3.6.1.56: 2-hydroxy-dATP diphosphatase

This is an abbreviated version!
For detailed information about 2-hydroxy-dATP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.56

3.6.1.56

mutt

triphosphates

glycosylase

8-oxo-dg

sanitization

8-oxo-2'-deoxyguanosine

8-oxodgtp

8-oxo-dgtpase

dgtp

hnpcc

2-oh-datp

8-ohdg

8-hydroxy-2'-deoxyguanosine

medicine

Reaction

Synonyms

(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, 8-oxo-dGTP hydrolase, hMTH1, MTH1, MTH2, MutT homologue 1, Nud2, Nudix hydrolase 2, NUDT1

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.56 2-hydroxy-dATP diphosphatase

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Results	in table
2851	AA Sequence
2	Application
9	Cloned(Commentary)
4	Crystallization (Commentary)
186	Disease/ Diagnostics
6	Expression
10	General Information
40	IC50 Value
38	Inhibitors
38	kcat/KM [mM/s]
6	Ki Value [mM]
49	KM Value [mM]
3	Metals/Ions
3	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
29	Organism
141	PDB ID
6	pH Optimum
2	pH Range
22	Protein Variants
8	Purification (Commentary)
1	Reaction
29	Reference
22	Source Tissue
95	Substrates and Products (Substrate)
3	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
6	Temperature Stability [°C]
37	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase

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0.014 - 0.022

(2Z)-2-methyl-4-[(9H-purin-6-yl)amino]but-2-en-1-ol

2 entries

0.1

2-(dimethylamino)-9-methyl-1,9-dihydro-6H-purin-6-one

Homo sapiens

P36639

IC50 above 0.1 mM, pH and temperature not specified in the publication

758131

0.1

2-amino-9-methyl-1,9-dihydro-6H-purin-6-one

Homo sapiens

P36639

IC50 above 0.1 mM, pH and temperature not specified in the publication

758131

0.1

2-amino-9-methyl-7,9-dihydro-1H-purine-6,8-dione

Homo sapiens

P36639

IC50 above 0.1 mM, pH and temperature not specified in the publication

758131

0.00023 - 0.00035

2-chloro-6-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)-9H-purine

2 entries

0.0045

3-[(2-amino-6-methylpyrimidin-4-yl)oxy]propan-1-ol

Homo sapiens

P36639

pH and temperature not specified in the publication

758131

0.00021 - 0.00038

6-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)-9H-purine

2 entries

0.0015

6-(methylamino)pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P36639

pH and temperature not specified in the publication

758131

0.059

9-methyl-2-(methylamino)-1,9-dihydro-6H-purin-6-one

Homo sapiens

P36639

pH and temperature not specified in the publication

758131

0.08

N-(1-methyl-1H-benzimidazol-5-yl)acetamide

Homo sapiens

P36639

IC50 above 0.01 mM, pH and temperature not specified in the publication

758131

0.0028 - 0.0039

N-(2-phenylethyl)-9H-purin-6-amine

2 entries

0.02 - 0.028

N-[(2H-1,3-benzodioxol-5-yl)methyl]-9H-purin-6-amine

2 entries

N-[(furan-2-yl)methyl]-9-methyl-9H-purin-6-amine

Homo sapiens

P36639

IC50 above 1.0 mM, with 8-oxo-dGTP as substrate, at pH 7.5, temperature not specified in the publication

756426

0.02 - 0.029

N-[(furan-2-yl)methyl]-9H-purin-6-amine

2 entries

0.00333 - 0.0067

N-[3-[(propan-2-yl)oxy]propyl]-9H-purin-6-amine

2 entries

0.000004 - 0.000138

N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine

5 entries

0.0048 - 0.0091

N6-(2-methoxyethyl)-9H-purine-2,6-diamine

2 entries

0.00029 - 0.0005

N6-(2-phenylethyl)-9H-purine-2,6-diamine

2 entries

0.00063 - 0.00113

N6-benzyl-9H-purine-2,6-diamine

2 entries

0.00042 - 0.021

N6-[2-(3,4-dimethoxyphenyl)ethyl]-9H-purine-2,6-diamine

2 entries

0.0019 - 0.0028

N6-[3-[(propan-2-yl)oxy]propyl]-9H-purine-2,6-diamine

2 entries

0.0000022 - 0.000132

TH1579

3 entries