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3.5.3.18: dimethylargininase

This is an abbreviated version!
For detailed information about dimethylargininase, go to the full flat file.

Word Map on EC 3.5.3.18

Reaction

Nomega,Nomega'-dimethyl-L-arginine
+
H2O
=
Dimethylamine
 +
L-citrulline

Synonyms

Adv-DDAH, DDAH, DDAH-1, DDAH-2, DDAH-I, DDAH1, DDAH2, DDAHI, DDAHII, dimethlarginine dimethylaminohydrolase, dimethylaminohydrolase, Dimethylargininase, dimethylarginine dimethylamino-hydrolase, dimethylarginine dimethylaminohydrolase, dimethylarginine dimethylaminohydrolase 1, dimethylarginine dimethylaminohydrolase isoform 1, dimethylarginine dimethylaminohydrolase-2, dimethylarginine dimethylaminohydrolase1, dimethylarginine-dimethylaminohydrolase, G6a, hDDAH-1, human DDAH-1, human dimethylarginine dimethylaminohydrolase-1, Nomega,Nomega-dimethyl-L-arginine dimethylaminohydrolase-1, PA1195, PaDDAH

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.3 In linear amidines
                3.5.3.18 dimethylargininase

KI Value

KI Value on EC 3.5.3.18 - dimethylargininase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.155
(2S)-2-amino-5-(ethanimidoylamino)pentanoic acid
-
pH 7.4, 37°C
0.09
(2S)-2-amino-5-(N'-butylcarbamimidamido)pentanoic acid
-
pH 7.4, 37°C
0.002
(2S)-2-amino-5-(pent-4-enimidoylamino)pentanoic acid
-
pH 7.4, 37°C
0.032
(2S)-2-amino-5-(pentanimidoylamino)pentanoic acid
-
pH 7.4, 37°C
0.145
(2S)-2-amino-5-(propanimidoylamino)pentanoic acid
-
pH 7.4, 37°C
0.036
(2S)-2-amino-5-[(4E)-hex-4-enimidoylamino]pentanoic acid
-
pH 7.4, 37°C
0.606
(2S)-2-amino-5-[N'-(3,3,3-trifluoropropyl)carbamimidamido]pentanoic acid
-
pH 7.4, 37°C
0.013
(2S)-2-amino-5-[N'-(3-methoxypropyl)carbamimidamido]pentanoic acid
-
pH 7.4, 37°C, inhibitor is selective over NOS and over arginase
0.764
(2S)-2-amino-5-[N'-(4-amino-4-oxobutyl)carbamimidamido]pentanoic acid
-
pH 7.4, 37°C
0.058
(2S)-2-amino-5-[N'-(but-3-en-1-yl)carbamimidamido]pentanoic acid
-
pH 7.4, 37°C
0.017
(2S)-2-amino-5-[N'-(but-3-yn-1-yl)carbamimidamido]pentanoic acid
-
pH 7.4, 37°C
1.968
(2S)-2-amino-5-[N'-(nitromethyl)carbamimidamido]pentanoic acid
-
pH 7.4, 37°C
0.057
(2S)-2-amino-5-[N'-(pent-4-en-1-yl)carbamimidamido]pentanoic acid
-
pH 7.4, 37°C
3.1
2-chloroacetamidine
-
0.4 - 4
L-lysine
0.057
N5-(but-3-en-1-ylcarbamimidoyl)-L-ornithine
-
-
0.058
N5-(prop-2-en-1-ylcarbamimidoyl)-L-ornithine
-
-
0.017
N5-(prop-2-yn-1-ylcarbamimidoyl)-L-ornithine
-
-
0.09
N5-(propylcarbamimidoyl)-L-ornithine
-
-
0.002
N5-but-3-enimidoyl-L-ornithine
-
-
0.032
N5-butanimidoyl-L-ornithine
-
-
0.145
N5-propanimidoyl-L-ornithine
-
-
0.013
N5-[(2-methoxyethyl)carbamimidoyl]-L-ornithine
-
-
0.036
N5-[(3E)-pent-3-enimidoyl]-L-ornithine
-
-
0.69
S-nitroso-L-homocysteine
in the presence of 5 mM EDTA, at pH 7.3 and 37°C