3.4.24.B10: ADAM12 endopeptidase
This is an abbreviated version!
For detailed information about ADAM12 endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.B10
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3.4.24.B10
-
adams
-
pregnancy
-
trimester
-
integrins
-
metalloproteinases
-
myoblasts
-
papp-a
-
pregnancy-associated
-
preeclampsia
-
first-trimester
-
ectodomain
-
thrombospondin
-
protein-a
-
hb-egf
-
egf-like
-
metalloprotease-disintegrins
-
gestation-specific
-
nuchal
-
disintegrin-like
-
timp-3
-
adamts-7
-
invadopodia
-
medicine
-
metalloproteinase-12
-
beta-hcg
-
prodomain
-
second-trimester
-
igfbp-5
- 3.4.24.B10
-
adams
- pregnancy
-
trimester
- integrins
- metalloproteinases
- myoblasts
- papp-a
-
pregnancy-associated
- preeclampsia
-
first-trimester
- ectodomain
- thrombospondin
- protein-a
- hb-egf
-
egf-like
-
metalloprotease-disintegrins
-
gestation-specific
-
nuchal
-
disintegrin-like
- timp-3
-
adamts-7
-
invadopodia
- medicine
-
metalloproteinase-12
-
beta-hcg
- prodomain
-
second-trimester
- igfbp-5
Reaction
proteolysis of proteins =
Synonyms
a disintegrin and metalloprotease 12, a disintegrin and metalloprotease with thrombospondin motifs 12, a disintegrin and metalloprotease-12, a disintegrin and metalloproteinase 12, a disintegrin and metalloproteinase domain 12, a disintegrin and metalloproteinase domain-containing protein 12, a disintegrin and metalloproteinase12, ADAM 12, ADAM 12-S, ADAM-12, ADAM-12m, ADAM-PCD, ADAM12, ADAM12-L, ADAM12-PC, ADAM12-S, ADAM12/meltrin alpha, ADAM12L, ADAM12S, ADAMTS-12, ADMA12L, basigin sheddase, disintegrin and metalloprotease 12, full-length ADAM 12-S, M12.212, meltrin alpha, meltrin-alpha, metalloprotease-disintegrin ADAM 12, metalloprotease-disintegrin ADAM12
ECTree
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Reference on EC 3.4.24.B10 - ADAM12 endopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Loechel, F.; Fox, J.W.; Murphy, G.; Albrechtsen, R.; Wewer, U.M.
ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3
Biochem. Biophys. Res. Commun.
278
511-515
2000
Homo sapiens (O43184), Homo sapiens
Cao, Y.; Kang, Q.; Zolkiewska, A.
Metalloprotease-disintegrin ADAM 12 interacts with alpha-actinin-1
Biochem. J.
357
353-361
2001
Mus musculus
Loechel, F.; Wewer, U.M.
Activation of ADAM 12 protease by copper
FEBS Lett.
506
65-68
2001
Homo sapiens (O43184)
Loechel, F.; Gilpin, B.J.; Engvall, E.; Albrechtsen, R.; Wewer, U.M.
Human ADAM 12 (meltrin alpha) is an active metalloprotease
J. Biol. Chem.
273
16993-16997
1998
Homo sapiens (O43184), Homo sapiens
Loechel, F.; Overgaard, M.T.; Oxvig, C.; Albrechtsen, R.; Wewer, U.M.
Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch
J. Biol. Chem.
274
13427-13433
1999
Homo sapiens (O43184), Homo sapiens
Galliano, M.F.; Huet, C.; Frygelius, J.; Polgren, A.; Wewer, U.M.; Engvall, E.
Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha-actinin-2, is required for myoblast fusion
J. Biol. Chem.
275
13933-13939
2000
Mus musculus (Q61824)
Shi, Z.; Xu, W.; Loechel, F.; Wewer, U.M.; Murphy, L.J.
ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3
J. Biol. Chem.
275
18574-18580
2000
Homo sapiens (O43184), Homo sapiens
Eto, K.; Puzon-McLaughlin, W.; Sheppard, D.; Sehara-Fujisawa, A.; Zhang, X.P.; Takada, Y.
RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction
J. Biol. Chem.
275
34922-34930
2000
Homo sapiens
Kang, Q.; Cao, Y.; Zolkiewska, A.
Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85alpha activates phosphatidylinositol 3-kinase in C2C12 cells
J. Biol. Chem.
276
24466-24472
2001
Mus musculus
Mori, S.; Tanaka, M.; Nanba, D.; Nishiwaki, E.; Ishiguro, H.; Higashiyama, S.; Matsuura, N.
PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor
J. Biol. Chem.
278
46029-46034
2003
Homo sapiens
Cao, Y.; Zhao, Z.; Gruszczynska-Biegala, J.; Zolkiewska, A.
Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro
Mol. Cell. Biol.
23
6725-6738
2003
Mus musculus
McCulloch, D.R.; Harvey, M.; Herington, A.C.
The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone
Mol. Cell. Endocrinol.
167
11-21
2000
Homo sapiens
Kodama, T.; Ikeda, E.; Okada, A.; Ohtsuka, T.; Shimoda, M.; Shiomi, T.; Yoshida, K.; Nakada, M.; Ohuchi, E.; Okada, Y.
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor
Am. J. Pathol.
165
1743-1753
2004
Homo sapiens
Oh, M.; Im, I.; Lee, Y.J.; Kim, Y.H.; Yoon, J.H.; Park, H.G.; Higashiyama, S.; Kim, Y.C.; Park, W.J.
Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors
Bioorg. Med. Chem. Lett.
14
6071-6074
2004
Homo sapiens
Kveiborg, M.; Froehlich, C.; Albrechtsen, R.; Tischler, V.; Dietrich, N.; Holck, P.; Kronqvist, P.; Rank, F.; Mercurio, A.M.; Wewer, U.M.
A role for ADAM12 in breast tumor progression and stromal cell apoptosis
Cancer Res.
65
4754-4761
2005
Mus musculus
Masaki, M.; Kurisaki, T.; Shirakawa, K.; Sehara-Fujisawa, A.
Role of meltrin {alpha} (ADAM12) in obesity induced by high-fat diet
Endocrinology
146
1752-1763
2005
Mus musculus
Zhao, Z.; Gruszczynska-Biegala, J.; Cheuvront, T.; Yi, H.; von der Mark, H.; von der Mark, K.; Kaufman, S.J.; Zolkiewska, A.
Interaction of the disintegrin and cysteine-rich domains of ADAM12 with integrin alpha7beta1
Exp. Cell Res.
298
28-37
2004
Homo sapiens
Thodeti, C.K.; Froehlich, C.; Nielsen, C.K.; Holck, P.; Sundberg, C.; Kveiborg, M.; Mahalingam, Y.; Albrechtsen, R.; Couchman, J.R.; Wewer, U.M.
Hierarchy of ADAM12 binding to integrins in tumor cells
Exp. Cell Res.
309
438-450
2005
Homo sapiens
Thodeti, C.K.; Froehlich, C.; Nielsen, C.K.; Takada, Y.; Faessler, R.; Albrechtsen, R.; Wewer, U.M.
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins
FEBS Lett.
579
5589-5595
2005
Homo sapiens
Carl-McGrath, S.; Lendeckel, U.; Ebert, M.; Roessner, A.; Roecken, C.
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer
Int. J. Oncol.
26
17-24
2005
Homo sapiens
Roy, R.; Wewer, U.M.; Zurakowski, D.; Pories, S.E.; Moses, M.A.
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage
J. Biol. Chem.
279
51323-51330
2004
Homo sapiens
Yi, H.; Gruszczynska-Biegala, J.; Wood, D.; Zhao, Z.; Zolkiewska, A.
Cooperation of the metalloprotease, disintegrin, and cysteine-rich domains of ADAM12 during inhibition of myogenic differentiation
J. Biol. Chem.
280
23475-23483
2005
Mus musculus
Wewer, U.M.; Moergelin, M.; Holck, P.; Jacobsen, J.; Lydolph, M.C.; Johnsen, A.H.; Kveiborg, M.; Albrechtsen, R.
ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme
J. Biol. Chem.
281
9418-9422
2006
Homo sapiens
Kveiborg, M.; Albrechtsen, R.; Rudkjaer, L.; Wen, G.; Damgaard-Pedersen, K.; Wewer, U.M.
ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation
J. Bone Miner. Res.
21
1288-1296
2006
Mus musculus
Bernstein, H.G.; Keilhoff, G.; Bukowska, A.; Ziegeler, A.; Funke, S.; Dobrowolny, H.; Kanakis, D.; Bogerts, B.; Lendeckel, U.
ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes
J. Neurosci. Res.
75
353-360
2004
Homo sapiens, Rattus norvegicus
Lafuste, P.; Sonnet, C.; Chazaud, B.; Dreyfus, P.A.; Gherardi, R.K.; Wewer, U.M.; Authier, F.J.
ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation
Mol. Biol. Cell
16
861-870
2005
Homo sapiens
Peduto, L.; Reuter, V.E.; Sehara-Fujisawa, A.; Shaffer, D.R.; Scher, H.I.; Blobel, C.P.
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression
Oncogene
25
5462-5466
2006
Mus musculus
Malinin, N.L.; Wright, S.; Seubert, P.; Schenk, D.; Griswold-Prenner, I.
Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity
Proc. Natl. Acad. Sci. USA
102
3058-3063
2005
Homo sapiens
Jorgensen, L.H.; Jensen, C.H.; Wewer, U.M.; Schroder, H.D.
Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice
Am. J. Pathol.
171
1599-1607
2007
Mus musculus
Okada, A.; Mochizuki, S.; Yatabe, T.; Kimura, T.; Shiomi, T.; Fujita, Y.; Matsumoto, H.; Sehara-Fujisawa, A.; Iwamoto, Y.; Okada, Y.
ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage
Arthritis Rheum.
58
778-789
2008
Homo sapiens
Jacobsen, J.; Visse, R.; Sorensen, H.P.; Enghild, J.J.; Brew, K.; Wewer, U.M.; Nagase, H.
Catalytic properties of ADAM12 and its domain deletion mutants
Biochemistry
47
537-547
2008
Homo sapiens
Froehlich, C.; Albrechtsen, R.; Dyrskjot, L.; Rudkjaer, L.; Orntoft, T.F.; Wewer, U.M.
Molecular profiling of ADAM12 in human bladder cancer
Clin. Cancer Res.
12
7359-7368
2006
Homo sapiens (O43184), Homo sapiens
Kveiborg, M.; Albrechtsen, R.; Couchman, J.R.; Wewer, U.M.
Cellular roles of ADAM12 in health and disease
Int. J. Biochem. Cell Biol.
40
1685-1702
2008
Homo sapiens, Mus musculus
Dyczynska, E.; Syta, E.; Sun, D.; Zolkiewska, A.
Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein
Int. J. Cancer
122
2634-2640
2008
Mus musculus
Atfi, A.; Dumont, E.; Colland, F.; Bonnier, D.; Lhelgoualch, A.; Prunier, C.; Ferrand, N.; Clement, B.; Wewer, U.M.; Theret, N.
The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor
J. Cell Biol.
178
201-208
2007
Homo sapiens
Estrella, C.; Rocks, N.; Paulissen, G.; Quesada-Calvo, F.; Noel, A.; Vilain, E.; Lassalle, P.; Tillie-Leblond, I.; Cataldo, D.; Gosset, P.
Role of a disintegrin and metalloprotease-12 in neutrophil recruitment induced by airway epithelium
Am. J. Respir. Cell Mol. Biol.
41
449-458
2009
Homo sapiens
Kveiborg, M.; Jacobsen, J.; Lee, M.H.; Nagase, H.; Wewer, U.M.; Murphy, G.
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)
Biochem. J.
430
79-86
2010
Homo sapiens (O43184)
Baertling, F.; Kokozidou, M.; Pufe, T.; Clarner, T.; Windoffer, R.; Wruck, C.J.; Brandenburg, L.O.; Beyer, C.; Kipp, M.
ADAM12 is expressed by astrocytes during experimental demyelination
Brain Res.
1326
1-14
2010
Mus musculus
Zhang, L.; Guo, W.; Chen, Q.; Fan, X.; Zhang, Y.; Duan, E.
Adam12 plays a role during uterine decidualization in mice
Cell Tissue Res.
338
413-421
2009
Mus musculus
Oh, S.T.; Cho, B.K.; Schramme, A.; Gutwein, P.; Tilgen, W.; Reichrath, J.
Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ
Dermato-endocrinology
1
46-53
2009
Homo sapiens
Stautz, D.; Sanjay, A.; Hansen, M.T.; Albrechtsen, R.; Wewer, U.M.; Kveiborg, M.
ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity
Exp. Cell Res.
316
55-67
2010
Homo sapiens
Solomon, E.; Li, H.; Muggy, S.D.; Syta, E.; Zolkiewska, A.
The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12
J. Biol. Chem.
285
21969-21977
2010
Mus musculus
Mino, N.; Miyahara, R.; Nakayama, E.; Takahashi, T.; Takahashi, A.; Iwakiri, S.; Sonobe, M.; Okubo, K.; Hirata, T.; Sehara, A.; Date, H.
A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma
J. Surg. Oncol.
100
267-272
2009
Homo sapiens
Kerna, I.; Kisand, K.; Tamm, A.E.; Lintrop, M.; Veske, K.; Tamm, A.O.
Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort
Osteoarthritis Cartilage
17
1093-1098
2009
Homo sapiens (O43184), Homo sapiens
Cowans, N.J.; Stamatopoulou, A.; Jaakohuhta, S.; Spencer, K.
ADAM-12 stability in first trimester maternal serum
Prenat. Diagn.
30
555-560
2010
Homo sapiens
Lin, J.; Luo, J.; Redies, C.
Molecular characterization and expression analysis of ADAM12 during chicken embryonic development
Dev. Growth Differ.
52
757-769
2010
Gallus gallus
Roy, R.; Rodig, S.; Bielenberg, D.; Zurakowski, D.; Moses, M.A.
ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis
J. Biol. Chem.
286
20758-20768
2011
Homo sapiens
Beristain, A.; Zhu, H.; Leung, P.
Regulated expression of ADAMTS-12 in human trophoblastic cells: A role for ADAMTS-12 in epithelial cell invasion?
PLoS ONE
6
e18473
2011
Homo sapiens
Kotzsch, A.; Skovgaard, T.; Buus, U.; Andersen, S.; Devkota, K.; Berthelsen, J.
A substrate-optimized electrophoretic mobility shift assay for ADAM12
Anal. Biochem.
452
34-42
2014
Homo sapiens (O43184)
Aghababaei, M.; Hogg, K.; Perdu, S.; Robinson, W.P.; Beristain, A.G.
ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion
Cell Death Differ.
22
1970-1984
2015
Homo sapiens (O43184)
Wei, J.; Richbourgh, B.; Jia, T.; Liu, C.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation
Mediators Inflamm.
2014
649718
2014
Homo sapiens (O43184)
Leyme, A.; Bourd-Boittin, K.; Bonnier, D.; Falconer, A.; Arlot-Bonnemains, Y.; Theret, N.
Identification of ILK as a new partner of the ADAM12 disintegrin and metalloprotease in cell adhesion and survival
Mol. Biol. Cell
23
3461-3472
2012
Homo sapiens (O43184), Homo sapiens
Ieguchi, K.; Tomita, T.; Omori, T.; Komatsu, A.; Deguchi, A.; Masuda, J.; Duffy, S.L.; Coulthard, M.G.; Boyd, A.; Maru, Y.
ADAM12-cleaved ephrin-A1 contributes to lung metastasis
Oncogene
33
2179-2190
2014
Mus musculus
Aghababaei, M.; Beristain, A.
The Elsevier trophoblast research award lecture: Importance of metzincin proteases in trophoblast biology and placental development: A focus on ADAM12
Placenta
36
S11-S19
2015
Mus musculus
-
Stautz, D.; Wewer, U.M.; Kveiborg, M.
Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12
PLoS ONE
7
e37628
2012
Homo sapiens (O43184)
Zhou, A.X.; El Hed, A.; Mercer, F.; Kozhaya, L.; Unutmaz, D.
The metalloprotease ADAM12 regulates the effector function of human Th17 cells
PLoS ONE
8
e81146
2013
Homo sapiens (O43184), Homo sapiens
Albrechtsen, R.; Wewer Albrechtsen, N.J.; Gnosa, S.; Schwarz, J.; Dyrskjot, L.; Kveiborg, M.
Identification of ADAM12 as a novel basigin sheddase
Int. J. Mol. Sci.
20
E1957
2019
Homo sapiens (O43184), Homo sapiens
Duhachek-Muggy, S.; Qi, Y.; Wise, R.; Alyahya, L.; Li, H.; Hodge, J.; Zolkiewska, A.
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer
Mol. Cancer
16
32
2017
Homo sapiens (O43184), Homo sapiens
Roy, R.; Dagher, A.; Butterfield, C.; Moses, M.A.
ADAM12 is a novel regulator of tumor angiogenesis via STAT3 signaling
Mol. Cancer Res.
15
1608-1622
2017
Homo sapiens (O43184), Homo sapiens
Aghababaei, M.; Beristain, A.G.
The Elsevier Trophoblast Research Award Lecture Importance of metzincin proteases in trophoblast biology and placental development a focus on ADAM12
Placenta
36 Suppl 1
S11-S19
2015
Mus musculus
Cui, D.; Arima, M.; Takubo, K.; Kimura, T.; Horiuchi, K.; Minagawa, T.; Matsuda, S.; Ikeda, E.
ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function
Sci. Rep.
5
12796
2015
Mus musculus (Q61824)
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