3.5.3.18: dimethylargininase

This is an abbreviated version!
For detailed information about dimethylargininase, go to the full flat file.

Reaction

Synonyms

Adv-DDAH, DDAH, DDAH-1, DDAH-2, DDAH-I, DDAH1, DDAH2, DDAHI, DDAHII, dimethlarginine dimethylaminohydrolase, dimethylaminohydrolase, Dimethylargininase, dimethylarginine dimethylamino-hydrolase, dimethylarginine dimethylaminohydrolase, dimethylarginine dimethylaminohydrolase 1, dimethylarginine dimethylaminohydrolase isoform 1, dimethylarginine dimethylaminohydrolase-2, dimethylarginine dimethylaminohydrolase1, dimethylarginine-dimethylaminohydrolase, G6a, hDDAH-1, human DDAH-1, human dimethylarginine dimethylaminohydrolase-1, Nomega,Nomega-dimethyl-L-arginine dimethylaminohydrolase-1, PA1195, PaDDAH

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.3 In linear amidines

                3.5.3.18 dimethylargininase

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Results	in table
47	Activating Compound
2707	AA Sequence
30	Application
1	CAS Registry Number
19	Cloned(Commentary)
3	Crystallization (Commentary)
778	Disease/ Diagnostics
8	Expression
12	General Information
1	General Stability
20	IC50 Value
138	Inhibitors
8	kcat/KM [mM/s]
26	Ki Value [mM]
34	KM Value [mM]
6	Localization
3	Metals/Ions
18	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
92	Organism
37	PDB ID
11	pH Optimum
2	pH Range
2	pH Stability
29	Protein Variants
12	Purification (Commentary)
1	Reaction
6	Reaction Type
88	Reference
3	Renatured (Commentary)
165	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
92	Substrates and Products (Substrate)
7	Subunits
138	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
3	Temperature Stability [°C]
20	Turnover Number [1/s]

Expression

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Expression on EC 3.5.3.18 - dimethylargininase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

alpha-lipoic acid increases the gene expression and activity of DDAH, and signal transducer and activator of transcription STAT3 phosphorylation. Transfection of STAT3 increases DDAH II promoter activity, and alpha-lipoic acid amplifies it. alpha-Lipoic acid-induced increase in DDAH II promoter activity is attenuated in the promoter that has a mutation in the putative STAT3-binding site

Mus musculus

-

711109

DDAH isoforms are expressed in a dynamic,overlapping pattern during embryonic development

Mus musculus

-

712183

DDAH-2 protein expression is higher in osteoarthritic cartilage than in normal cartilage

Homo sapiens

-

718718

during growth on asymmetric dimethyl-L-arginine, induction of the DdaH gene is achieved via the putative enhancer-binding protein PA1196 and the alternative sigma factor RpoN. Both PA1196 and RpoN are essential for the expression of the DdaH gene in response to methylarginines

Pseudomonas aeruginosa

Q9I4E3

754016

following myocardial infarction, left ventricular DDAH activity is increased to 210% of control

Rattus norvegicus

-

710771

in chondrocyte mitochondria extracts, DDAH-2 expression is significantly increased after exposure to IL-1beta

Homo sapiens

-

718718

resveratrol activates silent information regulator SIRT1 and inhibits upregulates the expression of DDAH2

Homo sapiens

O95865

752652

treatment of mice with farnesoid X receptor agonist 3-(2,6-dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole, i.e. GW4064, leads to increased expression of DDAH-1 and cationic amino acid transporter CAT-1 in both liver and kidney

Mus musculus

-

712845