Novel Mutations in Glutamine Synthetase (GLUL) Treated With Carglumic Acid.
Epilepsies, Partial
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity.
Epilepsy
A sub-threshold dose of pilocarpine increases glutamine synthetase in reactive astrocytes and enhances the progression of amygdaloid-kindling epilepsy in rats.
A Transient Upregulation of Glutamine Synthetase in the Dentate Gyrus Is Involved in Epileptogenesis Induced by Amygdala Kindling in the Rat.
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Alterations in glutamine synthetase activity by FeCl2-induced focal and kindled amygdaloid seizures.
Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy.
Astrocytes and Glutamine Synthetase in Epileptogenesis.
Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus.
Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy.
Circumstantial evidence for a role of glutamine-synthetase in suicide.
Comparison of glutamine synthetases from brains of genetically epilepsy prone and genetically epilepsy resistant rats.
Corrigendum to 'Angiocentric glioma-associated seizures: The possible role of EATT2, pyruvate carboxylase and glutamine synthetase [Seizure: European Journal of Epilepsy 86 (2021) 152-154].
Decreased glutamine synthetase, increased citrulline-nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model.
Epilepsy in glioblastoma multiforme: correlation with glutamine synthetase levels.
Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy.
Expression of glutamine synthetase in balloon cells: a basis of their antiepileptic role?
Glut1 deficiency (G1D): Epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype.
Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?
Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy.
Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme.
Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy.
Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy.
Manganese and epilepsy: brain glutamine synthetase and liver arginase activities in genetically epilepsy prone and chronically seizured rats.
Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy.
Phenotypic differences between fast and slow methionine sulfoximine-inbred mice: seizures, anxiety, and glutamine synthetase.
Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy.
Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition.
Reduced glutamine synthetase in hippocampal areas with neuron loss in temporal lobe epilepsy.
Regulation of astrocyte glutamine synthetase in epilepsy.
Roles of Glutamine Synthetase Inhibition in Epilepsy.
Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration.
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity.
The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats A video-intracranial electroencephalographic study.
The Glutamate-Glutamine Cycle in Epilepsy.
Unchanged glutamine synthetase activity and increased NMDA receptor density in epileptic human neocortex: implications for the pathophysiology of epilepsy.
Epilepsy, Absence
Specific alteration in the expression of glial fibrillary acidic protein, glutamate dehydrogenase, and glutamine synthetase in rats with genetic absence epilepsy.
Epilepsy, Temporal Lobe
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Astrocytes and Glutamine Synthetase in Epileptogenesis.
Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus.
Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy.
Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy.
Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?
Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy.
Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy.
Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy.
Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition.
Reduced glutamine synthetase in hippocampal areas with neuron loss in temporal lobe epilepsy.
The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats A video-intracranial electroencephalographic study.
Unchanged glutamine synthetase activity and increased NMDA receptor density in epileptic human neocortex: implications for the pathophysiology of epilepsy.
Epileptic Syndromes
Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy.
Epiretinal Membrane
Expression of glutamine synthetase and cell proliferation in human idiopathic epiretinal membrane.
Fibrocontractive Müller cell phenotypes in proliferative diabetic retinopathy.
Rabbit retinal Müller cells undergo antigenic changes in response to experimentally induced proliferative vitreoretinopathy.
Ultrastructural and immunocytochemical changes in retinal pigment epithelium, retinal glia, and fibroblasts in vitreous culture.
Esophageal and Gastric Varices
Prognostic factors for survival in patients with compensated cirrhosis and small hepatocellular carcinoma after percutaneous ethanol injection therapy.
Exanthema
Ceritinib plus Nivolumab in Patients with Advanced ALK-Rearranged Non-Small Cell Lung Cancer: Results of an Open-Label, Multicenter, Phase 1B Study.
Risk factors for coronary artery abnormalities in children with Kawasaki disease: a 10-year experience.
The tolerability and safety profile of eslicarbazepine acetate in neurological disorders.
Familial Primary Pulmonary Hypertension
Fatal hyperammonemia after orthotopic lung transplantation.
Fascioliasis
Seroepidemiology of human fascioliasis and its relationship with anti-Fasciola IgG and liver enzymes as biomarkers of pathogenicity.
Fatty Liver
Association between environmental exposure to cadmium and risk of suspected non-alcoholic fatty liver disease.
Associations between arterial structure and function and serum levels of liver enzymes in obese adolescents.
Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease.
Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial.
Effect of Soy Milk on Metabolic Status of Patients with Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial.
Estimation of gamma-glutamyl transferase as a suitable simple biomarker of the cardiovascular risk in children with non-alcoholic fatty liver disease.
External validation of fatty liver index for identifying ultrasonographic fatty liver in a large-scale cross-sectional study in Taiwan.
Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study.
Fruit Fiber Consumption Specifically Improves Liver Health Status in Obese Subjects under Energy Restriction.
Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011.
Gamma-glutamyl transferase: a novel cardiovascular risk biomarker.
Glucose and insulin responses to glucagon injection in dairy cows with ketosis and fatty liver.
Inverse Association between Serum 25-hydroxyvitamin D Levels and Risk of Suspected Non-Alcoholic Fatty Liver Disease in Obese Population.
Low levels of Lysosomal Acid Lipase (LAL) activity increases necroinflammation in adult patients with biopsy-proven metabolic associated fatty liver disease.
Metabolic and hepatic effects of bloodletting in dysmetabolic iron overload syndrome: A randomized controlled study in 274 patients.
Metabolic risk factors, genetic predisposition, and risk of severe liver disease in Chinese: a prospective study of 0.5 million people.
MRI of atherosclerosis and fatty liver disease in cholesterol fed rabbits.
Multifocal fatty liver disease, insulin resistance and carotid atherosclerosis: exploring the interrelated relationship.
Non-Alcoholic Fatty Liver Disease Modifies Serum Gamma-Glutamyl Transferase in Cigarette Smokers.
Nonalcoholic fatty liver disease and the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis: the hidden danger.
Obesity as a cause of "false-positive" alcohol misuse laboratory investigations.
Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women.
Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents.
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement.
Fatty Liver, Alcoholic
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
Fetal Alcohol Spectrum Disorders
Evaluation of serum gamma-glutamyl transferase as a screening method for excessive alcohol consumption during pregnancy.
Fibromatosis, Aggressive
Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue.
Focal Nodular Hyperplasia
A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor.
Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques.
Diagnostic challenges of focal nodular hyperplasia: interobserver variability, accuracy, and the utility of glutamine synthetase immunohistochemistry.
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma.
Glutamine Synthetase Immunoreactivity in Peritumoral Hyperplasia in Liver: ?Case Report of a Metastatic Paraganglioma With Focal Nodular Hyperplasia-Like Changes and Review of an Additional 54 Liver Masses.
Hepatocellular adenomas in a large community population, 2000 to 2010: reclassification per current World Health Organization classification and results of long-term follow-up.
Immunostaining of glutamine synthetase is a sensitive and specific marker for diagnosing focal nodular hyperplasia in needle biopsy.
Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology.
Update on the pathology of liver neoplasms.
Fragile X Syndrome
Gamma-glutamyl transferase activity in the amniotic fluid of fetuses with chromosomal aberrations and inborn errors of metabolism.
Gallbladder Diseases
?-glutamyl transferase-to-platelet ratio based nomogram predicting overall survival of gallbladder carcinoma.
Gallstones
Cholestasis in a patient with gallstones and a normal gamma-glutamyl transferase.
Gardner Syndrome
Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue.
Gastritis, Atrophic
[Specificity of glutamine metabolism in pre-tumorous diseases and cancer of the human stomach]
Gastrointestinal Neoplasms
The relationship between an inflammation-based prognostic score (Glasgow Prognostic Score) and changes in serum biochemical variables in patients with advanced lung and gastrointestinal cancer.
Gastroschisis
Amniotic fluid inflammatory proteins and digestive compounds profile in fetuses with gastroschisis undergoing amnioexchange.
Giardiasis
[Hepatobiliary System Diseases as the Predictors of Psoriasis Progression].
Glaucoma
alpha-Luminol prevents decreases in glutamate, glutathione, and glutamine synthetase in the retinas of glaucomatous DBA/2J mice.
Effects of acutely elevated hydrostatic pressure in the rat ex vivo retinal preparation.
Loss of glutamine synthetase immunoreactivity from the retina in canine primary glaucoma.
Glioblastoma
AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro.
Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma.
Epilepsy in glioblastoma multiforme: correlation with glutamine synthetase levels.
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.
Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme.
Glutamine synthetase gene expression in a glioblastoma cell-line of clonal origin: regulation by dexamethasone and dibutyryl cyclic AMP.
Glioma
A time-dependent increase in glial fibrillary acidic protein expression and glutamine synthetase activity in long-term subculture of the GL15 glioma cell line.
Alteration in morphology and induction of glutamine synthetase in rat glioma C6BU-1 cells cultured with prostaglandin D(2)-supplemented media.
Angiocentric glioma-associated seizures: The possible role of EATT2, pyruvate carboxylase and glutamine synthetase.
Effect of growth factors on the in vitro growth and differentiation of early and late passage C6 glioma cells.
Glucocorticoid stimulation of glutamine synthetase production in cultured rat glioma cells.
Glutamine synthetase functions as a negative growth regulator in glioma.
High-Glucose and S100B Stimulate Glutamate Uptake in C6 Glioma Cells.
Induction of glutamine synthetase by dibutyryl cyclic AMP in C-6 glioma cells.
Lipid peroxidation and activities of tyrosine aminotransferase and glutamine synthetase in hepatoma and glioma cells grown in bovine colostrum-supplemented medium.
MicroRNA-140-5p suppresses invasion and proliferation of glioma cells by targeting glutamate-ammonia ligase (GLUL).
Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions.
Platelet-activating factor increases glutamine synthetase activity in early and late passage C-6 glioma cells.
Responses in astrocytic C6 glioma cells to ethanol and dibutyryl cyclic AMP.
Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells.
[The effect of opioid peptides on a decreased proliferation and on an increased maturation rate of glioma C-6 cells manifested by enhanced marker enzyme activity]
Glomerulonephritis
[A method of separate determination of enzymuria associated with impairment of glomerular filtration in kidney tissue]
Glucose Intolerance
Combining Fasting Plasma Glucose with Gamma-glutamyl Transferase Improves the Sensitivity to Predict Incident Diabetes in Asian Indian Men with Impaired Glucose Tolerance.
Effects of supervised exercise on gamma-glutamyl transferase levels in patients with isolated impaired fasting glucose and those with impaired fasting glucose plus impaired glucose tolerance.
Relationship between gamma-glutamyl transferase and glucose intolerance in first degree relatives of type 2 diabetics patients.
Role of gamma-glutamyl transferase (GGT) in diagnosis of impaired glucose tolerance and metabolic syndrome: a prospective cohort research from the Kerman Coronary Artery Disease Risk Study (KERCADRS).
Sodium acetate prevents nicotine-induced cardiorenal dysmetabolism through uric acid/creatine kinase-dependent pathway.
glutamine synthetase deficiency
A Very Rare Etiology of Hypotonia and Seizures: Congenital Glutamine Synthetase Deficiency.
Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy.
Congenital glutamine deficiency with glutamine synthetase mutations.
Fatal hyperammonemia after orthotopic lung transplantation.
Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.
Glutamine synthetase deficiency in murine astrocytes results in neonatal death.
Hepatic glutamine synthetase deficiency in fatal hyperammonemia after lung transplantation.
Homozygous GLUL deletion is embryonically viable and leads to glutamine synthetase deficiency.
Hyperoxia-Induced Lung Injury in Gamma-Glutamyl Transferase Deficiency Is Associated with Alterations in Nitrosative and Nitrative Stress.
Impaired novelty acquisition and synaptic plasticity in congenital hyperammonemia caused by hepatic glutamine synthetase deficiency.
Inborn error of amino acid synthesis: Human glutamine synthetase deficiency.
MARS treatment for a patient presenting with acquired hepatic glutamine synthetase deficiency after orthotopic liver transplantation.
Minireview on Glutamine Synthetase Deficiency, an Ultra-Rare Inborn Error of Amino Acid Biosynthesis.
Natural course of glutamine synthetase deficiency in a 3year old patient.
Recent advances in amino acid and organic acid metabolism.
Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats.
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity.
The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain.
Two cytosolic glutamine synthetase isoforms play specific roles for seed germination and seed yield structure in Arabidopsis.
[Prenatal symptoms and diagnosis of inherited metabolic diseases].
Gout
[Glutamine synthetase activity in the liver in primary gout (author's transl)]
Granular Cell Tumor
Immunohistochemical Characterization of Spontaneous and Acrylonitrile-induced Brain Tumors in the Rat.
Granuloma
Intrahepatic IgG/IgM plasma cells ratio helps in classifying autoimmune liver diseases.
Hand-Foot Syndrome
Phase I trial of sorafenib following liver transplantation in patients with high-risk hepatocellular carcinoma.
Heart Failure
Biomarkers of Zinc and Copper Status and Associated Factors in Outpatients with Ischemic and Non-Ischemic Heart Failure.
Gamma-glutamyl transferase variability and the risk of hospitalisation for heart failure.
Histology and Glutamine Synthetase Immunoreactivity in Liver Biopsies From Patients With Congestive Heart Failure.
Serum gamma-glutamyl transferase and risk of heart failure in the community.
Uric Acid and Gamma-glutamyl Transferase Activity Are Associated With Left Ventricular Remodeling Indices in Patients With Chronic Heart Failure.
Uric acid and gamma-glutamyl transferase activity are associated with left ventricular remodeling indices in patients with chronic heart failure.
Hematemesis
Multiple Liver Nodules Mimicking Metastatic Disease as Initial Presentation of Multiple Myeloma.
Hematologic Diseases
Serum lactate dehydrogenase and alkaline phosphatase activities and serum cholesterol level in bone marrow blood.
Hemophilia A
Gamma-glutamyl transferase activity in the amniotic fluid of fetuses with chromosomal aberrations and inborn errors of metabolism.
Hepatic Encephalopathy
Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from patients with hepatic encephalopathy.
Changes in peripheral blood mononuclear cells glutamine synthetase mRNA after exercise in healthy volunteers: exploring an alternative proposal for non hepatic ammonia metabolism.
DNA synthesis in Alzheimer type II astrocytosis. The question of astrocytic proliferation and mitosis in experimentally induced hepatic encephalopathy.
Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy.
Effects of zinc deficiency/zinc supplementation on ammonia metabolism in patients with decompensated liver cirrhosis.
Hepatic encephalopathy: An update of pathophysiologic mechanisms.
Histamine-induced plasticity and gene expression in corticostriatal pathway under hyperammonemia.
Novel aspects of glutamine synthetase in ammonia homeostasis.
Pathophysiology of hepatic encephalopathy and future treatment options.
Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease.
Role of Exercise in the Management of Hepatic Encephalopathy: Experience From Animal and Human Studies.
Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo.
[Ammonia content and glutamine synthetase and glutaminase activity in the brain in experimental hepatic coma]
[Multivariate analysis of hepatic encephalopathy occurrence in patients with liver failure].
Hepatic Insufficiency
Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle.
Hepatitis
Double-blind, placebo-controlled pilot trial of anthocyanin-rich purple sweet potato beverage on serum hepatic biomarker levels in healthy Caucasians with borderline hepatitis.
Effect of Liver Damage and Hyperbaric Oxygenation on Glutamine Synthetase of Hepatocytes.
Elevated liver enzymes in Turner syndrome during a 5-year follow-up study.
Gamma-glutamyl transferase in the diagnosis of biliary atresia.
Gamma-glutamyl transferase: a novel cardiovascular risk biomarker.
HCFC-123-induced toxic hepatitis and death at a Korean fire extinguisher manufacturing facility: a case series.
Hepatic Involvement in Aicardi-Goutières Syndrome.
Hepatocellular carcinoma in a noncirrhotic patient with HIV: a case report and review of the literature.
Intake of purple sweet potato beverage affects on serum hepatic biomarker levels of healthy adult men with borderline hepatitis.
Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review.
Predictors of Increased Risk of Hepatocellular Carcinoma in Patients with Type 2 Diabetes.
Prevalence of hepatitis in early syphilis among an HIV cohort.
Relationships among viral diagnostic markers and markers of liver function in acute hepatitis E.
Serum alkaline-stable acid thiol proteinase--a possible marker for primary liver carcinoma.
Silymarin: a review of its clinical properties in the management of hepatic disorders.
Treatment of chronic liver disease with ursodeoxycholic acid.
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
Hepatitis A
Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism.
Hepatitis B
Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients.
Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad.
Effects of hepatitis B virus infection, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase on prediabetes and diabetes mellitus: A cohort study.
Efficacy and safety of YinQiSanHuang-antiviral decoction in chronic hepatitis B: study protocol for a randomized, placebo-controlled, double-blinded trial.
Exposure to mixtures of solvents among paint workers and biochemical alterations of liver function.
Immune and enzyme histochemical studies of a human hepatocellular carcinoma cell line producing hepatitis B surface antigen.
Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity: a population-based comparative epidemiological survey in Greenland and Denmark.
Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma.
Prognostic factors for survival in patients with compensated cirrhosis and small hepatocellular carcinoma after percutaneous ethanol injection therapy.
Prognostic factors of the short-term outcomes of patients with hepatitis B virus-associated acute-on-chronic liver failure.
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
Hepatitis B, Chronic
Abnormal liver function test results are related to metabolic syndrome and BMI in Taiwanese adults without chronic hepatitis B or C.
Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients.
Expression level of glutamine synthetase is increased in hepatocellular carcinoma and liver tissue with cirrhosis and chronic hepatitis B.
The gamma-glutamyl transferase to platelet ratio and the FIB-4 score are noninvasive markers to determine the severity of liver fibrosis in chronic hepatitis B infection.
The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
Total bile acid-to-cholesterol ratio as a novel noninvasive marker for significant liver fibrosis and cirrhosis in patients with non-cholestatic chronic hepatitis B virus infection.
Hepatitis C
Baseline gamma-glutamyl transferase levels strongly correlate with hepatocellular carcinoma development in non-cirrhotic patients with successful hepatitis C virus eradication.
Effects of ursodeoxycholic acid on serum liver enzymes in patients with hepatitis C virus-related chronic liver disease.
Gamma-glutamyl transferase (GGT) as an independent predictive factor of sustained virologic response in patients with hepatitis C treated with interferon-alpha and ribavirin.
Increased expression and phosphorylation of liver glutamine synthetase in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.
Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma.
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
[Hepatobiliary System Diseases as the Predictors of Psoriasis Progression].
[Prognostic significance of serum gamma-glutamyl transferase before transcatheter arterial chemoembolization in patients with hepatitis C virus-related hepatocellular carcinoma].
Hepatitis C, Chronic
Role of gamma-glutamyl transferase activity in patients with chronic hepatitis C virus infection.
Hepatitis, Alcoholic
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
Hepatitis, Autoimmune
Graft histology characteristics in long-term survivors of pediatric liver transplantation.
The Role of Genetic and Immune Factors for the Pathogenesis of Primary Sclerosing Cholangitis in Childhood.
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
Hepatitis, Chronic
Prognostic factors for survival in patients with compensated cirrhosis and small hepatocellular carcinoma after percutaneous ethanol injection therapy.
Treatment of chronic liver disease with ursodeoxycholic acid.
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
Hepatoblastoma
Complementary roles of ?-catenin and glutamine synthetase immunostaining in diagnosis of chemotherapy-treated and untreated hepatoblastoma.
Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma.
Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival.
Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells.
Proliferation and differentiation of a human hepatoblastoma transplanted in the Nude mouse.
The significant improvement of survival times and pathological parameters by bioartificial liver with recombinant HepG2 in porcine liver failure model.
Hepatomegaly
Clinical and laboratory signs of haemophagocytic lymphohistiocytosis associated with pandemic influenza A (H1N1) infection in patients needing extracorporeal membrane oxygenation: A retrospective observational study.
Liver AL amyloidosis as a possible cause of high liver stiffness values.
Tubulointerstitial nephropathy persisting 20 months after discontinuation of chronic intake of germanium lactate citrate.
Hip Dislocation
A novel mutation in VPS33B gene causing a milder ARC syndrome phenotype with prolonged survival.
Hirschsprung Disease
Immunocytochemical characterization of supporting cells in the enteric nervous system in Hirschsprung's disease.
HIV Infections
Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.
Glutamate metabolism in HIV-infected macrophages: implications for the CNS.
Huntington Disease
Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleus.
Glutamine Synthetase 1 Increases Autophagy Lysosomal Degradation of Mutant Huntingtin Aggregates in Neurons, Ameliorating Motility in a Drosophila Model for Huntington's Disease.
Glutamine synthetase activity in Huntington's disease.
Glutamine synthetase and fructose-1, 6-diphosphatase activity in the putamen of control and Huntington's disease brain post mortem.
Glutamine, glutamine synthetase and Huntington's disease.
Loss of glutamine synthetase activity in the brain in Huntington's disease.
Hydronephrosis
Risk of Renal Function Decline in Patients with Ketamine-Associated Uropathy.
Hyperglycemia
Probucol promotes high glucose-induced proliferation and inhibits apoptosis by reducing reactive oxygen species generation in Müller cells.
Hyperhomocysteinemia
Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic or glutamatergic pathways in hippocampus of rat dams and their offspring.
Mild Hyperhomocysteinemia Causes Anxiety-like Behavior and Brain Hyperactivity in Rodents: Are ATPase and Excitotoxicity by NMDA Receptor Overstimulation Involved in this Effect?
Hyperoxaluria
Renal peroxidative changes mediated by oxalate: the protective role of fucoidan.
Hypertension
Aging and hypertension decrease endothelial NO-related dilating function and gamma-glutamyl transferase activity but not S-nitrosoglutathione-induced aortic vasodilation.
Association between FTO (rs17817449) genetic variant, gamma-glutamyl transferase, and hypertension in Slovak midlife women.
Association Between Serum Gamma-glutamyl Transferase Level and Hypertension in Indian Adults: A Population Based Cross-Sectional Study.
Association between serum gamma-glutamyl transferase level and prehypertension among community-dwelling men.
Chronic fatigue syndrome and related disorders in UK veterans of the Gulf War 1990-1991: results from a two-phase cohort study.
CONKO-006: A randomised double-blinded phase IIb-study of additive therapy with gemcitabine + sorafenib/placebo in patients with R1 resection of pancreatic cancer - Final results.
Gamma-glutamyl transferase activity as a predictive marker for severity of obstructive sleep apnea syndrome and concomitant hypertension.
Gamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese.
Glutamine synthetase activity and glutamate uptake in hippocampus and frontal cortex in portal hypertensive rats.
Glutathione-related antioxidant defense system in patients with hypertensive retinopathy.
Obesity, albuminuria, and gamma-glutamyl transferase predict incidence of hypertension in indigenous Australians in rural and remote communities in northern Australia.
Phase I trial of sorafenib following liver transplantation in patients with high-risk hepatocellular carcinoma.
Prevalence and predictors of non-alcoholic steatohepatitis in patients with morbid obesity.
Serum Gamma-Glutamyl Transferase (GGT) Levels and Inflammatory Activity in Patients with Non-Dipper Hypertension.
Serum gamma-glutamyl transferase level in predicting hypertension among male drinkers.
Serum gamma-glutamyl transferase level is an independent predictor of incident hypertension in korean adults.
The effect of resveratrol on hypertension: A clinical trial.
The relationship between gamma-glutamyl transferase levels and chronic kidney disease among Appalachian adults.
Vital capacity and selected metabolic diseases in middle-aged Japanese men.
[Association between hematocrit and risk of incident hypertension: a cohort study].
Hypertension, Portal
Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression.
Characteristics of Liver Disease in 100 Individuals With Joubert Syndrome Prospectively Evaluated at a Single Center.
Focal nodular hyperplasia-like lesion of the liver with focal adenoma features associated with idiopathic portal hypertension.
Nodular Regenerative Hyperplasia of the Liver: A Rare Vascular Complication in Systemic Sclerosis.
Hypertension, Pregnancy-Induced
Gamma-glutamyl transferase activity in gestational hypertension.
Hypertensive Retinopathy
Glutathione-related antioxidant defense system in patients with hypertensive retinopathy.
The Association of Oxidative Stress with Hypertensive Retinopathy.
Hyperthyroidism
Oxidative stress induced by thyroid dysfunction in rat erythrocytes and heart.
Plasma 25-hydroxyvitamin D and alkaline phosphatase isoenzymes in hyperthyroidism.
Hypertriglyceridemia
Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort.
Vital capacity and selected metabolic diseases in middle-aged Japanese men.
Hyperventilation
Sensitivity of ventilation and brain metabolism to ammonia exposure in rainbow trout, Oncorhynchus mykiss.
Hypoalbuminemia
Coronavirus disease (COVID-19) and the liver: a comprehensive systematic review and meta-analysis.
Hypoglycemia
Hypoglycemia induces general neuronal death, whereas hypoxia and glutamate transport blockade lead to selective retinal ganglion cell death in vitro.
Hypokalemia
Expression of glutamine synthetase in the mouse kidney: localization in multiple epithelial cell types and differential regulation by hypokalemia.
The Mechanism of Valproic Acid-Induced Fanconi Syndrome Involves Mitochondrial Dysfunction and Oxidative Stress in Rat Kidney.
Hypokinesia
[The effect of prolonged antiorthostatic hypokinesia on the blood serum activity of enzymes involved in energy and plastic metabolism]
Hypophosphatemia
Phase 1 Open-Label, Multicenter Study of First-in-Class ROR? Agonist LYC-55716 (Cintirorgon): Safety, Tolerability, and Preliminary Evidence of Antitumor Activity.
The Mechanism of Valproic Acid-Induced Fanconi Syndrome Involves Mitochondrial Dysfunction and Oxidative Stress in Rat Kidney.
Hypothyroidism
Hypothyroidism is a Predictive Factor of Superior Anti-tumor Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma.
Infarction, Middle Cerebral Artery
Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration.
Infections
1-Hydroxyanthraquinone exhibited antibacterial activity by regulating glutamine synthetase of Staphylococcus xylosus as a virulence factor.
Active equine parvovirus-hepatitis infection is most frequently detected in Austrian horses of advanced age.
Alterations in polymeric immunoglobulin receptor expression and secretory component levels in bladder carcinoma.
Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients.
Case Report: Viral Pneumonia Could Prompt the Advancement of Immune-Mediated Liver Disease.
Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis.
Characteristics of nondisabled older persons who perform poorly in objective tests of lower extremity function.
Contribution of glutamine synthetase to the virulence of Streptococcus suis serotype 2.
Deletion of Glutamine Synthetase Gene Disrupts the Survivability and Infectivity of Leishmania donovani.
Effects of Epstein-Barr virus infection on liver function in children.
Ehrlichia chaffeensis proliferation begins with NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and glutamine uptake.
Expression and efficient export of enzymatically active Mycobacterium tuberculosis glutamine synthetase in Mycobacterium smegmatis and evidence that the information for export is contained within the protein.
Expression of glutamine synthetase genes in roots and nodules of Phaseolus vulgaris following changes in the ammonium supply and infection with various Rhizobium mutants.
Intrahepatic Cholestasis Is a Clinically Significant Feature Associated with Natural History of X-Linked Myotubular Myopathy (XLMTM): A Case Series and Biopsy Report.
Lactobacillus crispatus and its enolase and glutamine synthetase influence interactions between Neisseria gonorrhoeae and human epithelial cells.
Metabolic and proteomic analysis of nitrogen metabolism mechanisms involved in the sugarcane - Fusarium verticillioides interaction.
Novel association of Streptococcus gallolyticus subspecies pasteurianus and hepatocelluar carcinoma: opening new frontiers.
Postoperative Adjuvant Transarterial Chemoembolization Improves Short-Term Prognosis of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus: A Propensity-Score Matching Study.
Preliminary crystallographic studies on glutamine synthetase from Mycobacterium tuberculosis.
Prenatal treatment of congenital human cytomegalovirus infection by fetal intravascular administration of ganciclovir.
Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection?
Regulation of Nodule Glutamine Synthetase by CO(2) Levels in Bean (Phaseolus vulgaris L.).
Relationship Between COVID-19 Infection and Liver Injury: A Review of Recent Data.
Role of gamma-glutamyl transferase activity in patients with chronic hepatitis C virus infection.
Serum enzyme tests in hepatosplenic schistosomiasis.
The fate of glutamate in different brain regions of the chick during Newcastle disease virus infection.
The gamma-glutamyl transferase to platelet ratio and the FIB-4 score are noninvasive markers to determine the severity of liver fibrosis in chronic hepatitis B infection.
The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection.
Value of liver biopsy for the rapid diagnosis of infection in human immunodeficiency virus-infected patients who have unexplained fever and elevated serum levels of alkaline phosphatase or gamma-glutamyl transferase.
[Changes in blood bilirubin and plasma activity of gamma-glutamyl transferase in lambs experimentally infested with Fasciola hepatica]
[Multivariate analysis of hepatic encephalopathy occurrence in patients with liver failure].
Infertility
[Role of spermatic plasma enzyme in pathogenesis of relative male sterility]
Infertility, Female
Cloning and characterization of a copy of Tirant transposable element in Drosophila melanogaster.
Mutations in the glutamine synthetase I (gsI) gene produce embryo-lethal female sterility in Drosophila melanogaster.
Infertility, Male
Combination of reversible male sterility and doubled haploid production by targeted inactivation of cytoplasmic glutamine synthetase in developing anthers and pollen.
Reversible male sterility in transgenic tobacco carrying a dominant-negative mutated glutamine synthetase gene under the control of microspore-specific promoter.
Inflammatory Bowel Diseases
Incidence, risk factors and clinical course of thiopurine-induced liver injury in patients with inflammatory bowel disease.
Influenza, Human
Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism.
Insulin Resistance
A Preliminary Study on the Effect of Psyllium Husk Ethanolic Extract on Hyperlipidemia, Hyperglycemia, and Oxidative Stress Induced by Triton X-100 Injection in Rats.
A significant decline in IGF-I may predispose young Africans to subsequent cardiometabolic vulnerability.
Association between Healthy Eating Index-2010 and Fetuin-A Levels in Patients with Type 2 Diabetes: a Case-Control Study.
Associations between weight change and biomarkers of cardiometabolic risk in South Asians: secondary analyses of the PODOSA trial.
Eating meals irregularly: a novel environmental risk factor for the metabolic syndrome.
Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease.
Factors determining the serum 25-hydroxyvitamin D response to vitamin D supplementation: Data mining approach.
Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011.
Low levels of Lysosomal Acid Lipase (LAL) activity increases necroinflammation in adult patients with biopsy-proven metabolic associated fatty liver disease.
Metabolic and hepatic effects of bloodletting in dysmetabolic iron overload syndrome: A randomized controlled study in 274 patients.
Multicomponent Exercise Training Combined with Nutritional Counselling Improves Physical Function, Biochemical and Anthropometric Profiles in Obese Children: A Pilot Study.
Multifocal fatty liver disease, insulin resistance and carotid atherosclerosis: exploring the interrelated relationship.
Multiple biomarkers and their relative contributions to identifying metabolic syndrome.
Prevalence and predictors of non-alcoholic steatohepatitis in patients with morbid obesity.
Redox Proteomics: A Key Tool for New Insights into Protein Modification with Relevance to Disease.
Relationship of liver enzymes to insulin sensitivity and intra-abdominal fat.
Role of gamma-glutamyl transferase (GGT) in diagnosis of impaired glucose tolerance and metabolic syndrome: a prospective cohort research from the Kerman Coronary Artery Disease Risk Study (KERCADRS).
Salidroside and Curcumin Formula Prevents Liver Injury in Nonalcoholic Fatty Liver Disease in Rats.
Sodium acetate prevents nicotine-induced cardiorenal dysmetabolism through uric acid/creatine kinase-dependent pathway.
Intestinal Diseases
Glutamine supplementation and deprivation: effect on artificially reared rat small intestinal morphology.
Iron Overload
Protective effect of grape seed and skin extract on cerebral ischemia in rat: implication of transition metals.
Irritable Bowel Syndrome
Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model.
Ischemic Stroke
Association between Serum Gamma-glutamyl transferase and Intracranial Arterial Calcification in Acute Ischemic Stroke Subjects.
Gamma-glutamyl transferase levels in patients with acute ischemic stroke.
Increased concentration of serum gamma-glutamyl transferase in ischemic stroke patients.
Keloid
Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue.
Ketosis
Glucose and insulin responses to glucagon injection in dairy cows with ketosis and fatty liver.
Hepatic lipidosis in anorectic, lactating holstein cattle: a retrospective study of serum biochemical abnormalities.
Kidney Failure, Chronic
Serum gamma-glutamyl transferase activity in chronic renal failure during regular hemodialysis and after successful renal transplantation.
Leishmaniasis
Urinary gamma-glutamyl transferase (GGT) as a marker of tubular proteinuria in dogs with canine leishmaniasis, using sodium dodecylsulphate (SDS) electrophoresis as a reference method.
Leukemia
Histochemical quantitation of gamma-glutamyl transferase in human leukemia cell lines.
Leukemia Cells Resistant to Glutamine Deprivation Express Glutamine Synthetase (GS) Protein.
Rewired metabolism in drug-resistant leukemia cells: A metabolic switch hallmarked by reduced dependence on exogenous glutamine.
Leukocytosis
Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees.
Hepatic Cyst: An Unusual Suspect of Syncope.
Retrospective analysis of cases with an ectopic opening of the common bile duct into duodenal bulb.
Leukopenia
Phase I trial of sorafenib following liver transplantation in patients with high-risk hepatocellular carcinoma.
Lipodystrophy
Evaluation of a 6-Year Highly Active Antiretroviral Therapy in Chinese HIV-1-Infected Patients.
Liver Cirrhosis
A preliminary trial of high-dose ursodeoxycholic acid in primary sclerosing cholangitis.
A stepwise algorithm using an at-a-glance first-line test for the non-invasive diagnosis of advanced liver fibrosis and cirrhosis.
Computed Tomography-Measured Liver Volume Predicts the Risk of Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients.
Effect of WeiJia on carbon tetrachloride induced chronic liver injury.
Effects of carnosine on bilharzial infestation in hamsters: biochemical and histochemical studies.
Low levels of Lysosomal Acid Lipase (LAL) activity increases necroinflammation in adult patients with biopsy-proven metabolic associated fatty liver disease.
Pericentral hepatocytes produce IGF-2 to promote liver regeneration during special injuries.
Predictors of sustained virological response in patients with hepatitis C virus genotype 3 infection.
Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats.
Risk factors of silent allograft fibrosis 10 years post-pediatric liver transplantation.
Serum alkaline-stable acid thiol proteinase--a possible marker for primary liver carcinoma.
The gamma-glutamyl transferase to platelet ratio and the FIB-4 score are noninvasive markers to determine the severity of liver fibrosis in chronic hepatitis B infection.
Total bile acid-to-cholesterol ratio as a novel noninvasive marker for significant liver fibrosis and cirrhosis in patients with non-cholestatic chronic hepatitis B virus infection.
[Analysis of clinical features and prognosis in patients with primary Sjögren's syndrome and autoimmune liver disease].
[Gamma-glutamyltransferase and alkaline phosphatase in the serum and saliva of patients with hepatic tumors and hepatic cirrhosis]
[Multivariate analysis of hepatic encephalopathy occurrence in patients with liver failure].
Liver Cirrhosis, Alcoholic
Predictors of Increased Risk of Hepatocellular Carcinoma in Patients with Type 2 Diabetes.
Total serum bile acids, gamma-glutamyl transferase, prealbumin, and tyrosine: sensitive serum markers of hepatic dysfunction in alcoholic liver cirrhosis.
Liver Cirrhosis, Biliary
Treatment of chronic liver disease with ursodeoxycholic acid.
[Treatment of cholestatic liver disease]
Liver Diseases
Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through activation of the Wnt/?-catenin signaling pathway.
Assessment of the plasma disappearance of cholyl'l14C-glycine as a test of hepatocellular disease.
Astrocyte glutamine synthetase: importance in hyperammonemic syndromes and potential target for therapy.
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease.
Diagnostic value of serum gamma-glutamyl transferase and alkaline phosphatase activities in hepatobiliary disease in the cat.
Effects of ursodeoxycholic acid on serum liver enzymes in patients with hepatitis C virus-related chronic liver disease.
Estimation of gamma-glutamyl transferase as a suitable simple biomarker of the cardiovascular risk in children with non-alcoholic fatty liver disease.
Evaluation of biochemical profile of Chronic Kidney Disease of uncertain etiology in Sri Lanka.
Evaluation of tumour necrosis factor-alpha, soluble P-selectin, gamma-glutamyl transferase, glutathione S-transferase-pi and alpha-fetoprotein in patients with hepatocellular carcinoma before and during chemotherapy.
Field study of dairy cows with reduced appetite in early lactation: clinical examinations, blood and rumen fluid analyses.
Gamma glutamyl transferase.
Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease: The Gut and Obesity Asia initiative.
Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011.
Gamma-glutamyl transferase: a novel cardiovascular risk biomarker.
Hepatic gamma-glutamyl transferase and hepatic fibrosis in patients with alcoholic liver disease.
Hepatic lipidosis in anorectic, lactating holstein cattle: a retrospective study of serum biochemical abnormalities.
Hepatitis during chloroguanide prophylaxis.
Hepatoprotective and immunomodulatory effects of copper-nicotinate complex against fatty liver in rat model.
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
Metabolic risk factors, genetic predisposition, and risk of severe liver disease in Chinese: a prospective study of 0.5 million people.
Multifocal fatty liver disease, insulin resistance and carotid atherosclerosis: exploring the interrelated relationship.
Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.
Non-Alcoholic Fatty Liver Disease Modifies Serum Gamma-Glutamyl Transferase in Cigarette Smokers.
Persistent elevation of liver function enzymes within the reference range is associated with increased cardiovascular risk in young adults: the Bogalusa Heart Study.
Protein Tyrosine Phosphatase Nonreceptor Type 2 Expression Does Not Correlate with Viral Load or Response to Direct-Acting Antiviral Therapy in Hepatitis C Virus Infections-Infected Patients.
Relationship of liver enzymes to insulin sensitivity and intra-abdominal fat.
Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease.
Role of betaine in liver injury induced by the exposure to ionizing radiation.
Serum gamma-glutamyl transferase in liver disease among the Igbos of Eastern Nigeria.
Serum levels of gamma-glutamyl transferase are associated with markers of nocturnal hypoxemia in a general adult population.
Significance of gamma-glutamyl transferase (GGT) activity measurements in alcohol-induced hepatic injury.
Silymarin: a review of its clinical properties in the management of hepatic disorders.
The effect of thioacetamide on urea cycle enzymes of rat liver.
The gamma-glutamyltransferase/glutamine synthetase activity ratio. A powerful marker for the acinar origin of hepatocytes.
The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease.
Trace and non-trace elements in blood cells of bottlenose dolphins (Tursiops truncatus): variations with values from liver function indicators.
Transport of neutral amino acids at the blood-brain barrier.
Tubulointerstitial nephropathy persisting 20 months after discontinuation of chronic intake of germanium lactate citrate.
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
Use of gamma-glutamyl transferase as a screen for liver disease in muscular dystrophy patients.
Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement.
[Association of gamma glutamyltransferase, metabolic syndrome and cardiovascular risk]
[Treatment of cholestatic liver disease]
[Value of serum levels of conjugated cholic acid in the diagnosis of liver disease (author's transl)]
[[LIVER TOXICITY DUE TO RIFAMPICIN MONOTHERAPY IN LATENT TUBERCULOSIS INFECTION].]
Liver Diseases, Alcoholic
Biomarkers of alcohol consumption in patients classified according to the degree of liver disease severity.
Hepatic gamma-glutamyl transferase and hepatic fibrosis in patients with alcoholic liver disease.
IgA against gut-derived endotoxins: does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease?
Liver giant mitochondria revisited.
Liver Failure
In vitro suppression of inflammatory cytokine response by methionine sulfoximine.
In vivo estimation of bioartificial liver with recombinant HepG2 cells using pigs with ischemic liver failure.
Ornithine phenylacetate targets alterations in the expression and activity of glutamine synthase and glutaminase to reduce ammonia levels in bile duct ligated rats.
Pathogenesis of hepatic encephalopathy in cirrhosis: the concept of synergism revisited.
Pathophysiology of brain dysfunction in hyperammonemic syndromes: The many faces of glutamine.
Prolongation of survival of pigs with ischemic liver failure by treatment with a bioartificial liver using glutamine synthetase transfected recombinant HepG2.
Protective Effect of Opuntia dillenii (Ker Gawl.) Haw. Seed Oil on Gentamicin-Induced Nephrotoxicity: A Biochemical and Histological Analysis.
The significant improvement of survival times and pathological parameters by bioartificial liver with recombinant HepG2 in porcine liver failure model.
Liver Failure, Acute
A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure.
Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure.
Liver Neoplasms
Overexpression of glutamine synthetase in human primary liver cancer.
Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark.
Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma.
[Clinical application of avidin-biotin ELISA to detect serum hepatoma-specific gamma-glutamyltransferase in patients with primary hepatic cancer]
Lung Injury
Hyperoxia-Induced Lung Injury in Gamma-Glutamyl Transferase Deficiency Is Associated with Alterations in Nitrosative and Nitrative Stress.
Lung Neoplasms
Alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase and creatine kinase in bronchial aspirate from neoplastic and normal pulmonary tissue.
Demonstration of gamma-glutamyl transferase, alkaline phosphatase, CEA and HCG in human lung cancer.
IS GAMMA-GLUTAMYL TRANSFERASE A PROGNOSTIC INDICATOR FOR EARLY-STAGE LUNG CANCER TREATED SURGICALLY?
Prognostic significance of gamma-glutamyl transferase in patients with metastatic non-small cell lung cancer.
Rhophilin-2 Upregulates Glutamine Synthetase by Stabilizing c-Myc Protein and Confers Resistance to Glutamine Deprivation in Lung Cancer.
TRAP1 Inhibition Increases Glutamine Synthetase Activity in Glutamine Auxotrophic Non-small Cell Lung Cancer Cells.
Lupus Erythematosus, Systemic
Association Between Gamma-Glutamyl Transferase, Total Bilirubin and Systemic Lupus Erythematosus in Chinese Women.
Lymphadenopathy
Clinical differentiation of infectious mononucleosis that is caused by Epstein-Barr virus or cytomegalovirus: A single-center case-control study in Japan.
Lymphatic Metastasis
Peritumoral plasmacytoid dendritic cells predict a poor prognosis for intrahepatic cholangiocarcinoma after curative resection.
Lymphocytosis
Clinical differentiation of infectious mononucleosis that is caused by Epstein-Barr virus or cytomegalovirus: A single-center case-control study in Japan.
Novel association of Streptococcus gallolyticus subspecies pasteurianus and hepatocelluar carcinoma: opening new frontiers.
Lymphohistiocytosis, Hemophagocytic
Oral features of Griscelli syndrome type II: A rare case report.
Lymphoma
Alkaline phosphatase in hematopoietic tumor cell lines of the mouse: high activity in cells of the B lymphoid lineage.
Alterations in total iron, zinc, and calcium levels and their influence on the hepatic activities of gamma-glutamyl transferase and glucose-6-phosphatase in the host bearing transplantable murine lymphoma.
Malformations of Cortical Development
Expression of glutamine synthetase in balloon cells: a basis of their antiepileptic role?
Glutamate clearance mechanisms in resected cortical dysplasia.
Malnutrition
Clinical-nutritional, inflammatory and oxidative stress predictors in hemodialysis mortality: a review.
Serum aminotransferases and gamma-glutamyl transferase in protein energy malnutrition.
Melanoma
Human melanoma cells generate leukotrienes B4 and C4 from leukotriene A4.
Membrane gamma-glutamyl transferase activity promotes iron-dependent oxidative DNA damage in melanoma cells.
Prognostic role of gamma-glutamyl transferase in metastatic melanoma patients treated with immune checkpoint inhibitors.
Memory Disorders
The effect of glial glutamine synthetase inhibition on recognition and temporal memories in the rat.
Meningioma
Barrier functions of the leptomeninges: a study of normal meninges and meningiomas in tissue culture.
Meningitis
Glutamine synthetase in experimental meningitis: increased ratio of the subunits 3 and 2 may indicate enhanced activity.
Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus.
Meningitis, Bacterial
Regional differences in glutamine synthetase inhibition by L-methionine sulfoximine: a microdialysis study in the rabbit brain.
Meningitis, Pneumococcal
Glutamine synthetase in experimental meningitis: increased ratio of the subunits 3 and 2 may indicate enhanced activity.
Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis.
Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus.
Metabolic Diseases
Vital capacity and selected metabolic diseases in middle-aged Japanese men.
Metabolic Syndrome
Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis.
Association of Serum Gamma-Glutamyl Transferase and Ferritin with the Metabolic Syndrome.
Eating meals irregularly: a novel environmental risk factor for the metabolic syndrome.
Elevated Liver Enzymes in Metabolic Syndrome Are Associated With Coronary Stenosis in a Tunisian Population.
Gamma-glutamyl transferase: another biomarker for metabolic syndrome and cardiovascular risk.
Hemostatic risk factors and insulin sensitivity, regional body fat distribution, and the metabolic syndrome.
High-normal blood pressure is associated with a cluster of cardiovascular and metabolic risk factors: a population-based study.
High-sensitivity C-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons.
Independent and supra-additive effects of alcohol consumption, cigarette smoking, and metabolic syndrome on the elevation of serum liver enzyme levels.
Insulin Resistance but Not Visceral Adiposity Index Is Associated with Liver Fibrosis in Nondiabetic Subjects with Nonalcoholic Fatty Liver Disease.
Irritable Bowel Syndrome May Be Associated with Elevated Alanine Aminotransferase and Metabolic Syndrome.
Perirenal Fat and Association With Metabolic Risk Factors: The Uberlândia Heart Study.
Persistent elevation of liver function enzymes within the reference range is associated with increased cardiovascular risk in young adults: the Bogalusa Heart Study.
Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.
Role of gamma-glutamyl transferase (GGT) in diagnosis of impaired glucose tolerance and metabolic syndrome: a prospective cohort research from the Kerman Coronary Artery Disease Risk Study (KERCADRS).
Serum gamma-glutamyl transferase activity predicts future development of metabolic syndrome defined by 2 different criteria.
Serum gamma-glutamyl transferase levels are associated with metabolic syndrome in community-dwelling individuals.
The Association between Metabolic Syndrome and Related Factors among the Community-Dwelling Indigenous Population in Taiwan.
The association of higher levels of within-normal-limits liver enzymes and the prevalence of the metabolic syndrome.
[Association of gamma-glutamyl transferase and the metabolic syndrome in obese women]
Metabolism, Inborn Errors
Gamma-glutamyl transferase activity in the amniotic fluid of fetuses with chromosomal aberrations and inborn errors of metabolism.
Microcephaly
[Prenatal symptoms and diagnosis of inherited metabolic diseases].
Microvascular Angina
Elevated serum gamma-glutamyl transferase activity in patients with cardiac syndrome X and its relationship with carotid intima media thickness.
Mouth Neoplasms
c-Myc Overexpression Promotes Oral Cancer Cell Proliferation and Migration by Enhancing Glutaminase and Glutamine Synthetase Activity.
Mucositis
Population pharmacokinetics of posaconazole in neutropenic patients receiving chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome.
Multiple Sclerosis
CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD.
The activity of gamma-glutamyl transferase in the serum of multiple sclerosis and other neurological diseases.
Muscle Hypotonia
A Very Rare Etiology of Hypotonia and Seizures: Congenital Glutamine Synthetase Deficiency.
Muscle Weakness
Corticosteroid effects in skeletal muscle: gene induction/receptor autoregulation.
Muscular Atrophy
Alanyl-glutamine prevents muscle atrophy and glutamine synthetase induction by glucocorticoids.
Exercise interrupts ongoing glucocorticoid-induced muscle atrophy and glutamine synthetase induction.
Glucocorticoid-mediated induction of glutamine synthetase in skeletal muscle.
Lack of contribution of 11betaHSD1 and glucocorticoid action to reduced muscle mass associated with reduced growth hormone action.
Muscular Diseases
Insulin-like growth factor 1 inhibits glucocorticoid-induced glutamine synthetase activity in cultured L6 rat skeletal muscle cells.
Steroid myopathy: pathogenesis and effects of growth hormone and insulin-like growth factor-I administration.
Muscular Dystrophies
Use of gamma-glutamyl transferase as a screen for liver disease in muscular dystrophy patients.
Myalgia
Underlying mechanisms of phosphodiesterase 10A and glutamate-ammonia ligase genes that regulate inosine monophosphate deposition and thereby affect muscle tenderness in Jingyuan chickens.
Mycoses
Improvement of nitrogen accumulation and metabolism in rice (Oryza sativa L.) by the endophyte Phomopsis liquidambari.
Myocardial Infarction
Effect of serum gamma-glutamyl transferase levels on myocardial perfusion and long-term prognosis after primary angioplasty in patients with acute ST-elevation myocardial infarction.
Predictive Value of Gamma-Glutamyl Transferase Levels for Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention.
Prognostic value of serum gamma-glutamyl transferase activity after myocardial infarction.
Serum Gamma-Glutamyl Transferase Activity as a Potential Novel Cardiovascular Biomarker in COPD.
Serum gamma-glutamyl transferase is a predictor of mortality in patients with acute myocardial infarction.
Myocardial Ischemia
Serum gamma-glutamyl transferase is a predictor of mortality in patients with acute myocardial infarction.
Nasopharyngitis
A multicenter, phase 2 study to evaluate the efficacy and safety of osilodrostat, a new 11?-hydroxylase inhibitor, in Japanese patients with endogenous Cushing's syndrome other than Cushing's disease.
Neoplasm Metastasis
Lactate Dehydrogenase Prior to Transarterial Hepatic Chemoperfusion Predicts Survival and Time to Progression in Patients with Uveal Melanoma Liver Metastases.
Locoregional therapy and systemic cetuximab to treat colorectal liver metastases.
Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.
Prognostic nomogram for predicting 5-year overall survival in Chinese patients with high-grade osteosarcoma.
Serum gamma glutamyl-transferase is a sensitive but unspecific marker of metastatic renal cell carcinoma.
Stauffer's syndrome variant with cholestatic jaundice: a case report.
Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.
Value of serum-5-nucleotidase, alkaline phosphatase and gamma-glutamyl transferase for prediction of liver metastases preoperatively in colorectal cancer.
[Biochemical parameters in the comprehensive diagnosis of lung cancer]
Neoplasms
?-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice.
?-glutamyl transferase-to-platelet ratio based nomogram predicting overall survival of gallbladder carcinoma.
A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors.
A case of progressing focal nodular hyperplasia and its molecular expression pattern.
A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor.
A study of glutamine synthetase in normal human brain and intracranial tumours.
Ability of a biomarker-based score to predict death from circulatory disease and cancer in NHANES III.
Alterations in total iron, zinc, and calcium levels and their influence on the hepatic activities of gamma-glutamyl transferase and glucose-6-phosphatase in the host bearing transplantable murine lymphoma.
Ameliorative effect of septilin, an ayurvedic preparation against gamma-irradiation-induced oxidative stress and tissue injury in rats.
An Adult Case of Congenital Extrahepatic Portosystemic Shunt Successfully Treated with Balloon-occluded Retrograde Transvenous Obliteration.
Analysis of glucocorticoid-inducible genes in wild-type and variant rat hepatoma cells.
Aspects of glutamine metabolism in human tumour cells.
Astrocytes Regulate Differentiation and Glutamate Uptake of Glioma Stem Cells via Formyl Peptide Receptor.
Atypical hepatocellular adenoma-like neoplasms with ?-catenin activation show cytogenetic alterations similar to well-differentiated hepatocellular carcinomas.
Beta-catenin-activated hepatocellular adenoma in a male.
Biodegradable Poly(?-glutamic acid)@glucose oxidase@carbon dot nanoparticles for simultaneous multimodal imaging and synergetic cancer therapy.
c-Myc Overexpression Promotes Oral Cancer Cell Proliferation and Migration by Enhancing Glutaminase and Glutamine Synthetase Activity.
Changes in blood biochemical markers before, during, and after a 2-day ultramarathon.
Changes in mRNAs for enzymes of glutamine metabolism in the tumor-bearing mouse.
Cholinergic neurons of fetal rat telencephalon in aggregating cell culture respond to NGF as well as to protein kinase C-activating tumor promoters.
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma.
Contribution by host tissues to circulating glutamine in mice inoculated with Ehrlich ascites tumor cells.
Correlation of exon 3 ?-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma.
CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice.
Deficiency of the promyelocytic leukemia protein fosters hepatitis C-associated hepatocarcinogenesis in mice.
Development of Hepatocellular Carcinoma in a Murine Model of Nonalcoholic Steatohepatitis Induced by Use of a High-Fat/Fructose Diet and Sedentary Lifestyle.
Diagnostic Value of Glypican3, Heat Shock Protein 70 and Glutamine Synthetase in Hepatocellular Carcinoma Arising in Cirrhotic and Non-Cirrhotic Livers.
Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis.
Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma.
Differential regulation of proenkephalin expression in astrocytes by cytokines.
Diffuse glutamine synthetase overexpression restricted to areas of peliosis in a ?-catenin-activated hepatocellular adenoma: a potential pitfall in glutamine synthetase interpretation.
Dysregulation of glutaminase and glutamine synthetase in cancer.
Early diagnosis of breast cancer dissemination by tumor markers follow-up and method of prediction.
Early recurrence after radiofrequency ablation for hepatocellular carcinoma: a multicenter retrospective study on definition, patterns and risk factors.
Effect of a rhodium complex on alterations of hepatic function in thioacetamide-induced hyperplastic noduligenesis in rats.
Evaluation of HCPTd1,d14-double passaged intervening chemotherapy protocol for hepatocellular carcinoma.
Evaluation of salivary gamma-glutamyl transpeptidase as a biomarker in oral squamous cell carcinoma and precancerous lesions.
Evaluation of tumour necrosis factor-alpha, soluble P-selectin, gamma-glutamyl transferase, glutathione S-transferase-pi and alpha-fetoprotein in patients with hepatocellular carcinoma before and during chemotherapy.
Expression analysis of tumour necrosis factor alpha (TNF-?) and alkaline phosphatase in occupational workers exposed to low dose of X-radiation: A case-control study.
gamma-Glutamyl transferase and breast cancer risk.
Gamma-glutamyl transferase: risk and prognosis of cancer.
Gene Expression and Mutation Assessment Provide Clues of Genetic and Epigenetic Mechanisms in Liver Tumors of Oxazepam-Exposed Mice.
Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum.
Germline and somatic DICER1 mutations in familial and sporadic liver tumors.
Global profiling of the signaling network of papillary thyroid carcinoma.
Glucose, lipids and gamma-glutamyl transferase measured before prostate cancer diagnosis and secondly diagnosed primary tumours: a prospective study in the Swedish AMORIS cohort.
Glutamine metabolism in the avian host bearing transplantable hepatomatous growth induced by MC-29 virus.
Glutamine metabolism in the proliferation of GS-expression pituitary tumor cells.
Glutamine metabolism links growth factor signaling to the regulation of autophagy.
Glutamine synthetase and glutaminase activities in various hepatoma cells.
Glutamine Synthetase as a Therapeutic Target for Cancer Treatment.
Glutamine synthetase facilitates cancer cells to recover from irradiation-induced G2/M arrest.
Glutamine synthetase in the host tissues of tumour bearing mice.
Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.
Glutamine synthetase promotes tumor invasion in hepatocellular carcinoma through mediating epithelial-mesenchymal transition.
Glutamine Synthetase, Heat shock Protein-70, and Glypican-3 in Intrahepatic Cholangiocarcinoma and Tumors Metastatic to Liver.
Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?
Growth in culture and tumorigenicity after transfection with the ras oncogene of liver epithelial cells from carcinogen-treated rats.
Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats.
Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met.
Hepatocellular adenoma in a woman who was undergoing testosterone treatment for gender identity disorder.
Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor.
Hepatocellular Carcinoma Arising in an HNF-1?-Mutated Adenoma in a 23-Year-Old Woman with Maturity-Onset Diabetes of the Young: A Case Report.
Hepatocellular Neoplasms Arising in Association With Androgen Use.
Hepatocellular tumors: immunohistochemical analyses for classification and prognostication.
Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis.
Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice.
High Levels of Gamma-Glutamyl Transferase and Indocyanine Green Retention Rate at 15?min as Preoperative Predictors of Tumor Recurrence in Patients With Hepatocellular Carcinoma.
Histopathological and biochemical analyses of transplantable renal adenocarcinoma in rats induced by N-ethyl-N-hydroxyethylnitrosamine.
Histopathological characteristics of glutamine synthetase-positive hepatic tumor lesions in a mouse model of spontaneous metabolic syndrome (TSOD mouse).
Homeopathic drugs Natrum sulphuricum and Carcinosin prevent azo dye-induced hepatocarcinogenesis in mice.
Hypoxia-inducible factor-1? promotes cell survival during ammonia stress response in ovarian cancer stem-like cells.
Immune and enzyme histochemical studies of a human hepatocellular carcinoma cell line producing hepatitis B surface antigen.
Immunoexpression of Heat Shock Protein 70, Glypican 3, Glutamine Synthetase, and Beta-Catenin in Hepatocellular Carcinoma After Liver Transplantation: Association Between Positive Glypican 3 and Beta-Catenin With the Presence of Larger Nodules.
Immunohistochemical characteristics of hepatocellular carcinoma in non-cirrhotic livers.
Immunohistochemical Characterization of Spontaneous and Acrylonitrile-induced Brain Tumors in the Rat.
Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas.
In vitro aberrant gene expression as the indicator of lead-induced neurotoxicity in U-373MG cells.
Induction of Chronic Subclinical Systemic Inflammation in Sprague-Dawley Rats Stimulated by Intermittent Bolus Injection of Lipopolysaccharide.
Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappaB in mice.
Inhibitors of glutamine synthetase and their potential application in medicine.
Inhibitory Effect of Nelumbo nucifera Leaf Extract on 2-Acetylaminofluorene-induced Hepatocarcinogenesis Through Enhancing Antioxidative Potential and Alleviating Inflammation in Rats.
Interleukin-1 beta and tumor necrosis factor-alpha suppress dexamethasone induction of glutamine synthetase in primary mouse astrocytes.
Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats.
Key Transport and Ammonia Recycling Genes Involved in Aphid Symbiosis Respond to Host-Plant Specialization.
Lactate Dehydrogenase Prior to Transarterial Hepatic Chemoperfusion Predicts Survival and Time to Progression in Patients with Uveal Melanoma Liver Metastases.
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
Malignant transformation of a ?-catenin inflammatory adenoma due to an S45 ?-catenin-activating mutation present 12 years before.
Methionine sulfoximine intensifies cancer anorexia.
Mitochondrial glutathione depletion by glutamine in growing tumor cells.
Modeling a Human HCC Subset in Mice Through Co-Expression of Met and Point-Mutant ?-Catenin.
Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet.
Nomogram for Individualized Prediction of Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis on Conservative Treatment.
Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth.
Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation.
Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology.
Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.
Overexpression of human beta TrCP1 deleted of its F box induces tumorigenesis in transgenic mice.
PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors.
Peritumoral plasmacytoid dendritic cells predict a poor prognosis for intrahepatic cholangiocarcinoma after curative resection.
Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study.
Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.
Pharmacological Vitamin C Treatment Impedes the Growth of Endogenous Glutamine-Dependent Cancers by Targeting Glutamine Synthetase.
Position Is Destiny: Metabolism and Cell Identity.
Postoperative Adjuvant Transarterial Chemoembolization Improves Short-Term Prognosis of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus: A Propensity-Score Matching Study.
PPAR-alpha agonist treatment increases trefoil factor family-3 expression and attenuates apoptosis in the liver tissue of bile duct-ligated rats.
Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis.
Prognostic nomogram for predicting 5-year overall survival in Chinese patients with high-grade osteosarcoma.
Protein kinase C-activating tumor promoters enhance the differentiation of astrocytes in aggregating fetal brain cell cultures.
Proteome analysis of chemically induced mouse liver tumors with different genotype.
Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas.
Redox modulation of NF-kappaB nuclear translocation and DNA binding in metastatic melanoma. The role of endogenous and gamma-glutamyl transferase-dependent oxidative stress.
Regulation of glutamine synthetase in human breast carcinoma cells and experimental tumors.
Relationship between serum gamma-glutamyl transferase level and colorectal adenoma.
RESULTS OF IMMUNOHISTOCHEMISTRY IN THE DIFFERENTIAL DIAGNOSIS OF EARLY HEPATOCELLULAR CARCINOMA AND NODULES WITH HIGH-GRADE DYSPLASIA IN PATIENTS WITH CIRRHOSIS.
Role of Oxidative Stress in the Promoting Activities of PCBs.
Serum tumor markers for detection of hepatocellular carcinoma.
Steatotic and Nonsteatotic Scirrhous hepatocellular carcinomas reveal distinct Clinicopathological features.
Stratification of population in NHANES 2009-2014 based on exposure pattern of lead, cadmium, mercury, and arsenic and their association with cardiovascular, renal and respiratory outcomes.
Successful resection of a huge hepatocellular adenoma.
Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.
The Applicability of a Human Immunohistochemical Panel to Mouse Models of Hepatocellular Neoplasia.
The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
The pathway of glutamate oxidation in isolated mitochondria from the avian hepatomatous growth induced by MC-29 virus.
The Predictive Value of Pre-therapeutic Serum Gamma-glutamyl transferase in Efficacy and Adverse Reactions to Neoadjuvant Chemotherapy among Breast Cancer Patients.
The relationship between an inflammation-based prognostic score (Glasgow Prognostic Score) and changes in serum biochemical variables in patients with advanced lung and gastrointestinal cancer.
The relationship between the presence and site of cancer, an inflammation-based prognostic score and biochemical parameters. Initial results of the Glasgow Inflammation Outcome Study.
The role of glutamine synthetase in the diagnosis of cerebral tumours.
The truncated glucocorticoid receptor in the P1798 mouse lymphosarcoma is associated with resistance to glucocorticoid lysis but not to other glucocorticoid-induced functions.
Thymoquinone supplementation ameliorates acute endotoxemia-induced liver dysfunction in rats.
Transcriptional regulation of the rat glutamine synthetase gene by tumor necrosis factor-alpha.
Transcriptomic and Proteomic Analysis of Steatohepatitic Hepatocellular Carcinoma Reveals Novel Distinct Biologic Features.
Transitional cell carcinoma of the ureter: prognostic factors influencing progression and survival.
Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation.
Tumor Formation in Liver of Conditional {beta}-Catenin-Deficient Mice Exposed to a Diethylnitrosamine / Phenobarbital Tumor Promotion Regimen.
Tumor regulation of hepatic glutamine metabolism.
Tumorigenicity of cell lines (VMDk) derived from a spontaneous murine astrocytoma. Histology, fine structure and immunocytochemistry of tumours.
Tumour-associated isoenzymes of gamma-glutamyl transferase in the serum of patients with hepatocellular carcinoma.
Unlinked control of multiple glucocorticoid-induced processes in HTC cells.
Update on the pathology of liver neoplasms.
[13N]Ammonia and L-[amide-13N]glutamine metabolism in glutaminase-sensitive and glutaminase-resistant murine tumors.
[Activity of enzymes of glutathione metabolism and regulation by cAMP in human tumors]
[Gamma-glutamyltransferase and alkaline phosphatase in the serum and saliva of patients with hepatic tumors and hepatic cirrhosis]
[Glutamine synthetase activity in the erythrocytes of cancer patients and in the erythrocytes, liver, kidneys and brain of normal rats and rats with Guerin's tumor]
[Immunohistochemical study of glutamine synthetase expression in normal human brain and intracranial tumors]
[Method of diagnosing liver tumors]
[The regulatory action of dipeptide "Deglutam" on the glutamine metabolized enzymes in the carcinosarcoma SM-1 cells]
[The relevance of the trace elements zinc and iron in the milk fever disease of cattle].
Neoplasms, Neuroepithelial
Dysembryoplastic neuroepithelial tumors: A single-institutional series with special reference to glutamine synthetase expression.
Nephritis
[Urinary gamma-glutamyl transferase in renal toxicology of the rat. Bases of its use and significance in acute mercurial nephritis]
Nephrosis
Erythrocytic enzymes and amino acids related to glutamic acid metabolism in childhood hypoproteinemic states.
Nephrotic Syndrome
Activity of serum enzymes in puromycin aminonucleoside-induced nephrotic syndrome.
[A method of separate determination of enzymuria associated with impairment of glomerular filtration in kidney tissue]
Nervous System Diseases
Assessment of glutamine synthetase activity by [13N]ammonia uptake in living rat brain.
Caloric restriction increases hippocampal glutamate uptake and glutamine synthetase activity in Wistar rats.
Glutamine Synthetase: Role in Neurological Disorders.
Neural Tube Defects
Amniotic fluid gamma-glutamyl transferase activity in trisomy 21 and neural tube defects.
Neuroblastoma
Derepression of the glutamine synthetase in neuroblastoma cells at low concentrations of glutamine.
Neurodegenerative Diseases
A brain proteome profile in rats exposed to methylmercury or thimerosal (ethylmercury).
Glutamine Synthetase 1 Increases Autophagy Lysosomal Degradation of Mutant Huntingtin Aggregates in Neurons, Ameliorating Motility in a Drosophila Model for Huntington's Disease.
Inactivation of astrocytic glutamine synthetase by hydrogen peroxide requires iron.
Interleukin-1 beta and tumor necrosis factor-alpha suppress dexamethasone induction of glutamine synthetase in primary mouse astrocytes.
Neuromuscular Diseases
[Studies on enzyme activities relating to amino acid mobilization in biopsied muscles]
Neuromyelitis Optica
CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD.
Neutropenia
A Phase Ib Study of NUC-1031 in Combination with Cisplatin for the First-Line Treatment of Patients with Advanced Biliary Tract Cancer (ABC-08).
CONKO-006: A randomised double-blinded phase IIb-study of additive therapy with gemcitabine + sorafenib/placebo in patients with R1 resection of pancreatic cancer - Final results.
Population pharmacokinetics of posaconazole in neutropenic patients receiving chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome.
Non-alcoholic Fatty Liver Disease
A comparison of the cardiometabolic profile of black South Africans with suspected non-alcoholic fatty liver disease (NAFLD) and excessive alcohol use.
Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease.
Elevated Liver Enzymes in Patients with Type 2 Diabetes Mellitus and Non-alcoholic Fatty Liver Disease.
Estimation of gamma-glutamyl transferase as a suitable simple biomarker of the cardiovascular risk in children with non-alcoholic fatty liver disease.
Evaluation of circulating zonulin as a potential marker in the pathogenesis of nonalcoholic fatty liver disease.
Fruit Fiber Consumption Specifically Improves Liver Health Status in Obese Subjects under Energy Restriction.
Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease: The Gut and Obesity Asia initiative.
Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011.
Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens.
Including Fibroblast Growth Factor-21 in Combined Biomarker Panels Improves Predictions of Liver Steatosis Severity in Children.
Large-scale analysis of factors influencing nonalcoholic fatty liver disease and its relationship with liver enzymes.
Late nonalcoholic Fatty liver disease with cirrhosis: a pathologic case of lost or mistaken identity.
Markers of the hepatic component of the metabolic syndrome as predictors of mortality in renal transplant recipients.
Metabolic differences between male and female adolescents with non-alcoholic fatty liver disease, as detected by ultrasound.
Metabolic risk factors, genetic predisposition, and risk of severe liver disease in Chinese: a prospective study of 0.5 million people.
Non-Alcoholic Fatty Liver Disease Modifies Serum Gamma-Glutamyl Transferase in Cigarette Smokers.
Persistent elevation of liver function enzymes within the reference range is associated with increased cardiovascular risk in young adults: the Bogalusa Heart Study.
Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis.
Profile of liver enzymes in non-alcoholic fatty liver disease in patients with impaired glucose tolerance and newly detected untreated type 2 diabetes.
SGLT2 inhibitors in patients with type 2 diabetes with non-alcoholic fatty liver diseases: an umbrella review of systematic reviews.
The association between adherence to the Mediterranean diet and hepatic steatosis: cross-sectional analysis of two independent studies, the UK Fenland Study and the Swiss CoLaus Study.
The effects of low carbohydrate diets on liver function tests in nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials.
The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease.
The prevalence of non-alcoholic fatty liver disease in healthy young persons.
The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes.
The roles of obesity and gender on the relationship between metabolic risk factors and non-alcoholic fatty liver disease in Koreans.
Utility of a new model to diagnose an alcohol basis for steatohepatitis.
Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement.
[Clinical features of non-alcoholic fatty liver disease and its relationship with serum C-peptide levels in patients with latent autoimmune diabetes in adults].
Obesity
Additive effects of moderate drinking and obesity on serum gamma-glutamyl transferase activity.
Additive effects of moderate drinking and obesity on serum gamma-glutamyl transferase.
Effect of body mass and other factors on serum liver enzyme levels in men attending for well population screening.
Effect of the CD14 promoter polymorphism on liver function tests and its association with alcohol and obesity.
Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease: The Gut and Obesity Asia initiative.
Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011.
Influences of pregravid liver enzyme levels on the development of gestational diabetes mellitus.
Obesity, albuminuria, and gamma-glutamyl transferase predict incidence of hypertension in indigenous Australians in rural and remote communities in northern Australia.
Predictive accuracy of the SCORE risk function for cardiovascular disease in clinical practice: a prospective evaluation of 44 649 Austrian men and women.
Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index.
Serum gamma-glutamyl transferase level is an independent predictor of incident hypertension in korean adults.
Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort.
Obesity, Abdominal
Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease.
Ocular Hypertension
5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model.
Glutamate-induced glutamine synthetase expression in retinal Muller cells after short-term ocular hypertension in the rat.
Oligodendroglioma
Immunohistochemical Characterization of Spontaneous and Acrylonitrile-induced Brain Tumors in the Rat.
Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth.
Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas.
Olivopontocerebellar Atrophies
Cerebellar glutamate metabolizing enzymes in spinocerebellar ataxia type I.
Opisthorchiasis
[Biochemical characteristics of hepatic functions in different clinical forms of chronic opisthorchiasis]
[Changes in the activity of gamma-glutamyltransferase and cholinesterase in the blood of patients with opisthorchiasis at different phases of the disease]
Optic Nerve Injuries
Voluntary running delays primary degeneration in rat retinas after partial optic nerve transection.
Ornithine Carbamoyltransferase Deficiency Disease
Variable X-chromosome inactivation and enlargement of pericentral glutamine synthetase zones in the liver of heterozygous females with OTC deficiency.
Osteoarthritis
[Localization of carbohydrate component in human synovial lining cells with fluorescent lectins and enzyme digestion]
Osteomalacia
Peri-operative derangement in liver function tests in older patients with neck of femur fracture.
Osteonecrosis
Gamma-Glutamyl Transferase: A Useful Marker of Habitual Drinking in Cases of Alcohol-Associated Osteonecrosis of the Femoral Head.
Osteoporosis
Blood levels related to the Z-score of bone mineral density in young males and females.
Peri-operative derangement in liver function tests in older patients with neck of femur fracture.
Osteosarcoma
Glucocorticoids induce glutamine synthetase expression in human osteoblastic cells: a novel observation in bone.
Ovarian Neoplasms
High expression of glutamate-ammonia ligase is associated with unfavorable prognosis in patients with ovarian cancer.
Hypoxia-inducible factor-1? promotes cell survival during ammonia stress response in ovarian cancer stem-like cells.
N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages.
Ovarian cancer therapeutic potential of glutamine depletion based on GS expression.
Reprogramming of glutamine metabolism via glutamine synthetase silencing induces cisplatin resistance in A2780 ovarian cancer cells.
Serum enzyme changes during chemotherapy for ovarian cancer.
Overweight
Chronic fatigue syndrome and related disorders in UK veterans of the Gulf War 1990-1991: results from a two-phase cohort study.
Gamma-glutamyl Transferase Is Strongly Associated With Degree of Overweight and Sex.
Including Fibroblast Growth Factor-21 in Combined Biomarker Panels Improves Predictions of Liver Steatosis Severity in Children.
Pancreatic Diseases
Renal handling of amylase and immunoreactive trypsin in pancreatic cancer and chronic pancreatitis.
Pancreatic Neoplasms
Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1.
Renal handling of amylase and immunoreactive trypsin in pancreatic cancer and chronic pancreatitis.
Pancreatitis
Rare Variants in Triglycerides-Related Genes Increase Pancreatitis Risk in Multifactorial Chylomicronemia Syndrome.
Tissue-specific regulation of glutamine synthetase gene expression in acute pancreatitis is confirmed by using interleukin-1 receptor knockout mice.
Pancreatitis, Chronic
Renal handling of amylase and immunoreactive trypsin in pancreatic cancer and chronic pancreatitis.
Paraganglioma
Glutamine Synthetase Immunoreactivity in Peritumoral Hyperplasia in Liver: ?Case Report of a Metastatic Paraganglioma With Focal Nodular Hyperplasia-Like Changes and Review of an Additional 54 Liver Masses.
Parkinson Disease
Glutamine synthetase activity in patients with Parkinson's disease.
Perinatal Death
Congenital glutamine deficiency with glutamine synthetase mutations.
Glutamine synthetase deficiency in murine astrocytes results in neonatal death.
Plant Diseases
Growth Regulation and Other Secondary Effects of Herbicides
Pleural Effusion
[Gamma-glutamyl transferase, leucine aminopeptidase and creatine kinase in the pleural fluid and serum of patients with pleural effusion of neoplastic and infectious origin]
Pneumonia
Variation in plasma lipid and lipoprotein concentrations in community-acquired pneumonia a six-month prospective study.
Zootechnical and health performance of Holstein x Gir crossbred calves.
Polycystic Kidney, Autosomal Dominant
Carbohydrate antigen 19-9 is significantly elevated in autosomal dominant polycystic kidney disease.
Polycystic Ovary Syndrome
Are serum gamma-glutamyl transferase, high-sensitivity C-reactive protein, and ischaemia-modified albumin useful in diagnosing PCOS?
Polycythemia
Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease.
Porphyria Cutanea Tarda
Clinical value of serum gamma-glutamyl transferase estimation in porphyria cutanea tarda.
Porphyria, Acute Intermittent
Markers for vulnerability in acute porphyria. A hypothesis paper.
Porphyrias
Changes in some intestinal enzyme activities in experimental hexachlorobenzene-induced porphyria and modifying effects of diet.
Clinical value of serum gamma-glutamyl transferase estimation in porphyria cutanea tarda.
Markers for vulnerability in acute porphyria. A hypothesis paper.
Pre-Eclampsia
Optimal laboratory panel for predicting preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Lymphoblastic Leukemia Presenting with Liver Infiltration and Severe Lactic Acidosis.
Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.
Presence and steroid inducibility of glutamine synthetase in human leukemic cells.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.
Prediabetic State
Effects of hepatitis B virus infection, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase on prediabetes and diabetes mellitus: A cohort study.
Prehypertension
Association between serum gamma-glutamyl transferase level and prehypertension among community-dwelling men.
Changes in serum gamma-glutamyl transferase and blood pressure levels in subjects with normal blood pressure and prehypertension.
Primary Immunodeficiency Diseases
Oral features of Griscelli syndrome type II: A rare case report.
Prostatic Hyperplasia
Differences in the enzymatic nature and the sugar-chain structure of gamma-glutamyl transferase between normal and carcinomatous human kidney and prostate.
Prostatic Neoplasms
Glucose, lipids and gamma-glutamyl transferase measured before prostate cancer diagnosis and secondly diagnosed primary tumours: a prospective study in the Swedish AMORIS cohort.
[(13)N]Ammonia Positron Emission Tomographic/Computed Tomographic Imaging Targeting Glutamine Synthetase Expression in Prostate Cancer.
[13N]Ammonia Positron Emission Tomographic/Computed Tomographic Imaging Targeting Glutamine Synthetase Expression in Prostate Cancer.
Protein-Energy Malnutrition
Erythrocytic enzymes and amino acids related to glutamic acid metabolism in childhood hypoproteinemic states.
Serum aminotransferases and gamma-glutamyl transferase in protein energy malnutrition.
Proteinuria
Renal tubular damage caused by cylindrospermopsin (cyanotoxin) in mice.
The effect of exercise on urinary gamma-glutamyl transferase and protein levels of volleyball players.
The effect of exercise on urinary gamma-glutamyltransferase and protein levels in elite female karate athletes.
The efficacy of folk medicines in the management of type 2 diabetes mellitus: results of a randomized controlled trial of Syzygium cumini (L.) Skeels.
Urinary gamma-glutamyl transferase (GGT) as a marker of tubular proteinuria in dogs with canine leishmaniasis, using sodium dodecylsulphate (SDS) electrophoresis as a reference method.
[Urinary enzymes as a marker of the preclinical stage of diabetic nephropathy]
Pruritus
Benign recurrent intrahepatic cholestasis.
Intrahepatic Cholestasis Is a Clinically Significant Feature Associated with Natural History of X-Linked Myotubular Myopathy (XLMTM): A Case Series and Biopsy Report.
Psoriasis
[Hepatobiliary System Diseases as the Predictors of Psoriasis Progression].
[Urinary enzymes in the assessment of the early stage of kidney involvement in psoriasis and diabetes mellitus]
Pulmonary Disease, Chronic Obstructive
Serum Gamma-Glutamyl Transferase Activity as a Potential Novel Cardiovascular Biomarker in COPD.
Studies of gamma-glutamyl transferase in alpha-1 antitrypsin deficiency.
Pulmonary Embolism
Elevated gamma glutamyl transferase levels are associated with the location of acute pulmonary embolism. Cross-sectional evaluation in hospital setting.
Gamma-glutamyl transferase and pulmonary embolism.
Pulpitis
Modulation of astroglial glutamine synthetase activity affects nociceptive behaviour and central sensitization of medullary dorsal horn nociceptive neurons in a rat model of chronic pulpitis.
Pyometra
Calculation of urinary enzyme excretion, with renal structure and function in dogs with pyometra.
Urinary gamma-glutamyl transferase and the degree of renal dysfunction in 75 bitches with pyometra.
Renal Insufficiency, Chronic
High levels of both serum gamma-glutamyl transferase and alkaline phosphatase are independent preictors of mortality in patients with stage 4-5 chronic kidney disease.
Liver enzymes in patients with chronic kidney disease undergoing peritoneal dialysis and hemodialysis.
Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review.
Serum Gamma-Glutamyl Transferase and Ferritin Synergistically Associated with the Rate of Chronic Kidney Disease.
The relationship between gamma-glutamyl transferase levels and chronic kidney disease among Appalachian adults.
Reperfusion Injury
Critical Evaluation of the Changes in Glutamine Synthetase Activity in Models of Cerebral Stroke.
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat.
Ursodeoxycholic Acid in Treatment of Non-cholestatic Liver Diseases: A Systematic Review.
Retinal Degeneration
Early postnatal Müller cell death leads to retinal but not optic nerve degeneration in NSE-Hu-Bcl-2 transgenic mice.
Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins.
Retinal Detachment
Amino acid signatures in the detached cat retina.
Basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in vitreous fluid from eyes with retinal detachment complicated by proliferative vitreoretinopathy.
Levels of basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in subretinal fluid from patients with retinal detachment.
Rapid changes in the expression of glial cell proteins caused by experimental retinal detachment.
Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins.
Retinoblastoma
Glutamine synthetase activity in human retinal tissue. Enzyme activity in the normal retina and cortisol induction in cultured cells derived from retinoblastoma.
Reye Syndrome
Successful use of alternate waste nitrogen agents and hemodialysis in a patient with hyperammonemic coma after heart-lung transplantation.
Sarcoma
Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.
The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.
Sarcoma, Avian
Phosphotyrosine in proteins. Stability and quantification.
Sarcopenia
Does Long-Term Intermittent Treatment With Glutamine Improve the Well-being of Fed and Fasted Very Old Rats?
Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011.
Schistosomiasis mansoni
Serum enzyme tests in hepatosplenic schistosomiasis.
Scrapie
Astrocyte gene expression in experimental mouse scrapie.
Expression of glial fibrillary acidic protein and glutamine synthetase genes in the natural scrapie of sheep.
Seizures
A Very Rare Etiology of Hypotonia and Seizures: Congenital Glutamine Synthetase Deficiency.
Acute and long-term effects of chlorpromazine on glutamine synthetase and glutaminase in rat brain.
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Alterations in glutamine synthetase activity by FeCl2-induced focal and kindled amygdaloid seizures.
Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy.
Angiocentric glioma-associated seizures: The possible role of EATT2, pyruvate carboxylase and glutamine synthetase.
Bmi-1 absence causes premature brain degeneration.
Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase.
Comparison of glutamine synthetases from brains of genetically epilepsy prone and genetically epilepsy resistant rats.
Corrigendum to 'Angiocentric glioma-associated seizures: The possible role of EATT2, pyruvate carboxylase and glutamine synthetase [Seizure: European Journal of Epilepsy 86 (2021) 152-154].
Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice.
Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions.
Epilepsy in glioblastoma multiforme: correlation with glutamine synthetase levels.
Functional significance of the activities of glutaminase and ornithine-?-aminotransferase in rat brain.
Glial differences between naïve withdrawal seizure-prone and -resistant mice.
Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy.
Glutamine synthetase induced spinal seizures in rats.
Homozygous GLUL deletion is embryonically viable and leads to glutamine synthetase deficiency.
Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy.
Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy.
Manganese and epilepsy: brain glutamine synthetase and liver arginase activities in genetically epilepsy prone and chronically seizured rats.
Methionine sulfoximine seizures. 8. The dissociation of the convulsant and glutamine synthetase inhibitory effects.
Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis.
Neuron-astrocyte signaling and epilepsy.
Phenotypic differences between fast and slow methionine sulfoximine-inbred mice: seizures, anxiety, and glutamine synthetase.
Phosphinothricin induces epileptic activity via nitric oxide production through NMDA receptor activation in adult mice.
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Recent advances in amino acid and organic acid metabolism.
Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats.
Seizures in the Mongolian gerbil are related to a deficiency in cerebral glutamine synthetase.
Short-term alterations in hippocampal glutamate transport system caused by one-single neonatal seizure episode: Implications on behavioral performance in adulthood.
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity.
Studies on sound-induced epilepsy in mice.
The influence of manganese supplementation on seizure onset and severity, and brain monoamines in the genetically epilepsy prone rat.
The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction.
[Metabolic studies on epileptic seizures. The activity of glutaminase and glutamine synthetase and ammonia metabolism before and during cerebral convulsions]
Seizures, Febrile
Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures.
Sepsis
Cerebral Multimodal Monitoring in Sepsis: An Experimental Study.
Molecular regulation of lung endothelial glutamine synthetase expression.
Nitric oxide signaling gone awry: nitration of glutamine synthetase and hyperammonemia in sepsis.
Primary sclerosing cholangitis associated with severe ulcerative colitis in a young man.
Sepsis increases lung glutamine synthetase expression in the tumor-bearing host.
Small bowel dilation in children with short bowel syndrome is associated with mucosal damage, bowel-derived bloodstream infections, and hepatic injury.
Skin Diseases
Role of glutamine synthetase in angiogenesis beyond glutamine synthesis.
Sleep Apnea, Obstructive
Gamma-glutamyl transferase activity as a predictive marker for severity of obstructive sleep apnea syndrome and concomitant hypertension.
Serum gamma-glutamyl transferase activity is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome.
Serum levels of gamma-glutamyl transferase are associated with cardiovascular disease in obstructive sleep apnea syndrome.
Sleep Deprivation
Paradoxical sleep deprivation increases glutamine synthetase in rat brain.
Spinal Cord Injuries
Down-regulation of glutamine synthetase enhances migration of rat astrocytes after in vitro injury.
Glutamine synthetase activities in spinal white and gray matter 7 days following spinal cord injury in rats.
Temporospatial expression and cellular localization of glutamine synthetase following traumatic spinal cord injury in adult rats.
Spinal Cord Ischemia
Preventive effects of intrathecal methylprednisolone administration on spinal cord ischemia in rats: the role of excitatory amino acid metabolizing systems.
Spinocerebellar Ataxias
Cerebellar glutamate metabolizing enzymes in spinocerebellar ataxia type I.
Starvation
?54-Dependent Response to Nitrogen Limitation and Virulence in Burkholderia cenocepacia Strain H111.
A defect in nir1, a nirA-like transcription factor, confers morphological abnormalities and loss of pathogenicity in Colletotrichum acutatum.
A theoretical steady state analysis indicates that induction of Escherichia coli glnALG operon can display all-or-none behavior.
Amino acid metabolism enzyme activities in the obese Zucker rat.
Amino-acid metabolism enzyme activities in rat white adipose tissue.
Changes in Viability, Cell Composition, and Enzyme Levels During Starvation of Continuously Cultured (Ammonia-Limited) Selenomonas ruminantium.
Characterization of pII family (GlnK1, GlnK2, and GlnB) protein uridylylation in response to nitrogen availability for Rhodopseudomonas palustris.
Characterization of Vesicle Differentiation Mutants of Frankia casuarinae.
Control of phycobiliprotein proteolysis and heterocyst differentiation in Anabaena.
Effect of 24-hour starvation on amino acid pool composition and enzyme activities of rat brown adipose tissue.
Essentiality of the glnA gene in Haloferax mediterranei: gene conversion and transcriptional analysis.
Global gene expression profiling of Bacillus subtilis in response to ammonium and tryptophan starvation as revealed by transcriptome and proteome analysis.
Glutamine synthetase activity in leaves of Zea mays L. as influenced by magnesium status.
Glutamine synthetase from the marine cyanobacteria Prochlorococcus spp: characterization, phylogeny and response to nutrient limitation.
Glutamine Synthetase Sensitivity to Oxidative Modification during Nutrient Starvation in Prochlorococcus marinus PCC 9511.
Growth conditions and inactivation of the uridylylation cycle of the glutamine synthetase regulatory system in permeabilized cells of E. coli.
In Situ Glutamine Synthetase Activity in a Marine Unicellular Alga (Development of a Sensitive Colorimetric Assay and the Effects of Nitrogen Status on Enzyme Activity).
In situ measurement of glutamate concentrations in the periportal, intermediate, and pericentral zones of rat liver.
Induction of Arabidopsis tryptophan pathway enzymes and camalexin by amino acid starvation, oxidative stress, and an abiotic elicitor.
Integrated analysis of transcriptome and metabolites reveals an essential role of metabolic flux in starch accumulation under nitrogen starvation in duckweed.
Metabolic enzymes in glial cells of the honeybee brain and their associations with aging, starvation and food response.
New insights towards the function of glutamate dehydrogenase revealed during source-sink transition of tobacco (Nicotiana tabacum) plants grown under different nitrogen regimes.
Nitrogen control of the glnN gene that codes for GS type III, the only glutamine synthetase in the cyanobacterium Pseudanabaena sp. PCC 6903.
Nitrogen Starvation Acclimation in Synechococcus elongatus: Redox-Control and the Role of Nitrate Reduction as an Electron Sink.
Nitrogen Starvation and the Regulation of Glutamine Synthetase in Agmenellum quadruplicatum.
Nitrogen Starvation and TorC1 Inhibition Differentially Affect Nuclear Localization of the Gln3 and Gat1 Transcription Factors Through the Rare Glutamine tRNACUG in Saccharomyces cerevisiae.
Nitrogen starvation in synechococcus PCC 7942: involvement of glutamine synthetase and NtcA in phycobiliprotein degradation and survival
Nitrogen starvation induces extensive changes in the redox proteome of Prochlorococcus sp. strain SS120.
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways.
Purification and characterization of a new type of glutamine synthetase from cyanobacteria.
Regulation of GlnK activity: modification, membrane sequestration and proteolysis as regulatory principles in the network of nitrogen control in Corynebacterium glutamicum.
Regulation of glutamine synthetase activity in the unicellular cyanobacterium Synechocystis sp. strain PCC 6803 by the nitrogen source: effect of ammonium.
Regulation of Glutamine Synthetase by Light and during Nitrogen Deficiency in Synchronous Chlorella sorokiniana.
Regulation of glutamine synthetase from Saccharomyces cerevisiae by repression, inactivation and proteolysis.
Role of glucocorticoids in increased muscle glutamine production in starvation.
Sporulation of Streptomyces griseus in submerged culture.
Starvation alters the activity and mRNA level of glutaminase and glutamine synthetase in the rat intestine.
The actinorhizal root-nodule symbiont Frankia sp. strain CpI1 has two glutamine synthetases.
Three regulatory systems control expression of glutamine synthetase in Saccharomyces cerevisiae at the level of transcription.
Three regulatory systems control production of glutamine synthetase in Saccharomyces cerevisiae.
[Features of the interconversion of alpha-ketoglutarate--glutamate in brain mitochondria of exothermic animals during hibernation]
Status Epilepticus
Changes in extracellular neurotransmitters in the cerebrum of familial idiopathic epileptic shetland sheepdogs using an intracerebral microdialysis technique and immunohistochemical study for glutamate metabolism.
Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats.
Stevens-Johnson Syndrome
Efficacy, tolerability, and side effects of oxcarbazepine monotherapy: a prospective study in adult and elderly patients with newly diagnosed partial epilepsy.
Stomach Neoplasms
Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth.
Stroke
Critical Evaluation of the Changes in Glutamine Synthetase Activity in Models of Cerebral Stroke.
Effects of Gamma-Glutamyl Transferase on Stroke Occurrence Mediated by Atrial Fibrillation.
Gamma-glutamyl transferase predicts future stroke: A Korean nationwide study.
Is serum gamma-glutamyl transferase a good marker of alcohol intake in stroke patients?
Post-ischemic administration of nimodipine following focal cerebral ischemic-reperfusion injury in rats alleviated excitotoxicity, neurobehavioural alterations and partially the bioenergetics.
Serum Gamma-Glutamyl Transferase Activity as a Potential Novel Cardiovascular Biomarker in COPD.
Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke.
Stroke and alcohol intake in a hospital population. A case-control study.
Sum of two catalytic activities of the glutamine synthetase enzyme is a blood biomarker for stroke and is optimized for a rapid diagnostic test.
Subarachnoid Hemorrhage
Serum Gamma-glutamyl Transferase Levels Predict Functional Outcomes after Aneurysmal Subarachnoid Hemorrhage.
Teratoma
Cell density-dependent stimulation of glutamine synthetase activity in cultured mouse teratoma cells.
Thrombocytopenia
A Phase Ib Study of NUC-1031 in Combination with Cisplatin for the First-Line Treatment of Patients with Advanced Biliary Tract Cancer (ABC-08).
Clinicopathologic findings of naturally occurring Rabbit Hemorrhagic Disease Virus 2 infection in pet rabbits.
CONKO-006: A randomised double-blinded phase IIb-study of additive therapy with gemcitabine + sorafenib/placebo in patients with R1 resection of pancreatic cancer - Final results.
Efficacy and Safety of Trastuzumab Emtansine in Her2 Positive Metastatic Breast Cancer: Real-World Experience.
Hepatitis C virus and human T-cell lymphotropic virus type 1 co-infection: impact on liver disease, virological markers, and neurological outcomes.
Prenatal treatment of congenital human cytomegalovirus infection by fetal intravascular administration of ganciclovir.
Thrombocytosis
Correlation between serum gamma-glutamyl transferase activity and the platelet count.
Expression of intrahepatic CD3, CD4, and CD8 T cells in biliary atresia.
Stauffer's syndrome variant with cholestatic jaundice: a case report.
Thrombosis
A Phase Ib Study of NUC-1031 in Combination with Cisplatin for the First-Line Treatment of Patients with Advanced Biliary Tract Cancer (ABC-08).
Elevated gamma glutamyl transferase levels are associated with the location of acute pulmonary embolism. Cross-sectional evaluation in hospital setting.
Graft histology characteristics in long-term survivors of pediatric liver transplantation.
Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma.
Thyrotoxicosis
Serum gamma-glutamyl transferase activity in thyrotoxicosis.
Trauma, Nervous System
Cerebellar glutamine synthetase in children after hypoxia or ischemia.
Glial fibrillary acidic protein messenger RNA and glutamine synthetase activity after nervous system injury.
Tuberculosis
Adenylylation and catalytic properties of Mycobacterium tuberculosis glutamine synthetase expressed in Escherichia coli versus mycobacteria.
Adjunctive Immunotherapeutic Efficacy of N-Formylated Internal Peptide of Mycobacterial Glutamine Synthetase in Mouse Model of Tuberculosis.
All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis.
An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase selectively blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: extracellular proteins as potential novel drug targets.
Bisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase.
Characterization of protein acyltransferase function of recombinant purified GlnA1 from Mycobacterium tuberculosis: A moon lighting property.
Cloning and expression of mycobacterial glutamine synthetase gene in Escherichia coli.
Computational Sampling and Simulation Based Assessment of Novel Mycobacterium tuberculosis Glutamine Synthetase Inhibitors: Study Involving Structure Based Drug Design and Free Energy Perturbation.
Development of a simple assay protocol for high-throughput screening of Mycobacterium tuberculosis glutamine synthetase for the identification of novel inhibitors.
Development of a simple high-throughput screening protocol based on biosynthetic activity of Mycobacterium tuberculosis glutamine synthetase for the identification of novel Inhibitors.
Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform.
Evaluation of Mycobacterium tuberculosis genes involved in resistance to killing by human macrophages.
Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery.
Expression and efficient export of enzymatically active Mycobacterium tuberculosis glutamine synthetase in Mycobacterium smegmatis and evidence that the information for export is contained within the protein.
Extracellular enzyme activities potentially involved in the pathogenicity of Mycobacterium tuberculosis.
Functional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis.
Functionalized 3-amino-imidazo[1,2-a]pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors.
glnE is an essential gene in Mycobacterium tuberculosis.
Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis.
Glutamine synthetase GlnA1 is essential for growth of Mycobacterium tuberculosis in human THP-1 macrophages and guinea pigs.
Glutamine synthetase of Mycobacterium tuberculosis: extracellular release and characterization of its enzymatic activity.
Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation.
High extracellular levels of Mycobacterium tuberculosis glutamine synthetase and superoxide dismutase in actively growing cultures are due to high expression and extracellular stability rather than to a protein-specific export mechanism.
HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase.
Identification of Mycobacterium tuberculosis Peptides in Serum Extracellular Vesicles from Persons with Latent Tuberculosis Infection.
Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis.
Immunotherapeutic potential of N-formylated peptides of ESAT-6 and glutamine synthetase in experimental tuberculosis.
Impact of adenylyltransferase GlnE on nitrogen starvation response in Corynebacterium glutamicum.
Independent transcription of glutamine synthetase (glnA2) and glutamine synthetase adenylyltransferase (glnE) in Mycobacterium bovis and Mycobacterium tuberculosis.
Inhibition of glutamine synthetase: a potential drug target in Mycobacterium tuberculosis.
Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo.
Low expression level of glnA1 accounts for absence of cell wall associated poly-l-glutamate/glutamine in Mycobacterium smegmatis.
Methionine Sulfoximine Resistance in Mycobacterium tuberculosis Is Due to a Single Nucleotide Deletion Resulting in Increased Expression of the Major Glutamine Synthetase, GlnA1.
Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase.
Microwave-Promoted Palladium(II)-Catalyzed C--P Bond Formation by Using Arylboronic Acids or Aryltrifluoroborates.
Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline.
Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation.
Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: synthesis, biological evaluation and X-ray crystallographic studies.
New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.
Preliminary crystallographic studies on glutamine synthetase from Mycobacterium tuberculosis.
Protection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine model.
Reaction Mechanism of Mycobacterium Tuberculosis Glutamine Synthetase Using Quantum Mechanics/Molecular Mechanics Calculations.
Regulation of nitrogen metabolism in Mycobacterium tuberculosis: a comparison with mechanisms in Corynebacterium glutamicum and Streptomyces coelicolor.
Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors.
Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights.
Synthesis, In Vitro Screening and Docking Studies of New Thiosemicarbazide Derivatives as Antitubercular Agents.
The Unexpected Essentiality of glnA2 in Mycobacterium smegmatis Is Salvaged by Overexpression of the Global Nitrogen Regulator glnR, but Not by L-, D- or Iso-Glutamine.
Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication.
Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors.
Virtual screening to identify novel potential inhibitors for Glutamine synthetase of Mycobacterium tuberculosis.
[Analysis on human T cell epitopes polymorphisms of five specific antigens of Mycobacterium tuberculosis in 13 areas of China].
Tuberculosis, Pulmonary
Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo.
Tuberculosis, Renal
Salubrious effect of vitamin E supplementation on renal stone forming risk factors in urogenital tuberculosis patients.
Urinary Bladder Neoplasms
Hydrolytic enzymes in normal and neoplastic human bladder tissue.
Urolithiasis
Tubulopathy in nephrolithiasis: consequence rather than cause.
Vascular Diseases
Gamma-glutamyl transferase predicts future stroke: A Korean nationwide study.
Vertigo
The tolerability and safety profile of eslicarbazepine acetate in neurological disorders.
Virus Diseases
Role of gamma-glutamyl transferase activity in patients with chronic hepatitis C virus infection.
Vitreoretinopathy, Proliferative
Basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in vitreous fluid from eyes with retinal detachment complicated by proliferative vitreoretinopathy.
Wasting Syndrome
Skeletal muscle glucocorticoid receptor and glutamine synthetase activity in the wasting syndrome in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Whooping Cough
[Changes in the biological properties of the pertussis microbe exposed to antibiotics]
[Glutamine synthetase content and immunochemical analysis of different strains of Bordetella pertussis]
Yellow Fever
Aedes aegypti glutamine synthetase: expression and gene structure.