6.3.1.2: glutamine synthetase

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For detailed information about glutamine synthetase, go to the full flat file.

Word Map on EC 6.3.1.2

6.3.1.2

aminotransferase

gg

glial

astrocyte

nitrate

bilirubin

sulfoximine

alt

cerebral

hepatocytes

retina

fibrillary

cholesterol

glutaminase

albumin

transaminase

creatinine

adenylylation

triglyceride

nodule

astroglial

bile

neurotransmitter

excitatory

c-reactive

uric

no3

neurotoxicity

glutamatergic

nitrogenase

hyperammonemia

excitotoxicity

cirrhosis

l-methionine

anabaena

periportal

pii

cholestasis

gamma-gt

photorespiratory

n2-fixing

pericentral

gamma-glutamyltransferase

photorespiration

corpuscular

adenylyltransferase

drinker

assimilatory

remobilization

drug development

synthesis

pharmacology

diagnostics

heterocysts

medicine

analysis

Reaction

Synonyms

AmGLN1, ATP glutamate-ammonia ligase, Chloroplast GS2, Clone lambda-GS28, Clone lambda-GS31, Clone lambda-GS8, Cytoplasmic GS3, Cytosolic GS1, gamma-glutamyl transferase, gamma-glutamyl:ammonia ligase, gamma-glutamylhydroxamate synthetase, Gln isozyme alpha, Gln isozyme beta, Gln isozyme gamma, Gln synthetase, GLN1,1, GLN1,2, GLN1,3, GLN1,4, GLN1-1, GLN1-2, Gln1;1, Gln1;2, Gln1;3, Gln1;4, Gln1;5, GLN2, GlnA, glnA-1, GlnA1, GlnA2, GlnA3, GlnA4, GlnN, GlnR, GluA, GLUL, Glutamate--ammonia ligase, glutamate-ammonia ligase, Glutamine synthetase, glutamine synthetase cytosolic isozyme 1, glutamine synthetase cytosolic isozyme 2, glutamine synthetase I, glutamine synthetase type II, glutamine synthetase type III, Glutamylhydroxamic synthetase, GS, GS type I, GS type-1, GS(1), GS-II, GS1, GS1 kinase, GS1-1, GS1-2, GS107, GS112, GS117, GS12, GS122, GS1a, GS1beta1, GS1gamma1, GS2, GS2a, GS3, GSI, GSII, GSIII, Isozyme delta, L-glutamate:ammonia ligase, L-glutamate:ammonia ligase (ADP-forming), L-Glutamine synthetase, LDBPK_060370, LdGS, MM_0964, MtGS, N47/N48, OsGLN1,1, OsGLN1,2, protein transacetylase, S2205/S2287, SSO0366, Synthetase, glutamine, TAase, type I glutamine synthetase, type III glutamine synthetase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.2 glutamine synthetase

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Results	in table
66	Activating Compound
47140	AA Sequence
38	Application
1	CAS Registry Number
101	Cloned(Commentary)
98	Cofactor
15	Crystallization (Commentary)
4106	Disease/ Diagnostics
25	Expression
67	General Information
22	General Stability
139	IC50 Value
641	Inhibitors
20	kcat/KM [mM/s]
126	Ki Value [mM]
321	KM Value [mM]
103	Localization
242	Metals/Ions
162	Molecular Weight [Da]
181	Natural Substrates/ Products (Substrates)
770	Organism
8	Oxidation Stability
14	Pathway
630	PDB ID
102	pH Optimum
16	pH Range
9	pH Stability
23	pI Value
22	Posttranslational Modification
94	Protein Variants
100	Purification (Commentary)
30	Reaction
1	Reaction Type
387	Reference
3	Renatured (Commentary)
375	Source Tissue
60	Specific Activity [micromol/min/mg]
15	Storage Stability
566	Substrates and Products (Substrate)
161	Subunits
272	Synonyms
1	Systematic Name
48	Temperature Optimum [°C]
9	Temperature Range [°C]
45	Temperature Stability [°C]
46	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 6.3.1.2 - glutamine synthetase

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1000000

Clostridium pasteurianum

gel filtration

37493

200000

Squalus acanthias

gel filtration, in presence of Mg2+, MgATP2-, and L-Glu the enzyme has a MW of 400000, reversible dissociation from the 400000 MW form to a species of MW 200000 in the absence of MgATP2- and L-Glu