3.4.24.B10: ADAM12 endopeptidase
This is an abbreviated version!
For detailed information about ADAM12 endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.B10
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3.4.24.B10
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adams
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pregnancy
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trimester
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integrins
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metalloproteinases
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myoblasts
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papp-a
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pregnancy-associated
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preeclampsia
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first-trimester
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ectodomain
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thrombospondin
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protein-a
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hb-egf
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egf-like
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metalloprotease-disintegrins
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gestation-specific
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nuchal
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disintegrin-like
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timp-3
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adamts-7
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invadopodia
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medicine
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metalloproteinase-12
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beta-hcg
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prodomain
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second-trimester
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igfbp-5
- 3.4.24.B10
-
adams
- pregnancy
-
trimester
- integrins
- metalloproteinases
- myoblasts
- papp-a
-
pregnancy-associated
- preeclampsia
-
first-trimester
- ectodomain
- thrombospondin
- protein-a
- hb-egf
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egf-like
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metalloprotease-disintegrins
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gestation-specific
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nuchal
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disintegrin-like
- timp-3
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adamts-7
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invadopodia
- medicine
-
metalloproteinase-12
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beta-hcg
- prodomain
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second-trimester
- igfbp-5
Reaction
proteolysis of proteins =
Synonyms
a disintegrin and metalloprotease 12, a disintegrin and metalloprotease with thrombospondin motifs 12, a disintegrin and metalloprotease-12, a disintegrin and metalloproteinase 12, a disintegrin and metalloproteinase domain 12, a disintegrin and metalloproteinase domain-containing protein 12, a disintegrin and metalloproteinase12, ADAM 12, ADAM 12-S, ADAM-12, ADAM-12m, ADAM-PCD, ADAM12, ADAM12-L, ADAM12-PC, ADAM12-S, ADAM12/meltrin alpha, ADAM12L, ADAM12S, ADAMTS-12, ADMA12L, basigin sheddase, disintegrin and metalloprotease 12, full-length ADAM 12-S, M12.212, meltrin alpha, meltrin-alpha, metalloprotease-disintegrin ADAM 12, metalloprotease-disintegrin ADAM12
ECTree
3.4.24.B10 ADAM12 endopeptidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.24.B10 - ADAM12 endopeptidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
basigin + H2O
soluble basigin fragment + ?
the enzyme binds basigin and cleaves it in the juxta membrane region, thereby releasing a soluble basigin fragment to the extracellular space
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?
pro-heparin-binding-epidermal growth factor-like growth factor + H2O
?
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?
insulin-like growth factor binding protein-3 + H2O
?
enzyme plays a role in degradation of insulin-like growth factor binding protein-3 in the blood of pregnant women
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?
insulin-like growth factor binding protein-3 + H2O
?
in serum of pregnant women
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?
protein + H2O
peptides
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key enzyme in the ectodomain shedding of membrane-anchored heparin-binding epidermal growth factor, i.e. proHB-EGF, leading to epidermal growth factor-like receptor transactivation
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?
additional information
?
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enzyme complexes alpha2-macroglobulin
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?
additional information
?
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enzyme complexes alpha2-macroglobulin
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?
additional information
?
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enzyme is a marker of skeletal muscle regeneration, binds to alpha-actinin-2 via a specific binding site, and is required for myoblast fusion
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?
additional information
?
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overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation
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?
