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6.3.1.2: glutamine synthetase

This is an abbreviated version!
For detailed information about glutamine synthetase, go to the full flat file.

Word Map on EC 6.3.1.2

Reaction

ATP
+
L-glutamate
 +
NH3
=
ADP
 +
phosphate
 +
L-glutamine

Synonyms

AmGLN1, ATP glutamate-ammonia ligase, Chloroplast GS2, Clone lambda-GS28, Clone lambda-GS31, Clone lambda-GS8, Cytoplasmic GS3, Cytosolic GS1, gamma-glutamyl transferase, gamma-glutamyl:ammonia ligase, gamma-glutamylhydroxamate synthetase, Gln isozyme alpha, Gln isozyme beta, Gln isozyme gamma, Gln synthetase, GLN1,1, GLN1,2, GLN1,3, GLN1,4, GLN1-1, GLN1-2, Gln1;1, Gln1;2, Gln1;3, Gln1;4, Gln1;5, GLN2, GlnA, glnA-1, GlnA1, GlnA2, GlnA3, GlnA4, GlnN, GlnR, GluA, GLUL, Glutamate--ammonia ligase, glutamate-ammonia ligase, Glutamine synthetase, glutamine synthetase cytosolic isozyme 1, glutamine synthetase cytosolic isozyme 2, glutamine synthetase I, glutamine synthetase type II, glutamine synthetase type III, Glutamylhydroxamic synthetase, GS, GS type I, GS type-1, GS(1), GS-II, GS1, GS1 kinase, GS1-1, GS1-2, GS107, GS112, GS117, GS12, GS122, GS1a, GS1beta1, GS1gamma1, GS2, GS2a, GS3, GSI, GSII, GSIII, Isozyme delta, L-glutamate:ammonia ligase, L-glutamate:ammonia ligase (ADP-forming), L-Glutamine synthetase, LDBPK_060370, LdGS, MM_0964, MtGS, N47/N48, OsGLN1,1, OsGLN1,2, protein transacetylase, S2205/S2287, SSO0366, Synthetase, glutamine, TAase, type I glutamine synthetase, type III glutamine synthetase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.2 glutamine synthetase

pH Optimum

pH Optimum on EC 6.3.1.2 - glutamine synthetase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
11
-
Mg2+-dependent reaction with ethylamine
5.2
-
isoenzyme GScl, Mn2+-activated enzyme
5.3
-
isoform GS1, Mn2+-activated enzyme
5.4
-
isoform GS2, Mn2+-activated enzyme
5.5
-
isoenzyme GScs, Mn2+-activated enzyme
5.5 - 6.5
-
transferase reaction
5.6
-
isozyme GSI, gamma-glutamylhydroxamate synthetase activity
6 - 6.5
6.2
glutamine synthesis
6.25
-
in the presence of Mn2+, at optimum pH values, moderately adenylated GS is twice more active in the presence of Mn2+ (at pH 6.25) than Mg2+ (at pH 8.0), whereas, at pH 7.1, which corresponds to the intracellular level of pH for the enzyme is almost equiactive with either cation
6.5 - 7
-
gamma-glutamyl transferase assay
6.8 - 7
-
GSIII-1 and GSIII-2 glutamine synthetase activity
6.9
-
adenylated enzyme, Mn2+-dependent activity
7.1 - 7.4
-
-
7.4 - 8
-
isoforms GSI and GSII
7.7
-
isoform GS1, Mg2+-activated enzyme
7.9
-
biosynthetic assay
8.2
-
isoform GS2, Mg2+-activated enzyme
8.3
-
enzyme form GSIII, biosynthetic assay
8.5
-
Mn2+-dependent reaction with ethylamine
additional information