3.5.3.18: dimethylargininase
This is an abbreviated version!
For detailed information about dimethylargininase, go to the full flat file.
Word Map on EC 3.5.3.18
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3.5.3.18
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endothelial
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cardiovascular
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artery
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hypertension
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angiotensin
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l-citrulline
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aortic
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umbilical
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vasodilation
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vein
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endothelium-dependent
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dimethylamine
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atherosclerosis
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coronary
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methylarginines
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ng,ng-dimethylarginine
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homocysteine
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medicine
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huvecs
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endothelium-derived
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hyperhomocysteinemia
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nnos
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l-nmma
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ii-induced
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ng-monomethyl-l-arginine
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monomethylarginine
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ox-ldl
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analysis
- 3.5.3.18
- endothelial
- cardiovascular
- artery
- hypertension
- angiotensin
- l-citrulline
- aortic
-
umbilical
-
vasodilation
- vein
-
endothelium-dependent
- dimethylamine
- atherosclerosis
- coronary
-
methylarginines
- ng,ng-dimethylarginine
- homocysteine
- medicine
- huvecs
-
endothelium-derived
- hyperhomocysteinemia
- nnos
-
l-nmma
-
ii-induced
- ng-monomethyl-l-arginine
-
monomethylarginine
-
ox-ldl
- analysis
Reaction
Synonyms
Adv-DDAH, DDAH, DDAH-1, DDAH-2, DDAH-I, DDAH1, DDAH2, DDAHI, DDAHII, dimethlarginine dimethylaminohydrolase, dimethylaminohydrolase, Dimethylargininase, dimethylarginine dimethylamino-hydrolase, dimethylarginine dimethylaminohydrolase, dimethylarginine dimethylaminohydrolase 1, dimethylarginine dimethylaminohydrolase isoform 1, dimethylarginine dimethylaminohydrolase-2, dimethylarginine dimethylaminohydrolase1, dimethylarginine-dimethylaminohydrolase, G6a, hDDAH-1, human DDAH-1, human dimethylarginine dimethylaminohydrolase-1, Nomega,Nomega-dimethyl-L-arginine dimethylaminohydrolase-1, PA1195, PaDDAH
ECTree
3.5.3.18 dimethylargininaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.5.3.18 - dimethylargininase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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both DDAHI and DDAHII proteins are detected in peri-infarct cardiomyocytes, while DDAHII immunoreactivity is additionally localized to infiltrating inflammatory cells and blood vessels in the healing infarct. Both plasma and left ventricular concentrations of the DDAH substrate, ADMA, are increased post-myocardial infarction
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DDAH-2 protein expression is higher in osteoarthritic cartilage than in normal cartilage
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in healthy hearts, DDAHI is absent, and DDAHII is localized to endothelium and endocardium with a similar distribution to that of eNOS
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DDAHII immunoreactivity is localized to infiltrating inflammatory cells and blood vessels in the healing infarct
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both DDAH1 and 2 are expressed in the developing limb buds in patterns overlapping areas with high nitric oxide synthase activity
additional information
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DDAHII immunoreactivity is localized to infiltrating inflammatory cells and blood vessels in the healing infarct
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entire ventricular zone and tegmentum, ciliarly ganglion, inferior olive, interpeduncular nucleus, red nucleus, dorsal tegmental nucleus and nuclues of the lateral lemniscus
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coronary microvessels, arteries and veins, strong staining
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in healthy hearts, DDAHI is absent, and DDAHII is localized to endothelium and endocardium with a similar distribution to that of eNOS
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DDAH1 RNA is expressed in the left ventricle, cardiac outflow tract and developing vasculature. DDAH2 expression is seen in the developing left ventricle and cardiac outflow tract, and additionally in the peripheral nervous system
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in healthy hearts, DDAHI is absent, and DDAHII is localized to endothelium and endocardium with a similar distribution to that of eNOS
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in the serosa of and in the boundary between the smooth muscle and submucosa
expression of mRNA for DDAH-1 is 7fold higher in the liver compared to DDAH-2
expression of mRNA for DDAH-1 is 2fold higher in the renal cortex compared to DDAH-2
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DDAH-1 mRNA expression is especially strong in the ventral horn and dorsal root ganglion, and also localized in cervical, thoracic and lumbar spinal cord and sympathetic ganglion
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in the gray matter, especially in the ventral portion and sympathetic ganglion
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overexpression in the immortalized cell line
additional information
DDAH I predominates in tissues that express neuronal nitric oxide synthase, DDAH II predominates in tissues expressing endothelial nitric oxide synthase
additional information
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DDAH I predominates in tissues that express neuronal nitric oxide synthase, DDAH II predominates in tissues expressing endothelial nitric oxide synthase
