3.4.24.B10: ADAM12 endopeptidase

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For detailed information about ADAM12 endopeptidase, go to the full flat file.

Reaction

proteolysis of proteins =

Synonyms

a disintegrin and metalloprotease 12, a disintegrin and metalloprotease with thrombospondin motifs 12, a disintegrin and metalloprotease-12, a disintegrin and metalloproteinase 12, a disintegrin and metalloproteinase domain 12, a disintegrin and metalloproteinase domain-containing protein 12, a disintegrin and metalloproteinase12, ADAM 12, ADAM 12-S, ADAM-12, ADAM-12m, ADAM-PCD, ADAM12, ADAM12-L, ADAM12-PC, ADAM12-S, ADAM12/meltrin alpha, ADAM12L, ADAM12S, ADAMTS-12, ADMA12L, basigin sheddase, disintegrin and metalloprotease 12, full-length ADAM 12-S, M12.212, meltrin alpha, meltrin-alpha, metalloprotease-disintegrin ADAM 12, metalloprotease-disintegrin ADAM12

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B10 ADAM12 endopeptidase

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Results	in table
8	Activating Compound
2	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
1474	Disease/ Diagnostics
13	Expression
22	General Information
1	General Stability
23	IC50 Value
63	Inhibitors
6	Ki Value [mM]
3	KM Value [mM]
16	Localization
13	Metals/Ions
27	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
64	Organism
5	pH Optimum
1	pH Range
2	pI Value
6	Posttranslational Modification
23	Protein Variants
12	Purification (Commentary)
3	Reaction
12	Reaction Type
64	Reference
138	Source Tissue
86	Substrates and Products (Substrate)
12	Subunits
141	Synonyms
7	Temperature Optimum [°C]
3	Turnover Number [1/s]

Purification

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Purification on EC 3.4.24.B10 - ADAM12 endopeptidase

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

2 entries

affinity chromatography and dialysis against NaHCO3

Mus musculus

-

669346

anion exchange column chromatography and concanavalin A column chromatography

Homo sapiens

O43184

733079

DC-6xHis column affinity chromatography

Homo sapiens

-

668496

gelatin-Sepharose chromatography, cation exchange chromatography, and concanavalin A- or heparin-Sepharose affinity chromatography

Homo sapiens

-

669528

gelatin-Sepharose, cation-exchange and concanavalin A affinity chromatography

Homo sapiens

-

668501

partial, soluble recombinant protein from 293-EBNA cell and COS-1 cell medium

Homo sapiens

O43184

652002

Q-Sepharose anion exchange and gelatin-Sepharose affinity chromatography

Homo sapiens

-

669293

recombinant from COS cells

Homo sapiens

O43184

651290

recombinant protein from cell line 293-EBNA

Homo sapiens

O43184

649557

streptavidin-Sepharose chromatography and concanavalin A-Sepharose chromatography

Mus musculus

-

680219

-

Homo sapiens

-

668620

-

Homo sapiens

O43184

711148