3.4.24.B10: ADAM12 endopeptidase
This is an abbreviated version!
For detailed information about ADAM12 endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.B10
-
3.4.24.B10
-
adams
-
pregnancy
-
trimester
-
integrins
-
metalloproteinases
-
myoblasts
-
papp-a
-
pregnancy-associated
-
preeclampsia
-
first-trimester
-
ectodomain
-
thrombospondin
-
protein-a
-
hb-egf
-
egf-like
-
metalloprotease-disintegrins
-
gestation-specific
-
nuchal
-
disintegrin-like
-
timp-3
-
adamts-7
-
invadopodia
-
medicine
-
metalloproteinase-12
-
beta-hcg
-
prodomain
-
second-trimester
-
igfbp-5
- 3.4.24.B10
-
adams
- pregnancy
-
trimester
- integrins
- metalloproteinases
- myoblasts
- papp-a
-
pregnancy-associated
- preeclampsia
-
first-trimester
- ectodomain
- thrombospondin
- protein-a
- hb-egf
-
egf-like
-
metalloprotease-disintegrins
-
gestation-specific
-
nuchal
-
disintegrin-like
- timp-3
-
adamts-7
-
invadopodia
- medicine
-
metalloproteinase-12
-
beta-hcg
- prodomain
-
second-trimester
- igfbp-5
Reaction
proteolysis of proteins =
Synonyms
a disintegrin and metalloprotease 12, a disintegrin and metalloprotease with thrombospondin motifs 12, a disintegrin and metalloprotease-12, a disintegrin and metalloproteinase 12, a disintegrin and metalloproteinase domain 12, a disintegrin and metalloproteinase domain-containing protein 12, a disintegrin and metalloproteinase12, ADAM 12, ADAM 12-S, ADAM-12, ADAM-12m, ADAM-PCD, ADAM12, ADAM12-L, ADAM12-PC, ADAM12-S, ADAM12/meltrin alpha, ADAM12L, ADAM12S, ADAMTS-12, ADMA12L, basigin sheddase, disintegrin and metalloprotease 12, full-length ADAM 12-S, M12.212, meltrin alpha, meltrin-alpha, metalloprotease-disintegrin ADAM 12, metalloprotease-disintegrin ADAM12
ECTree
3.4.24.B10 ADAM12 endopeptidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.24.B10 - ADAM12 endopeptidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-Fam-FFLAQA(homophenylalanine)RSK-NH2 + H2O
5-Fam-FFLAQA + (homophenylalanine)RSK-NH2
best substrate
-
-
?
5-Fam-HADLAQA(homophenylalanine)RSK-NH2 + H2O
5-Fam-HADLAQA + (homophenylalanine)RSK-NH2
-
-
-
?
5-Fam-HALAQA(homophenylalanine)RSK-NH2 + H2O
5-Fam-HALAQA + (homophenylalanine)RSK-NH2
-
-
-
?
5-Fam-LAQA(homophenylalanine)RSK-NH2 + H2O
5-Fam-LAQA + (homophenylalanine)RSK-NH2
-
-
-
?
basigin + H2O
soluble basigin fragment + ?
the enzyme binds basigin and cleaves it in the juxta membrane region, thereby releasing a soluble basigin fragment to the extracellular space
-
-
?
dabcyl-LAQA(homo)PheRSK(5FAM)-NH2 + H2O
?
-
a 5-carboxamido-fluorescein labelled substrate
-
-
?
Dabcyl-LAQA(homophenylalanine)RSK(5-FAM)-NH2 + H2O
Dabcyl-LAQA + (homophenylalanine)RSK(5-FAM)-NH2
-
-
-
?
pro-heparin-binding-epidermal growth factor-like growth factor + H2O
?
-
-
-
-
?
insulin-like growth factor binding protein-3 + H2O
?
-
-
-
-
?
insulin-like growth factor binding protein-3 + H2O
?
-
-
-
?
insulin-like growth factor binding protein-3 + H2O
?
enzyme plays a role in degradation of insulin-like growth factor binding protein-3 in the blood of pregnant women
-
?
insulin-like growth factor binding protein-3 + H2O
?
in serum of pregnant women
-
?
protein + H2O
peptides
-
key enzyme in the ectodomain shedding of membrane-anchored heparin-binding epidermal growth factor, i.e. proHB-EGF, leading to epidermal growth factor-like receptor transactivation
-
?
additional information
?
-
enzyme complexes alpha2-macroglobulin
-
?
additional information
?
-
enzyme complexes alpha2-macroglobulin
-
?
additional information
?
-
no activity with insulin-like growth factor binding proteins-1, -2, -4 and -6
-
?
additional information
?
-
-
no activity with insulin-like growth factor binding proteins-1, -2, -4 and -6
-
?
additional information
?
-
-
ADAM12 prevents degradation of transforming growth factor-beta type II receptor
-
-
?
additional information
?
-
-
enzyme interacts with alpha-actinin-1 and skeletal muscle specific alpha-actinin-2 via its cytoplasmic domain, the interacation is responsible for the intracellular targeting of ADAM 12
-
?
additional information
?
-
-
enzyme provides docking sites for the Src homology 3 domain of p85alpha and thus activates PI 3-kinase by mediating its recruitment to the membrane
-
?
additional information
?
-
enzyme is a marker of skeletal muscle regeneration, binds to alpha-actinin-2 via a specific binding site, and is required for myoblast fusion
-
?
additional information
?
-
-
overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation
-
?
