Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.B10 extracted from

  • Kang, Q.; Cao, Y.; Zolkiewska, A.
    Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85alpha activates phosphatidylinositol 3-kinase in C2C12 cells (2001), J. Biol. Chem., 276, 24466-24472.
    View publication on PubMed
Search for more literature for 3.4.24.B10

Cloned(Commentary)

Cloned (Comment) Organism
expression as GFP-pleckstrin homology domain fusion protein in C2C12 cells, targeted to the plasma membrane by a myristoylation motif Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of deletion mutants Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloprotease Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Mus musculus
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle gene expression Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme provides docking sites for the Src homology 3 domain of p85alpha and thus activates PI 3-kinase by mediating its recruitment to the membrane Mus musculus ?
-
 ?
protein + H2O
-
 Mus musculus peptides
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloprotease-12
-
 Mus musculus
ADAM 12
-
 Mus musculus
M12.212 Merops-ID Mus musculus