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3.6.1.56: 2-hydroxy-dATP diphosphatase

This is an abbreviated version!
For detailed information about 2-hydroxy-dATP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.56

Reaction

2-hydroxy-dATP
+
H2O
=
2-hydroxy-dAMP
 +
diphosphate

Synonyms

(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, 8-oxo-dGTP hydrolase, hMTH1, MTH1, MTH2, MutT homologue 1, Nud2, Nudix hydrolase 2, NUDT1

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.56 2-hydroxy-dATP diphosphatase

Inhibitors

Inhibitors on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2Z)-2-methyl-4-[(9H-purin-6-yl)amino]but-2-en-1-ol
-
2'-deoxy-8-hydroxyguanosine 5'-triphosphate
-
-
2-(dimethylamino)-9-methyl-1,9-dihydro-6H-purin-6-one
-
2-amino-9-methyl-1,9-dihydro-6H-purin-6-one
-
2-amino-9-methyl-7,9-dihydro-1H-purine-6,8-dione
-
2-chloro-6-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)-9H-purine
-
2-hydroxy-dADP
-
competitively inhibits both the 2-hydroxy-dATP hydrolase and 8-hydroxy-dGTP hydrolase activities of hMTH1
2-hydroxy-dATP
the hydrolysis of 8-oxo-dGTP (0.01 mM) by wild type and F27A decreases to 42% and 44% of the control in the presence of 0.01 mM 2-hydroxy-dATP. 8-oxo-dGTPase activities of D119A and D119N mutants are not altered in the presence of 2-hydroxy-dATP up to 0.1 mM
2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
i.e. SCH-51344
3-[(2-amino-6-methylpyrimidin-4-yl)oxy]propan-1-ol
-
6-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)-9H-purine
-
6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
6-(methylamino)pyrimidine-2,4(1H,3H)-dione
-
8-oxo-dADP
-
-
8-oxo-dGDP
-
competitively inhibits both the 2-hydroxy-dATP hydrolase and 8-hydroxy-dGTP hydrolase activities of hMTH1
8-oxo-dGTP
9-methyl-2-(methylamino)-1,9-dihydro-6H-purin-6-one
-
dATP
the 8-oxo-dGTPase activity of wild type hMTH1 decreases to 79.6% of the control in the presence of 0.1 mM dATP
N-(1-methyl-1H-benzimidazol-5-yl)acetamide
-
N-(2-phenylethyl)-9H-purin-6-amine
-
N-[(2H-1,3-benzodioxol-5-yl)methyl]-9H-purin-6-amine
-
N-[(furan-2-yl)methyl]-9-methyl-9H-purin-6-amine
-
N-[(furan-2-yl)methyl]-9H-purin-6-amine
-
N-[3-[(propan-2-yl)oxy]propyl]-9H-purin-6-amine
NPD15095, competitive inhibition
N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine
N6-(2-methoxyethyl)-9H-purine-2,6-diamine
-
N6-(2-phenylethyl)-9H-purine-2,6-diamine
-
N6-benzyl-9H-purine-2,6-diamine
-
N6-[2-(3,4-dimethoxyphenyl)ethyl]-9H-purine-2,6-diamine
-
N6-[3-[(propan-2-yl)oxy]propyl]-9H-purine-2,6-diamine
-
TH1579
-