Literature summary for 3.4.24.B10 extracted from

Okada, A.; Mochizuki, S.; Yatabe, T.; Kimura, T.; Shiomi, T.; Fujita, Y.; Matsumoto, H.; Sehara-Fujisawa, A.; Iwamoto, Y.; Okada, Y.
ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage (2008), Arthritis Rheum., 58, 778-789.

Search for more literature for 3.4.24.B10

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	no changes in expression after stimulation with tumor necrosis factor alpha, interleukin-1alpha, basic fibroblast growth factor, heparin-binding epidermal growth factor, insulin-like growth factor-1, or vascular endothelial growth factor 165	Homo sapiens
transforming growth factor beta	ADAM-12m expression in osteoarthritic chondrocytes is selectively enhanced by transforming growth factor beta	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Aprotinin	0.1 mg/ml	Homo sapiens
BB94	0.01 mM	Homo sapiens
KB-R7785	0.001 mM	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cartilage	osteoarthritic cartilage	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
insulin-like growth factor binding protein 5 + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ADAM-12	-	Homo sapiens
ADAM-12m	prototype membrane-anchored ADAM-12	Homo sapiens
meltrin alpha	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)