Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | probucol and the intracellular antioxidant pyrrolidine dithiocarbamate significantly attenuate inhibition of endothelial DDAH activity by oxidized-low density lipoprotein or lysophosphatidylcholine, but probucol or PDTC itself had no effect on the activity of DDAH | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | protective effect of probucol on endothelium related to enhancement of DDAH activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lysophosphatidylcholine | - |
Homo sapiens | |
lysophosphatidylcholine | activity is significantly decreased in cells treated with lysophosphatidylcholine (0.005 mg/ml) for 48 h, 0.001-0.005 mM probucol or 0.001 mM pyrrolidindithiocarbamate significantly attenuate inhibition of DDAH activity by lysophosphatidylcholine | Rattus norvegicus | |
additional information | probucol or pyrrolidindithiocarbamate itself have no effect on the activity of DDAH | Rattus norvegicus | |
oxidized-low density lipoprotein | - |
Homo sapiens | |
oxidized-low density lipoprotein | activity is significantly decreased in cells treated with oxidized-low density lipoprotein (0.1 mg/ml) for 48 h, 0.001-0.005 mM probucol or 0.001 mM pyrrolidindithiocarbamat significantly attenuate inhibition of DDAH activity by oxidized-low density lipoprotein | Rattus norvegicus | |
sulfurosalicylic acid | inactivates DDAH | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | - |
Rattus norvegicus | - |
umbilical vein endothelial cell line | HUVEC-12 cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NG,NG-dimethyl-L-arginine + H2O | - |
Rattus norvegicus | dimethylamine + L-citrulline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DDAH | - |
Homo sapiens |
DDAH | - |
Rattus norvegicus |
dimethylarginine dimethylaminohydrolase | - |
Homo sapiens |
dimethylarginine dimethylaminohydrolase | - |
Rattus norvegicus |