Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.6.1.56: 2-hydroxy-dATP diphosphatase

This is an abbreviated version!
For detailed information about 2-hydroxy-dATP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.56

Reaction

2-hydroxy-dATP
+
H2O
=
2-hydroxy-dAMP
 +
diphosphate

Synonyms

(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, 8-oxo-dGTP hydrolase, hMTH1, MTH1, MTH2, MutT homologue 1, Nud2, Nudix hydrolase 2, NUDT1

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.56 2-hydroxy-dATP diphosphatase

Cloned

Cloned on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
both types of MTH1 protein (Met83-MTH1 and Val83-MTH1) are expressed in Escherichia coli mutT- cells
-
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli Gold BL21(DE3) cells
expressed in Escherichia coli mutT2 mutant cells devoid of their own 8-oxo-dGTPase activity
expression in Escherichia coli. Expression of cDNA for mMTH2 reduces significantly the elevated level of spontaneous mutation frequency of Escherichia coli mutT(-) cells
the increase in the production of erroneous proteins by oxidative damage is 28fold over the wild-type cells in Escherichia coli mutT deficient cells. By the expression of MTH1 in the cells, it is reduced to 1.2fold
-
when the human cDNA is expressed in Escherichia coli mutT- mutant cells, there is a significant amount of 8-oxo-dGTPase activity