3.4.24.B10: ADAM12 endopeptidase

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For detailed information about ADAM12 endopeptidase, go to the full flat file.

Reaction

proteolysis of proteins =

Synonyms

a disintegrin and metalloprotease 12, a disintegrin and metalloprotease with thrombospondin motifs 12, a disintegrin and metalloprotease-12, a disintegrin and metalloproteinase 12, a disintegrin and metalloproteinase domain 12, a disintegrin and metalloproteinase domain-containing protein 12, a disintegrin and metalloproteinase12, ADAM 12, ADAM 12-S, ADAM-12, ADAM-12m, ADAM-PCD, ADAM12, ADAM12-L, ADAM12-PC, ADAM12-S, ADAM12/meltrin alpha, ADAM12L, ADAM12S, ADAMTS-12, ADMA12L, basigin sheddase, disintegrin and metalloprotease 12, full-length ADAM 12-S, M12.212, meltrin alpha, meltrin-alpha, metalloprotease-disintegrin ADAM 12, metalloprotease-disintegrin ADAM12

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B10 ADAM12 endopeptidase

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Results	in table
8	Activating Compound
2	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
1474	Disease/ Diagnostics
13	Expression
22	General Information
1	General Stability
23	IC50 Value
63	Inhibitors
6	Ki Value [mM]
3	KM Value [mM]
16	Localization
13	Metals/Ions
27	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
64	Organism
5	pH Optimum
1	pH Range
2	pI Value
6	Posttranslational Modification
23	Protein Variants
12	Purification (Commentary)
3	Reaction
12	Reaction Type
64	Reference
138	Source Tissue
86	Substrates and Products (Substrate)
12	Subunits
141	Synonyms
7	Temperature Optimum [°C]
3	Turnover Number [1/s]

General Stability

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General Stability on EC 3.4.24.B10 - ADAM12 endopeptidase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

ADAM-12 concentration is not changed following three repeated -20°C to room temperature freeze-thaw cycles, in serum at 30°C a 10% change in concentration is observed after 14.8 hours. In serum at room temperature a 10% change in concentration is observed after 19.9 hours. In serum at refrigerator temperature a 10% change in concentration is observed after 51.0 hours. In whole blood at 30°C 64.0% is observed after 3 days. In whole blood at room temperature 81.5% is observed after 3 days. In whole blood at refrigerator temperature 96.6% is observed after 3 days.

Homo sapiens

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