3.4.24.B10: ADAM12 endopeptidase

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For detailed information about ADAM12 endopeptidase, go to the full flat file.

Reaction

proteolysis of proteins =

Synonyms

a disintegrin and metalloprotease 12, a disintegrin and metalloprotease with thrombospondin motifs 12, a disintegrin and metalloprotease-12, a disintegrin and metalloproteinase 12, a disintegrin and metalloproteinase domain 12, a disintegrin and metalloproteinase domain-containing protein 12, a disintegrin and metalloproteinase12, ADAM 12, ADAM 12-S, ADAM-12, ADAM-12m, ADAM-PCD, ADAM12, ADAM12-L, ADAM12-PC, ADAM12-S, ADAM12/meltrin alpha, ADAM12L, ADAM12S, ADAMTS-12, ADMA12L, basigin sheddase, disintegrin and metalloprotease 12, full-length ADAM 12-S, M12.212, meltrin alpha, meltrin-alpha, metalloprotease-disintegrin ADAM 12, metalloprotease-disintegrin ADAM12

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B10 ADAM12 endopeptidase

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Results	in table
8	Activating Compound
2	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
1474	Disease/ Diagnostics
13	Expression
22	General Information
1	General Stability
23	IC50 Value
63	Inhibitors
6	Ki Value [mM]
3	KM Value [mM]
16	Localization
13	Metals/Ions
27	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
64	Organism
5	pH Optimum
1	pH Range
2	pI Value
6	Posttranslational Modification
23	Protein Variants
12	Purification (Commentary)
3	Reaction
12	Reaction Type
64	Reference
138	Source Tissue
86	Substrates and Products (Substrate)
12	Subunits
141	Synonyms
7	Temperature Optimum [°C]
3	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 3.4.24.B10 - ADAM12 endopeptidase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

glycoprotein

Homo sapiens

O43184

degylcosylation with endoglycosidase H

651920

phosphoprotein

Homo sapiens

-

c-Src kinase activity regulates ADAM12-L phosphorylation (tyrosine phosphorylation) and the c-Src-ADAM12-L interaction, the cytoplasmic tail of ADAM12-L has two Src SH3-binding sites, the high-affinity c-Src binding site is important for its cellular localization with c-Src to actin-rich structures at the cell periphery

711938

proteolytic modification

4 entries

proteolytic modification

Homo sapiens

O43184

autocleavage occurs near the junction of the prodomain and the catalytic domain upon inactivation of cysteine residues C179 and in presence of Cu2+ which is further promoted in presence of ascorbate, multistep activation mechanism involving both furin cleavage and copper binding

651290

proteolytic modification

Homo sapiens

O43184

the cysteine-switch of the prodomain maintaines the zymogen in a latent state, enzyme is synthesized as a catalytically inactive zymogen, in vivo cleavage by a furin-like endopeptidase, activation is chemically possible with N-ethylmaleimide, but not with Hg2+

651886

proteolytic modification

Homo sapiens

O43184

the cysteine-switch of the prodomain maintaines the zymogen in a latent state, enzyme is synthesized as a catalytically inactive zymogen, in vivo cleavage by a furin-like endopeptidase, autoactivation is possible with N-ethylmaleimide

651920

proteolytic modification

Mus musculus

-

-

653221