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Literature summary for 3.5.3.18 extracted from
- Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease (2009), Expert. Opin. Drug Metab. Toxicol., 5, 303-319.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| adiponectin | - |
Homo sapiens | |
| all-trans-retinoic acid | 1.9fold increase in DDAH-2 mRNA and protein expression | Mus musculus |  |
| aminoguanidine | - |
Rattus norvegicus | |
| aspirin | - |
Rattus norvegicus | |
| EDTA | - |
Rattus norvegicus | |
| epigallocatechin gallate | - |
Homo sapiens | |
| fenofibrate | - |
Homo sapiens | |
| Insulin | - |
Homo sapiens | |
| interleukin-1beta | - |
Rattus norvegicus | |
| interleukin-1beta | 2fold increase in DDAH-1 protein expression | Rattus norvegicus | |
| losartan | - |
Homo sapiens | |
| nebivolol | 2fold increase in DDAH-2 mRNA and protein expression | Homo sapiens | |
| oestradiol | 60-70% increase in DDAH-2 mRNA and protein expression | Homo sapiens | |
| pioglitazone | 2-3fold increase of DDAH-2 mRNA and protein levels | Rattus norvegicus | |
| pravastatin | - |
Rattus norvegicus | |
| probucol | - |
Homo sapiens | |
| taurin | - |
Bos taurus | |
| taurin | - |
Rattus norvegicus | |
| taurin | - |
Homo sapiens | |
| taurine | - |
Oryctolagus cuniculus | |
| taurine | - |
Mus musculus | |
| telmisartan | - |
Bos taurus | |
| telmisartan | - |
Oryctolagus cuniculus | |
| telmisartan | - |
Rattus norvegicus | |
| telmisartan | - |
Mus musculus | |
| telmisartan | - |
Homo sapiens | |
| vitamin E | - |
Bos taurus | |
| vitamin E | - |
Oryctolagus cuniculus | |
| vitamin E | - |
Rattus norvegicus | |
| vitamin E | - |
Mus musculus | |
| vitamin E | - |
Homo sapiens | |
| xanthone | - |
Bos taurus | |
| xanthone | - |
Oryctolagus cuniculus | |
| xanthone | - |
Rattus norvegicus | |
| xanthone | - |
Mus musculus | |
| xanthone | - |
Homo sapiens | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Bos taurus |
| medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Oryctolagus cuniculus |
| medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Rattus norvegicus |
| medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Mus musculus |
| medicine | influence on atherosclerosis in experimental models by increased ADMA concentrations and reduced NO synthesis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-(N,N-dimethylamino)diazenolate-2-oxide | 1 mM, 50% inhibition of DDAH-1 | Homo sapiens | |
| 2-(N,N-dimethylamino)diazenolate-2-oxide | 1 mM, 50% inhibition of DDAH-1; 1 mM, 50% inhibition of DDAH-1 | Mus musculus | |
| 2-(N,N-dimethylamino)diazenolate-2-oxide | 1 mM, 50% inhibition of DDAH-1 | Rattus norvegicus | |
| 4-hydroxy-2-nonenal | 50 microM, 50% relative activity | Homo sapiens | |
| angiotensin II | 1 microM, about 55% relative activity; 1 microM, about 55% relative activity | Homo sapiens | |
| cytokine induced nitric-oxide synthesis | - |
Homo sapiens | |
| erythropoetin | 200 units/ml, about 75% relative activity; 200 units/ml, about 75% relative activity | Homo sapiens | |
| glucose | - |
Homo sapiens | |
| glucose | 25.5 mmol/l; 25.5 mmol/l | Mus musculus | |
| glucose | 25.5 mmol/l; 25.5 mmol/l | Rattus norvegicus | |
| glycosylated bovine serum albumin | - |
Rattus norvegicus | |
| homocysteine | - |
Homo sapiens | |
| hydrogen peroxide | 100 microM, 50% relative activity | Homo sapiens | |
| lipopolysaccharide | 1 microg/ml, 24 h, about 55% relative activity; 1 microg/ml, about 55% relative activity | Homo sapiens | |
| low-density-lipoprotein | 100 microg/ml | Homo sapiens | |
| lysophosphatidylcholine | 10 microg/ml, about 35% relative activity | Homo sapiens | |
| Mercuric chloride | - |
Rattus norvegicus | |
| N-(2-methoxyethyl)-L-arginine | complete inhibition at 100 microM; complete inhibition at 100 microM | Rattus norvegicus | |
| N-(2-methoxyethyl)arginine | - |
Mus musculus | |
| N-(2-methoxyethyl)arginine methyl esther | - |
Mus musculus | |
| N-nitro-L-arginine methylester | 1 mM, 1 h, 47.1% relative activity; 1mM, 1 h, 47.1% relative activity | Bos taurus | |
| N-nitro-L-arginine methylester | 1mM, 1 h, 47.1% relative activity | Homo sapiens | |
| N-nitro-L-arginine methylester | - |
Mus musculus | |
| N-nitro-L-arginine methylester | 1 mM, 1 h, 47.1% relative activity | Oryctolagus cuniculus | |
| N-nitro-L-arginine methylester | - |
Rattus norvegicus | |
| Nicotine | 50% decrease in DDAH-2 mRNA | Homo sapiens | |
| nitric oxide | increased NO production nitrosates DDAH | Homo sapiens | |
| nitroglycerine | 10 microM, 16 h, about 55% relative activity; 10 microM, about 55% relative activity | Homo sapiens | |
| peroxynitrite | - |
Homo sapiens | |
| S-2-amino-4-[N-(2-methoxyethyl)guanidino]butanoic acid benzyl ester | - |
Rattus norvegicus | |
| TNF-alpha | 250 U/ml, 63% relative activity | Homo sapiens | |
| Zn2+ | 20 microM, 40% relative activity; 20 microM, 40% relative activity | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.18 | - |
dimethyl-L-arginine | - |
Bos taurus | |
| 0.18 | - |
dimethyl-L-arginine | - |
Oryctolagus cuniculus | |
| 0.18 | - |
dimethyl-L-arginine | - |
Rattus norvegicus | |
| 0.18 | - |
dimethyl-L-arginine | - |
Mus musculus | |
| 0.18 | - |
dimethyl-L-arginine | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Bos taurus | Q3SX44 | - |
- |
| Homo sapiens | O94760 | - |
- |
| Homo sapiens | O95865 | - |
- |
| Mus musculus | Q99LD8 | - |
- |
| Mus musculus | Q9CWS0 | - |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | O08557 | - |
- |
| Rattus norvegicus | Q6MG60 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aortic endothelial cell | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| ECV304 cell | - |
Homo sapiens | - |
| endothelial cell | sEnd-1 cells | Mus musculus | - |
| heart | - |
Oryctolagus cuniculus | - |
| heart | - |
Rattus norvegicus | - |
| heart | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Bos taurus | - |
| HUVEC cell | - |
Homo sapiens | - |
| kidney | - |
Bos taurus | - |
| kidney | - |
Oryctolagus cuniculus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Bos taurus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| placenta | - |
Oryctolagus cuniculus | - |
| placenta | - |
Rattus norvegicus | - |
| placenta | - |
Mus musculus | - |
| placenta | - |
Homo sapiens | - |
| placenta | - |
Bos taurus | - |
| pulmonary artery endothelial cell | - |
Mus musculus | - |
| smooth muscle | - |
Rattus norvegicus | - |
| umbilical vein endothelial cell | - |
Homo sapiens | - |
| vascular endothelium | - |
Oryctolagus cuniculus | - |
| vascular endothelium | - |
Rattus norvegicus | - |
| vascular endothelium | - |
Mus musculus | - |
| vascular endothelium | - |
Homo sapiens | - |
| vascular endothelium | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dimethyl-L-arginine + H2O | - |
Bos taurus | L-citrulline + dimethylamine | - |
? | |
| dimethyl-L-arginine + H2O | - |
Oryctolagus cuniculus | L-citrulline + dimethylamine | - |
? | |
| dimethyl-L-arginine + H2O | - |
Rattus norvegicus | L-citrulline + dimethylamine | - |
? | |
| dimethyl-L-arginine + H2O | - |
Mus musculus | L-citrulline + dimethylamine | - |
? | |
| dimethyl-L-arginine + H2O | - |
Homo sapiens | L-citrulline + dimethylamine | - |
? | |
| Ngamma-monomethyl-L-arginine + H2O | - |
Bos taurus | L-citrulline + methylamine | - |
? | |
| Ngamma-monomethyl-L-arginine + H2O | - |
Oryctolagus cuniculus | L-citrulline + methylamine | - |
? | |
| Ngamma-monomethyl-L-arginine + H2O | - |
Rattus norvegicus | L-citrulline + methylamine | - |
? | |
| Ngamma-monomethyl-L-arginine + H2O | - |
Mus musculus | L-citrulline + methylamine | - |
? | |
| Ngamma-monomethyl-L-arginine + H2O | - |
Homo sapiens | L-citrulline + methylamine | - |
? | |
| S-methyl-L-thiocitrulline + H2O | - |
Bos taurus | L-citrulline + methanethiol | - |
? | |
| S-methyl-L-thiocitrulline + H2O | - |
Oryctolagus cuniculus | L-citrulline + methanethiol | - |
? | |
| S-methyl-L-thiocitrulline + H2O | - |
Rattus norvegicus | L-citrulline + methanethiol | - |
? | |
| S-methyl-L-thiocitrulline + H2O | - |
Mus musculus | L-citrulline + methanethiol | - |
? | |
| S-methyl-L-thiocitrulline + H2O | - |
Homo sapiens | L-citrulline + methanethiol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDAH-1 | - |
Bos taurus |
| DDAH-1 | - |
Oryctolagus cuniculus |
| DDAH-1 | - |
Mus musculus |
| DDAH-1 | - |
Rattus norvegicus |
| DDAH-1 | - |
Homo sapiens |
| DDAH-2 | - |
Oryctolagus cuniculus |
| DDAH-2 | - |
Rattus norvegicus |
| DDAH-2 | - |
Mus musculus |
| DDAH-2 | - |
Homo sapiens |
| DDAH-2 | - |
Bos taurus |
| dimethylarginine dimethylaminohydrolase | - |
Bos taurus |
| dimethylarginine dimethylaminohydrolase | - |
Oryctolagus cuniculus |
| dimethylarginine dimethylaminohydrolase | - |
Rattus norvegicus |
| dimethylarginine dimethylaminohydrolase | - |
Mus musculus |
| dimethylarginine dimethylaminohydrolase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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