Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.24.B10: ADAM12 endopeptidase

This is an abbreviated version!
For detailed information about ADAM12 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.B10

Reaction

proteolysis of proteins =

Synonyms

a disintegrin and metalloprotease 12, a disintegrin and metalloprotease with thrombospondin motifs 12, a disintegrin and metalloprotease-12, a disintegrin and metalloproteinase 12, a disintegrin and metalloproteinase domain 12, a disintegrin and metalloproteinase domain-containing protein 12, a disintegrin and metalloproteinase12, ADAM 12, ADAM 12-S, ADAM-12, ADAM-12m, ADAM-PCD, ADAM12, ADAM12-L, ADAM12-PC, ADAM12-S, ADAM12/meltrin alpha, ADAM12L, ADAM12S, ADAMTS-12, ADMA12L, basigin sheddase, disintegrin and metalloprotease 12, full-length ADAM 12-S, M12.212, meltrin alpha, meltrin-alpha, metalloprotease-disintegrin ADAM 12, metalloprotease-disintegrin ADAM12

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B10 ADAM12 endopeptidase

Expression

Expression on EC 3.4.24.B10 - ADAM12 endopeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
5-fluorouracil induces expression of the enzyme isoform ADAM12-L but not ADAM12-S in breast cancer cells and in recurrent breast cancer tissues
a significant decrease in ADAMTS-12 mRNA levels is detected in extravillous cytotrophoblasts cultured in the presence of transforming growth factor-beta1 (1 ng/ml) for 24 - 48 h
-
ADAM12 is dynamically upregulated and under the transcriptional control of protein kinase A
ADAM12 mRNA expression is elevated 10-30fold in malignant breast tissue and metastatic lymph nodes
-
ADAM12-L mRNA expression is an independent prognostic factor in resected p-stage I lung adenocarcinoma, and is significantly correlated with tumor differentiation stage and postoperative cancer recurrence
-
ADAMTS-12 mRNA levels in extravillous cytotrophoblasts are significantly higher than those detected in JEG-3 cell. Interleukin-1beta causes a continuous and significant increase in ADAMTS-12 mRNA levels in extravillous cytotrophoblasts over time in culture
-
expression by astrocytes is increased in brain regions affected by cuprizone-induced demyelination
-
expression of ADAM12 is enriched in interleukin-17 secreting T cells
inhibition of canonical Notch signaling increases ADAM12 long isoform expression and trophoblast invasion
-
spatiotemporally expressed in decidualizing stromal cells in intact pregnant females and in pseudopregnant mice undergoing artificially induced decidualization
-
the enzyme is upregulated in human breast cancers
the enzyme is upregulated in the vessels of aggressive breast tumors
transforming growth factor beta1 is a inducer of ADAM12 mRNA and protein in fibroblasts and in mammary epithelial cells (also in human mammary epithelial cells)
-