3.5.3.18: dimethylargininase
This is an abbreviated version!
For detailed information about dimethylargininase, go to the full flat file.
Word Map on EC 3.5.3.18
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3.5.3.18
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endothelial
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cardiovascular
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artery
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hypertension
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angiotensin
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l-citrulline
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aortic
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umbilical
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vasodilation
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vein
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endothelium-dependent
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dimethylamine
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atherosclerosis
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coronary
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methylarginines
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ng,ng-dimethylarginine
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homocysteine
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medicine
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huvecs
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endothelium-derived
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hyperhomocysteinemia
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nnos
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l-nmma
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ii-induced
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ng-monomethyl-l-arginine
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monomethylarginine
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ox-ldl
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analysis
- 3.5.3.18
- endothelial
- cardiovascular
- artery
- hypertension
- angiotensin
- l-citrulline
- aortic
-
umbilical
-
vasodilation
- vein
-
endothelium-dependent
- dimethylamine
- atherosclerosis
- coronary
-
methylarginines
- ng,ng-dimethylarginine
- homocysteine
- medicine
- huvecs
-
endothelium-derived
- hyperhomocysteinemia
- nnos
-
l-nmma
-
ii-induced
- ng-monomethyl-l-arginine
-
monomethylarginine
-
ox-ldl
- analysis
Reaction
Synonyms
Adv-DDAH, DDAH, DDAH-1, DDAH-2, DDAH-I, DDAH1, DDAH2, DDAHI, DDAHII, dimethlarginine dimethylaminohydrolase, dimethylaminohydrolase, Dimethylargininase, dimethylarginine dimethylamino-hydrolase, dimethylarginine dimethylaminohydrolase, dimethylarginine dimethylaminohydrolase 1, dimethylarginine dimethylaminohydrolase isoform 1, dimethylarginine dimethylaminohydrolase-2, dimethylarginine dimethylaminohydrolase1, dimethylarginine-dimethylaminohydrolase, G6a, hDDAH-1, human DDAH-1, human dimethylarginine dimethylaminohydrolase-1, Nomega,Nomega-dimethyl-L-arginine dimethylaminohydrolase-1, PA1195, PaDDAH
ECTree
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Crystallization
Crystallization on EC 3.5.3.18 - dimethylargininase
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by sitting drop vapor diffusion, at 1.08-2.0 A resolution and at pH 6.3 and pH 9.0
N5-(1-iminopropyl)-L-ornithine:DDAH-1 complex, to 1.9 A resolution, covalent bond formation between the inhibitors amidino carbon and the active-site Cys274, and solution studies show reversible competitive inhibition, consistent with a reversible covalent mode of DDAH inhibition by alkylamidine inhibitors
A 2.18 A resolution X-ray crystal structure of the inactivated complex elucidates the orientation of the inactivator and its covalent attachment to the active site Cys
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