3.6.1.56: 2-hydroxy-dATP diphosphatase

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For detailed information about 2-hydroxy-dATP diphosphatase, go to the full flat file.

Reaction

Synonyms

(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, 8-oxo-dGTP hydrolase, hMTH1, MTH1, MTH2, MutT homologue 1, Nud2, Nudix hydrolase 2, NUDT1

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.56 2-hydroxy-dATP diphosphatase

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2851	AA Sequence
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9	Cloned(Commentary)
4	Crystallization (Commentary)
186	Disease/ Diagnostics
6	Expression
10	General Information
40	IC50 Value
38	Inhibitors
38	kcat/KM [mM/s]
6	Ki Value [mM]
49	KM Value [mM]
3	Metals/Ions
3	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
29	Organism
141	PDB ID
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2	pH Range
22	Protein Variants
8	Purification (Commentary)
1	Reaction
29	Reference
22	Source Tissue
95	Substrates and Products (Substrate)
3	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
6	Temperature Stability [°C]
37	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

sitting drop vapor diffusion method, using 100 mM sodium acetate (pH 3.5), 200 mM Li2SO4, 0.5% (w/v) noctyl beta-D-glucoside, and 34% (w/v) PEG 6000

Canis lupus familiaris

F1P963

756056

enzyme in complex with substrates, hanging drop vapor diffusion method, using 25% (w/v) PEG3350 as precipitant

Homo sapiens

P36639

758131

in complex with 8-oxo-dGTPor 2-oxo-dATP, using 1.0 M sodium citrate, 0.1 M Tris-HCl, pH 7.0, and 0.2 M NaCl, or 1.0 M sodium citrate, 0.1 M cacodylate-HCl, pH 6.5, and 0.2 M NaCl

Homo sapiens

-

757187

in complex with inhibitor TH588, sitting drop vapor diffusion method, using 200 mM potassium thiocyanate and 20% (w/v) PEG 3350. In complex with substrate 8-oxo-dGTP, sitting drop vapor diffusion method, using 200 mM ammonium nitrate, 34% (w/v) PEG 3350, and 10 mM copper(II) chloride dihydrate

Mus musculus

P53368

756056