Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.033
(2S)-2-amino-4-(methylsulfonyl)butanoic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.056 - 0.058
(2S,5R)-2,6-diamino-5-hydroxyhexanoic acid
Mycobacterium tuberculosis
dependent on the solvent, pH 7.5, 22°C
0.447
([[(2,4-dichlorophenyl)methyl]amino]methylene)bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.331
([[(2,5-dichlorophenyl)methyl]amino]methylene)bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0025
1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-8-(morpholin-4-yl)-3,7-dihydro-1H-purine-2,6-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0025
1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-8-morpholin-4-yl-purine-2,6-dione
Mycobacterium tuberculosis
-
0.017
1-[(3,4-dichlorophenyl)methyl]-8-[(2-methoxyethyl)amino]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.01
2-(3-aminophenyl)-6-bromo-N-cyclopentylimidazo[1,2-a]pyridin-3-amine
Mycobacterium tuberculosis
-
-
0.026
2-amino-4-(hydroxyamino)butanoic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.025
2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-5-phenyl-1H-imidazole
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
2-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyrimidine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.0063
2-[4-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenoxy]acetamide
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.003
2-[4-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenoxy]ethan-1-ol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0083
2-[[4-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenyl](methyl)amino]ethan-1-ol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.053
3,4-dichlorophenylethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.082
3,5-difluorophenylaminoethylidenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.00002
3-[2-tert-butyl-5-(pyridin-4-yl)-1H-imidazol-4-yl]quinoline
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.025
3-[4-(6-methoxynaphthalen-2-yl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.0006
3-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]benzoic acid
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0014
3-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00038
3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]benzoic acid
0.0033
3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]phenol
0.125
4-methylphenylethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0022
4-[2-ethyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.0012
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]-2-fluoropyridine
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.000049
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridin-2-amine
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0031
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
0.025
4-[4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
4-[4-(6-methoxynaphthalen-2-yl)-2-(1H-pyrrol-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
4-[4-(6-methoxynaphthalen-2-yl)-2-(2-phenylpropan-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
4-[4-(6-methoxynaphthalen-2-yl)-2-methyl-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.025
4-[4-(6-methoxynaphthalen-2-yl)-2-phenyl-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.000219
5-(2-methoxyethyl)-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000066
5-(3-methylbutyl)-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000007
5-(but-3-en-1-yl)-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000663
5-benzyl-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000456
5-cyclopropyl-9-(pyridin-2-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00017
5-methyl-9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.025
5-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyrimidine
Mycobacterium tuberculosis
-
above, pH and temperature not specified in the publication
0.000084
5-[3-(dimethylamino)propyl]-9-(3-methoxyphenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000857
5-[3-(dimethylamino)propyl]-9-(pyridin-2-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000131
5-[3-(dimethylamino)propyl]-9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0019
5-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0025 - 0.0088
5-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenol
0.0048
5-[6-iodo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenol
Mycobacterium tuberculosis
-
-
0.0058
6-bromo-N-butyl-2-[4-[2-(dimethylamino)ethoxy]phenyl]imidazo[1,2-a]pyridin-3-amine
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00061
9-(3-chlorophenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000051
9-(3-methoxyphenyl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000031
9-(pyridin-3-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.007
9-(quinolin-5-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00003
9-bromo-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000031
9-phenyl-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000333
9-phenyl-5-(prop-2-en-1-yl)-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.244
benzylethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
3
L-methionine S-sulfoximine
Mycobacterium tuberculosis
-
IC50: 3 mM
0.081
L-methionine sulfoximine
Mycobacterium tuberculosis
pH 7.5, 22°C
0.051
L-methionine-(S)-sulfoximine
Mycobacterium tuberculosis
pH 7.5, 22°C
0.1 - 26
L-methionine-S-sulfoximine
0.0207 - 0.051
methionine sulfoximine
0.231
N-(4-isopropylphenyl)aminomethylenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.249
N-(4-methylphenyl)aminoethalidenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0021
N-(4-oxo-5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-9-yl)acetamide
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.174
N-phenylaminoethalidenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.246
N-phenylaminomethylenebisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.2
Ni2+
Rattus norvegicus
-
pH 6.2, 37°C
0.221
phenylethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.348
phenylmethylidene-1-hydroxy-1,1-bisphosphonic acid
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0019 - 0.076
Phosphinothricin
0.186
[(2-chloro-3-methylphenyl)(hydroxy)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.358
[(2-chloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.317
[(3,4-dichloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.228
[(3,5-dichloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.269
[(3,5-difluoroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.227
[(3,5-dimethylanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.345
[(3,5-dimethylphenyl)(hydroxy)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.273
[(3-carbamoylanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.24
[(3-chloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.25
[(4-benzylanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.363
[(4-benzylphenyl)(hydroxy)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.375
[(4-chloroanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.525
[(4-methylanilino)methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.178
[2-(2,3-dichlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.18
[2-(2,6-dichloroanilino)ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.194
[2-(2,6-dichlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.082
[2-(3,5-dichloroanilino)ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.45
[2-(3,5-dimethylphenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.286
[2-(4-benzylanilino)ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.13
[2-(4-chlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.294
[2-[(5,6,7,8-tetrahydronaphthalen-1-yl)amino]ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.168
[2-[3,5-bis(trifluoromethyl)anilino]ethane-1,1-diyl]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0132
[3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]phenyl]methanol
Mycobacterium tuberculosis
-
-
0.0016
[4-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenoxy]acetic acid
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0128
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.286
[[(2,3-dihydro-1H-inden-5-yl)amino]methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.0212
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.015
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.0076
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.021
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
Zea mays
-
0.278
[[(5,6,7,8-tetrahydronaphthalen-2-yl)amino]methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
0.256
[[3-(trifluoromethyl)anilino]methylene]bis(phosphonic acid)
Mycobacterium tuberculosis
pH 7.5, 22°C
additional information
additional information
-
0.00038
3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]benzoic acid
Mycobacterium tuberculosis
-
-
0.00038
3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]benzoic acid
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0033
3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]phenol
Mycobacterium tuberculosis
-
-
0.0033
3-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]phenol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0031
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.0031
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0025
5-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenol
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0088
5-[6-bromo-3-(cyclopentylamino)imidazo[1,2-a]pyridin-2-yl]-2-methoxyphenol
Mycobacterium tuberculosis
-
-
0.2
AMP
Bacillus subtilis
-
mutant P306A, 25°C, pH not specified in the publication
0.5
AMP
Bacillus subtilis
-
wild-type, 25°C, pH not specified in the publication
1
AMP
Bacillus subtilis
-
mutant Y303H, 25°C, pH not specified in the publication
1.3
AMP
Bacillus subtilis
-
mutant Y303A, 25°C, pH not specified in the publication
1.4
AMP
Bacillus subtilis
-
mutant V300A, 25°C, pH not specified in the publication
1.5
AMP
Bacillus subtilis
-
mutant Y303L, 25°C, pH not specified in the publication
1.7
AMP
Bacillus subtilis
-
mutant E304D, 25°C, pH not specified in the publication
1.7
AMP
Bacillus subtilis
-
mutant G302A, 25°C, pH not specified in the publication
2.1
AMP
Bacillus subtilis
-
mutant A305G, 25°C, pH not specified in the publication
30
AMP
Bacillus subtilis
-
mutant E304A, 25°C, pH not specified in the publication
31
glycine
Bacillus subtilis
-
wild-type, 25°C, pH not specified in the publication
350
glycine
Bacillus subtilis
-
mutant A305G, 25°C, pH not specified in the publication
1.5
L-glutamine
Bacillus subtilis
-
mutant P306A, 25°C, pH not specified in the publication
2.4
L-glutamine
Bacillus subtilis
-
wild-type, 25°C, pH not specified in the publication
4.1
L-glutamine
Bacillus subtilis
-
mutant Y303H, 25°C, pH not specified in the publication
7
L-glutamine
Bacillus subtilis
-
mutant V300A, 25°C, pH not specified in the publication
11
L-glutamine
Bacillus subtilis
-
mutant G302A, 25°C, pH not specified in the publication
13
L-glutamine
Bacillus subtilis
-
mutant Y303A, 25°C, pH not specified in the publication
19
L-glutamine
Bacillus subtilis
-
mutant Y303L, 25°C, pH not specified in the publication
79
L-glutamine
Bacillus subtilis
-
mutant E304D, 25°C, pH not specified in the publication
140
L-glutamine
Bacillus subtilis
-
mutant A305G, 25°C, pH not specified in the publication
140
L-glutamine
Bacillus subtilis
-
mutant E304A, 25°C, pH not specified in the publication
0.1
L-methionine-S-sulfoximine
Bacillus subtilis
-
mutant Y303H, 25°C, pH not specified in the publication
0.1
L-methionine-S-sulfoximine
Bacillus subtilis
-
mutant Y303L, 25°C, pH not specified in the publication
0.104
L-methionine-S-sulfoximine
Mycobacterium tuberculosis
pH 7.5, 22°C, recombinant enzyme
0.12
L-methionine-S-sulfoximine
Bacillus subtilis
-
mutant V300A, 25°C, pH not specified in the publication
0.13
L-methionine-S-sulfoximine
Bacillus subtilis
-
wild-type, 25°C, pH not specified in the publication
0.25
L-methionine-S-sulfoximine
Bacillus subtilis
-
mutant P306A, 25°C, pH not specified in the publication
0.28
L-methionine-S-sulfoximine
Bacillus subtilis
-
mutant G302A, 25°C, pH not specified in the publication
0.61
L-methionine-S-sulfoximine
Bacillus subtilis
-
mutant Y303A, 25°C, pH not specified in the publication
2.7
L-methionine-S-sulfoximine
Bacillus subtilis
-
mutant A305G, 25°C, pH not specified in the publication
20
L-methionine-S-sulfoximine
Bacillus subtilis
-
mutant E304D, 25°C, pH not specified in the publication
26
L-methionine-S-sulfoximine
Bacillus subtilis
-
mutant E304A, 25°C, pH not specified in the publication
0.0207
methionine sulfoximine
Trypanosoma cruzi
recombinant enzyme, pH and temperature not specified in the publication
0.051
methionine sulfoximine
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0019
Phosphinothricin
Mycobacterium tuberculosis
pH 7.5, 22°C
0.076
Phosphinothricin
Mycobacterium tuberculosis
pH 7.5, 22°C
additional information
additional information
Mycobacterium tuberculosis
IC50 values of the compounds versus Mycobacterium tuberculosis cells and human Hep-G2 cells
-
additional information
additional information
Mycobacterium tuberculosis
-
IC50 values of the compounds versus Mycobacterium tuberculosis cells and human Hep-G2 cells
-