3.6.1.56: 2-hydroxy-dATP diphosphatase
This is an abbreviated version!
For detailed information about 2-hydroxy-dATP diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.56
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3.6.1.56
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mutt
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triphosphates
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glycosylase
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8-oxo-dg
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sanitization
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8-oxo-2'-deoxyguanosine
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8-oxodgtp
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8-oxo-dgtpase
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dgtp
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hnpcc
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2-oh-datp
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8-ohdg
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8-hydroxy-2'-deoxyguanosine
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medicine
- 3.6.1.56
-
mutt
- triphosphates
- glycosylase
-
8-oxo-dg
-
sanitization
- 8-oxo-2'-deoxyguanosine
- 8-oxodgtp
- 8-oxo-dgtpase
- dgtp
-
hnpcc
-
2-oh-datp
-
8-ohdg
-
8-hydroxy-2'-deoxyguanosine
- medicine
Reaction
Synonyms
(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, 8-oxo-dGTP hydrolase, hMTH1, MTH1, MTH2, MutT homologue 1, Nud2, Nudix hydrolase 2, NUDT1
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Temperature Stability
Temperature Stability on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase
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55
60
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5 min, Met83-MTH1 loses 31-46% of its activity, Val83-MTH1 retains full activity
65
Tm-value for wild-type enzyme. 10 min, wild type hMTH1 retains 49% of the activity in the untreated extracts, mutant enzyme L150A retains 14% of the activity in the untreated extracts
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10 min, both types of MTH1 protein (Met83-MTH1 and Val83-MTH1) retain full activity until the temperature reaches 55°C
55
10 min, wild type hMTH1 retains 94% of the activity in the untreated extracts, mutant enzyme L150A retains 26% of the activity in the untreated extracts