3.6.1.56: 2-hydroxy-dATP diphosphatase

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For detailed information about 2-hydroxy-dATP diphosphatase, go to the full flat file.

Reaction

Synonyms

(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, 8-oxo-dGTP hydrolase, hMTH1, MTH1, MTH2, MutT homologue 1, Nud2, Nudix hydrolase 2, NUDT1

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.56 2-hydroxy-dATP diphosphatase

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2851	AA Sequence
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9	Cloned(Commentary)
4	Crystallization (Commentary)
186	Disease/ Diagnostics
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10	General Information
40	IC50 Value
38	Inhibitors
38	kcat/KM [mM/s]
6	Ki Value [mM]
49	KM Value [mM]
3	Metals/Ions
3	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
29	Organism
141	PDB ID
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2	pH Range
22	Protein Variants
8	Purification (Commentary)
1	Reaction
29	Reference
22	Source Tissue
95	Substrates and Products (Substrate)
3	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
6	Temperature Stability [°C]
37	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Co2+

Myxococcus xanthus

-

Co2+ (5 mM) stimulates most enzyme hydrolase activities, with the exception of 8-oxo-dATP and Ap4A

757347

Mg2+

Myxococcus xanthus

-

5 mm Mg2+ is not effective in stimulating enzyme-mediated 8-oxo-dATP, ATP, and Ap4A hydrolysis, however, 5 mM Mg2+ is the most effective in hydrolysing dADP and dGDP

757347

Mn2+

Myxococcus xanthus

-

most effective cofactor. The optimal concentrations of Mn2+ for enzyme activity toward 8-oxo-dGTP and dGTP are 0.25 mM and 0.75 mM, respectively

757347