3.5.3.18: dimethylargininase

This is an abbreviated version!
For detailed information about dimethylargininase, go to the full flat file.

Reaction

Synonyms

Adv-DDAH, DDAH, DDAH-1, DDAH-2, DDAH-I, DDAH1, DDAH2, DDAHI, DDAHII, dimethlarginine dimethylaminohydrolase, dimethylaminohydrolase, Dimethylargininase, dimethylarginine dimethylamino-hydrolase, dimethylarginine dimethylaminohydrolase, dimethylarginine dimethylaminohydrolase 1, dimethylarginine dimethylaminohydrolase isoform 1, dimethylarginine dimethylaminohydrolase-2, dimethylarginine dimethylaminohydrolase1, dimethylarginine-dimethylaminohydrolase, G6a, hDDAH-1, human DDAH-1, human dimethylarginine dimethylaminohydrolase-1, Nomega,Nomega-dimethyl-L-arginine dimethylaminohydrolase-1, PA1195, PaDDAH

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.3 In linear amidines

                3.5.3.18 dimethylargininase

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Results	in table
47	Activating Compound
2707	AA Sequence
30	Application
1	CAS Registry Number
19	Cloned(Commentary)
3	Crystallization (Commentary)
778	Disease/ Diagnostics
8	Expression
12	General Information
1	General Stability
20	IC50 Value
138	Inhibitors
8	kcat/KM [mM/s]
26	Ki Value [mM]
34	KM Value [mM]
6	Localization
3	Metals/Ions
18	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
92	Organism
37	PDB ID
11	pH Optimum
2	pH Range
2	pH Stability
29	Protein Variants
12	Purification (Commentary)
1	Reaction
6	Reaction Type
88	Reference
3	Renatured (Commentary)
165	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
92	Substrates and Products (Substrate)
7	Subunits
138	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
3	Temperature Stability [°C]
20	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.5.3.18 - dimethylargininase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

9 entries

NG,NG-dimethyl-L-arginine + H2O

L-citrulline + dimethylamine

Rattus norvegicus

-

-

669780

-

-

?

Nomega,Nomega'-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Homo sapiens

O94760

-

734539, 735071

-

-

?

additional information

?

-

Homo sapiens

-

DDAH1 forms a protein complex with Ras

718717

-

-

?

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Bos taurus

-

enzyme is involved in regulation of the levels of the natural occuring free arginine derivatives L-Nomega,Nomega-dimethylarginine and L-Nomega-methylarginine, which are reversible inhibitors of nitric oxide synthase

288969

-

-

?

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Homo sapiens

-

the key role of dimethylarginine dimethylaminohydrolase may be to ensure that under normal conditions the levels of methylarginines are kept low throughout the whole cell

288968

-

-

?

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Homo sapiens

-

enzyme plays an integral role in arginine handling

288967

-

-

?

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Homo sapiens

-

the enzyme plays a functional role in the regulation of nitric oxide synthase

288970

-

-

?

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Homo sapiens

-

the enzyme might play a role as a regulator of nitric oxide generation in human tissues

288972

-

-

?

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Mus musculus

-

enzyme plays an integral role in arginine handling

288967

-

-

?

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Rattus norvegicus

-

enzyme plays an integral role in arginine handling

288967

-

-

?

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Rattus norvegicus

-

enzyme plays a role in metabolism of NG,NG-dimethyl-L-arginine

288971

-

-

?

NG,NG-dimethyl-L-arginine + H2O

dimethylamine + L-citrulline

Rattus norvegicus

-

the enzyme plays a functional role in the regulation of nitric oxide synthase

288970

-

-

?