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3.6.1.56: 2-hydroxy-dATP diphosphatase

This is an abbreviated version!
For detailed information about 2-hydroxy-dATP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.56

Reaction

2-hydroxy-dATP
+
H2O
=
2-hydroxy-dAMP
 +
diphosphate

Synonyms

(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, 8-oxo-dGTP hydrolase, hMTH1, MTH1, MTH2, MutT homologue 1, Nud2, Nudix hydrolase 2, NUDT1

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.56 2-hydroxy-dATP diphosphatase

KCat KM Value

KCat KM Value on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1093
2-hydroxy-ATP
-
pH 8.0, 30°C
0.00168 - 3300
2-hydroxy-dATP
1.1 - 4.1
2-oxo-dATP
22
8-oxo-ATP
-
pH 8.0, 30°C
3.5 - 780
8-oxo-dATP
10.2
8-oxo-dGDP
-
in the presence of 1 mM Mn2+, at pH 8.0 and 37°C
0.1 - 1710
8-oxo-dGTP
47
8-oxo-GTP
-
pH 8.0, 30°C
0.09
ADP
-
in the presence of 5 mM Mn2+, at pH 8.0 and 37°C
0.27
Ap4A
-
in the presence of 5 mM Mn2+, at pH 8.0 and 37°C
3.5
ATP
-
in the presence of 5 mM Mn2+, at pH 8.0 and 37°C
3.2
dADP
-
in the presence of 5 mM Mg2+, at pH 8.0 and 37°C
5
dATP
-
in the presence of 5 mM Mn2+, at pH 8.0 and 37°C
0.95
dGDP
-
in the presence of 5 mM Mg2+, at pH 8.0 and 37°C
6 - 60
dGTP
5.8
GDP
-
in the presence of 5 mM Mn2+, at pH 8.0 and 37°C
0.6
GTP
-
in the presence of 5 mM Mn2+, at pH 8.0 and 37°C