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6.3.1.2: glutamine synthetase

This is an abbreviated version!
For detailed information about glutamine synthetase, go to the full flat file.

Word Map on EC 6.3.1.2

Reaction

ATP
+
L-glutamate
+
NH3
=
ADP
+
phosphate
+
L-glutamine

Synonyms

AmGLN1, ATP glutamate-ammonia ligase, Chloroplast GS2, Clone lambda-GS28, Clone lambda-GS31, Clone lambda-GS8, Cytoplasmic GS3, Cytosolic GS1, gamma-glutamyl transferase, gamma-glutamyl:ammonia ligase, gamma-glutamylhydroxamate synthetase, Gln isozyme alpha, Gln isozyme beta, Gln isozyme gamma, Gln synthetase, GLN1,1, GLN1,2, GLN1,3, GLN1,4, GLN1-1, GLN1-2, Gln1;1, Gln1;2, Gln1;3, Gln1;4, Gln1;5, GLN2, GlnA, glnA-1, GlnA1, GlnA2, GlnA3, GlnA4, GlnN, GlnR, GluA, GLUL, Glutamate--ammonia ligase, glutamate-ammonia ligase, Glutamine synthetase, glutamine synthetase cytosolic isozyme 1, glutamine synthetase cytosolic isozyme 2, glutamine synthetase I, glutamine synthetase type II, glutamine synthetase type III, Glutamylhydroxamic synthetase, GS, GS type I, GS type-1, GS(1), GS-II, GS1, GS1 kinase, GS1-1, GS1-2, GS107, GS112, GS117, GS12, GS122, GS1a, GS1beta1, GS1gamma1, GS2, GS2a, GS3, GSI, GSII, GSIII, Isozyme delta, L-glutamate:ammonia ligase, L-glutamate:ammonia ligase (ADP-forming), L-Glutamine synthetase, LDBPK_060370, LdGS, MM_0964, MtGS, N47/N48, OsGLN1,1, OsGLN1,2, protein transacetylase, S2205/S2287, SSO0366, Synthetase, glutamine, TAase, type I glutamine synthetase, type III glutamine synthetase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.2 glutamine synthetase

IC50 Value

IC50 Value on EC 6.3.1.2 - glutamine synthetase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.033
(2S)-2-amino-4-(methylsulfonyl)butanoic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.056 - 0.058
(2S,5R)-2,6-diamino-5-hydroxyhexanoic acid
Mycobacterium tuberculosis
dependent on the solvent, pH 7.5, 22°C
0.447
([[(2,4-dichlorophenyl)methyl]amino]methylene)bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.331
([[(2,5-dichlorophenyl)methyl]amino]methylene)bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0025
1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-8-(morpholin-4-yl)-3,7-dihydro-1H-purine-2,6-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0025
1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-8-morpholin-4-yl-purine-2,6-dione
Mycobacterium tuberculosis
-
0.017
1-[(3,4-dichlorophenyl)methyl]-8-[(2-methoxyethyl)amino]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.01
2-(3-aminophenyl)-6-bromo-N-cyclopentylimidazo[1,2-a]pyridin-3-amine
Mycobacterium tuberculosis
-
-
0.026
2-amino-4-(hydroxyamino)butanoic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.025
2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-5-phenyl-1H-imidazole
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
2-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyrimidine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.0063
2-[4-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenoxy]acetamide
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.003
2-[4-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenoxy]ethan-1-ol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0083
2-[[4-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenyl](methyl)amino]ethan-1-ol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.053
3,4-dichlorophenylethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.082
3,5-difluorophenylaminoethylidenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.00002
3-[2-tert-butyl-5-(pyridin-4-yl)-1H-imidazol-4-yl]quinoline
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.025
3-[4-(6-methoxynaphthalen-2-yl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.0006
3-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]benzoic acid
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0014
3-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00038
3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]benzoic acid
0.0033
3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]phenol
0.125
4-methylphenylethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0022
4-[2-ethyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.0012
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]-2-fluoropyridine
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.000049
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridin-2-amine
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0031
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
0.025
4-[4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
4-[4-(6-methoxynaphthalen-2-yl)-2-(1H-pyrrol-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
4-[4-(6-methoxynaphthalen-2-yl)-2-(2-phenylpropan-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
4-[4-(6-methoxynaphthalen-2-yl)-2-methyl-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
4-[4-(6-methoxynaphthalen-2-yl)-2-phenyl-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.000219
5-(2-methoxyethyl)-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000066
5-(3-methylbutyl)-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000007
5-(but-3-en-1-yl)-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000663
5-benzyl-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000456
5-cyclopropyl-9-(pyridin-2-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00017
5-methyl-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.025
5-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyrimidine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.000084
5-[3-(dimethylamino)propyl]-9-(3-methoxyphenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000857
5-[3-(dimethylamino)propyl]-9-(pyridin-2-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000131
5-[3-(dimethylamino)propyl]-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0019
5-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0025 - 0.0088
5-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenol
0.0048
5-[6-iodo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenol
Mycobacterium tuberculosis
-
-
0.0058
6-bromo-N-butyl-2-[4-[2-(dimethylamino)ethoxy]phenyl]imidazo[1,2-a]pyridin-3-amine
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00061
9-(3-chlorophenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000051
9-(3-methoxyphenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000031
9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.007
9-(quinolin-5-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00003
9-bromo-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000031
9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000333
9-phenyl-5-(prop-2-en-1-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.2 - 30
AMP
0.244
benzylethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
31 - 350
glycine
1.5 - 140
L-glutamine
3
L-methionine S-sulfoximine
Mycobacterium tuberculosis
-
IC50: 3 mM
0.081
L-methionine sulfoximine
Mycobacterium tuberculosis
pH 7.5, 22°C
0.051
L-methionine-(S)-sulfoximine
Mycobacterium tuberculosis
pH 7.5, 22°C
0.1 - 26
L-methionine-S-sulfoximine
0.0207 - 0.051
methionine sulfoximine
0.231
N-(4-isopropylphenyl)aminomethylenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.249
N-(4-methylphenyl)aminoethalidenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0021
N-(4-oxo-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-9-yl)acetamide
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.174
N-phenylaminoethalidenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.246
N-phenylaminomethylenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.2
Ni2+
Rattus norvegicus
-
pH 6.2, 37°C
0.221
phenylethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.348
phenylmethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0019 - 0.076
Phosphinothricin
0.186
[(2-chloro-3-methylphenyl)(hydroxy)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.358
[(2-chloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.317
[(3,4-dichloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.228
[(3,5-dichloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.269
[(3,5-difluoroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.227
[(3,5-dimethylanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.345
[(3,5-dimethylphenyl)(hydroxy)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.273
[(3-carbamoylanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.24
[(3-chloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.25
[(4-benzylanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.363
[(4-benzylphenyl)(hydroxy)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.375
[(4-chloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.525
[(4-methylanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.178
[2-(2,3-dichlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.18
[2-(2,6-dichloroanilino)ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.194
[2-(2,6-dichlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.082
[2-(3,5-dichloroanilino)ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.45
[2-(3,5-dimethylphenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.286
[2-(4-benzylanilino)ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.13
[2-(4-chlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.294
[2-[(5,6,7,8-tetrahydronaphthalen-1-yl)amino]ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.168
[2-[3,5-bis(trifluoromethyl)anilino]ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0132
[3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]phenyl]methanol
Mycobacterium tuberculosis
-
-
0.0016
[4-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenoxy]acetic acid
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0128
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.286
[[(2,3-dihydro-1H-inden-5-yl)amino]methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0212
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.015
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.0076
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.021
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.278
[[(5,6,7,8-tetrahydronaphthalen-2-yl)amino]methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.256
[[3-(trifluoromethyl)anilino]methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
additional information
additional information
-