3.4.24.B10: ADAM12 endopeptidase

This is an abbreviated version!
For detailed information about ADAM12 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.B10

3.4.24.B10

adams

pregnancy

trimester

integrins

metalloproteinases

myoblasts

papp-a

pregnancy-associated

preeclampsia

first-trimester

ectodomain

thrombospondin

protein-a

hb-egf

egf-like

metalloprotease-disintegrins

gestation-specific

nuchal

disintegrin-like

timp-3

adamts-7

invadopodia

medicine

metalloproteinase-12

beta-hcg

prodomain

second-trimester

igfbp-5

Reaction

proteolysis of proteins =

Synonyms

a disintegrin and metalloprotease 12, a disintegrin and metalloprotease with thrombospondin motifs 12, a disintegrin and metalloprotease-12, a disintegrin and metalloproteinase 12, a disintegrin and metalloproteinase domain 12, a disintegrin and metalloproteinase domain-containing protein 12, a disintegrin and metalloproteinase12, ADAM 12, ADAM 12-S, ADAM-12, ADAM-12m, ADAM-PCD, ADAM12, ADAM12-L, ADAM12-PC, ADAM12-S, ADAM12/meltrin alpha, ADAM12L, ADAM12S, ADAMTS-12, ADMA12L, basigin sheddase, disintegrin and metalloprotease 12, full-length ADAM 12-S, M12.212, meltrin alpha, meltrin-alpha, metalloprotease-disintegrin ADAM 12, metalloprotease-disintegrin ADAM12

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.B10 ADAM12 endopeptidase

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Results	in table
8	Activating Compound
2	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
1474	Disease/ Diagnostics
13	Expression
22	General Information
1	General Stability
23	IC50 Value
63	Inhibitors
6	Ki Value [mM]
3	KM Value [mM]
16	Localization
13	Metals/Ions
27	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
64	Organism
5	pH Optimum
1	pH Range
2	pI Value
6	Posttranslational Modification
23	Protein Variants
12	Purification (Commentary)
3	Reaction
12	Reaction Type
64	Reference
138	Source Tissue
86	Substrates and Products (Substrate)
12	Subunits
141	Synonyms
7	Temperature Optimum [°C]
3	Turnover Number [1/s]

Localization

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Localization on EC 3.4.24.B10 - ADAM12 endopeptidase

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isoform ADMA12L

additional information

Mus musculus

enzyme interacts with alpha-actinin-1 and skeletal muscle specific alpha-actinin-2 via its cytoplasmic domain, the intercation is responsible for the intracellular targeting of ADAM 12

649712