Literature summary for 3.5.3.18 extracted from

Scalera, F.; Kielstein, J.T.; Martens-Lobenhoffer, J.; Postel, S.C.; Tager, M.; Bode-Boger, S.M.
Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase (2005), J. Am. Soc. Nephrol., 16, 892-898.

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Application

Application	Comment	Organism
medicine	epoetin beta and darbepoetin alpha posttranslationally impair DDAH activity via increased oxidative stress, causing NG,NG-dimethyl-L-arginine as an important cardiovascular risk factor to accumulate and inhibit NO-synthesis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
darbepoetin alpha	inhibits DDAH in a dose dependent manner, inhibition of DDAH is abolished by incubation with EPO antibody or with antioxidant pyrrolidine dithiocarbamate	Homo sapiens
epoetin beta	inhibits DDAH in a dose dependent manner, inhibition of DDAH is abolished by incubation with EPO antibody or with antioxidant pyrrolidine dithiocarbamate	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
umbilical vein endothelial cell line	HUVEC cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NG,NG-dimethyl-L-arginine + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
DDAH	-	Homo sapiens
dimethylarginine dimethylaminohydrolase	-	Homo sapiens

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Release 2023.1 (January 2023)