3.6.1.56: 2-hydroxy-dATP diphosphatase

This is an abbreviated version!
For detailed information about 2-hydroxy-dATP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.56

3.6.1.56

mutt

triphosphates

glycosylase

8-oxo-dg

sanitization

8-oxo-2'-deoxyguanosine

8-oxodgtp

8-oxo-dgtpase

dgtp

hnpcc

2-oh-datp

8-ohdg

8-hydroxy-2'-deoxyguanosine

medicine

Reaction

Synonyms

(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, 8-oxo-dGTP hydrolase, hMTH1, MTH1, MTH2, MutT homologue 1, Nud2, Nudix hydrolase 2, NUDT1

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.56 2-hydroxy-dATP diphosphatase

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Results	in table
2851	AA Sequence
2	Application
9	Cloned(Commentary)
4	Crystallization (Commentary)
186	Disease/ Diagnostics
6	Expression
10	General Information
40	IC50 Value
38	Inhibitors
38	kcat/KM [mM/s]
6	Ki Value [mM]
49	KM Value [mM]
3	Metals/Ions
3	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
29	Organism
141	PDB ID
6	pH Optimum
2	pH Range
22	Protein Variants
8	Purification (Commentary)
1	Reaction
29	Reference
22	Source Tissue
95	Substrates and Products (Substrate)
3	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
6	Temperature Stability [°C]
37	Turnover Number [1/s]

Expression

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Expression on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase

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a statistically significant induction of 8-oxo-dGTPase by 137Cs gamma radiation (given as a single whole-body dose (1 Gy/min)) is found in brains, testes and kidneys but not in lungs, hearts or livers

Mus musculus

716889

age-related accumulation of 8-oxoguanine in RNA is correlated with decreased expression of MTH1

2 entries

increased amounts of 8-oxoguanine in the RNA, and decreased expression of MTH1 are observed in the hippocampi of patients suffering from Alzheimer's disease

Homo sapiens

716343

oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction

2 entries